scholarly journals Ranges of protons in biological targets

2017 ◽  
Vol 68 (4) ◽  
pp. 306-311
Author(s):  
Márius Pavlovič ◽  
Andreas Hammerle

AbstractThe paper introduces a simple fitting function for quick assessment of proton ranges in biological targets and human tissues. The function has been found by fitting an extensive data set of Monte Carlo proton ranges obtained with the aid of the SRIM-2013 code. The data has been collected for 28 different targets at 8 energies in the interval from 60 MeV to 220 MeV. The paper shows that at a given kinetic proton-beam energy, the Monte Carlo ranges can be satisfactorily fitted by a power function that depends solely on the target density. This is a great advantage for targets, for which the exact chemical composition is not known, or the mean ionizing potential is not reliably known. The satisfactory fit is meant as the fit that stays within the natural range straggling of the Monte Carlo ranges. In the second step, the energy-scaling yielding a universal fitting formula for proton ranges as a function of proton-beam energy and target density is introduced and discussed.

2021 ◽  
Vol 11 (22) ◽  
pp. 10856
Author(s):  
Ngoc Han Huynh ◽  
James C. L. Chow

Heavy atom nanoparticles, such as gold nanoparticles, are proven effective radiosensitizers in radiotherapy to enhance the dose delivery for cancer treatment. This study investigated the effectiveness of cancer cell killing, involving gold nanoparticle in proton radiation, by changing the nanoparticle size, proton beam energy, and distance between the nanoparticle and DNA. Monte Carlo (MC) simulation (Geant4-DNA code) was used to determine the dose enhancement in terms of dose enhancement ratio (DER), when a gold nanoparticle is present with the DNA. With varying nanoparticle size (radius = 15–50 nm), distance between the gold nanoparticle and DNA (30–130 nm), as well as proton beam energy (0.5–25 MeV) based on the simulation model, our results showed that the DER value increases with a decrease of distance between the gold nanoparticle and DNA and a decrease of proton beam energy. The maximum DER (1.83) is achieved with a 25 nm-radius gold nanoparticle, irradiated by a 0.5 MeV proton beam and 30 nm away from the DNA.


2013 ◽  
Vol 76 (12) ◽  
pp. 1490-1496
Author(s):  
A. N. Zelenski ◽  
G. Atoian ◽  
A. A. Bogdanov ◽  
S. B. Nurushev ◽  
F. S. Pylaev ◽  
...  

Author(s):  
Tara Mastren ◽  
Christiaan Vermeulen ◽  
Mark Brugh ◽  
Eva R. Birnbaum ◽  
Meiring F. Nortier ◽  
...  

Author(s):  
Chaoyue Zhang ◽  
Xiaohua Liang ◽  
Yanbing Xu ◽  
Wenxi Peng ◽  
Jianjian He ◽  
...  

1997 ◽  
Author(s):  
D. L. Bleuel ◽  
R. J. Donahue ◽  
B. A. Ludewigt

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