Cutaneous Lymphocyte Antigen (CLA)

2016 ◽  
Author(s):  
Douglas M. Templeton ◽  
Michael Schwenk ◽  
Reinhild Klein ◽  
John H. Duffus
Keyword(s):  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

Primary Cutaneous ALCL With Phosphorylated/Activated Cytoplasmic ALK and Novel Phenotype: EMA/MUC1+, Cutaneous Lymphocyte Antigen Negative

2008 ◽  
Vol 32 (9) ◽  
pp. 1421-1426 ◽  
Author(s):  
Marshall E. Kadin ◽  
Jack L. Pinkus ◽  
Geraldine S. Pinkus ◽  
Ivan H. Duran ◽  
Christine E. Fuller ◽  
...  
Keyword(s):  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

Targeting the cutaneous lymphocyte antigen (CLA) in inflammatory and neoplastic skin conditions

2020 ◽  
Vol 20 (3) ◽  
pp. 275-282 ◽  
Author(s):  
Alvise Sernicola ◽  
Irene Russo ◽  
Micol Silic-Benussi ◽  
Vincenzo Ciminale ◽  
Mauro Alaibac
Keyword(s):  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen ◽  
Skin Conditions

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis

2006 ◽  
Vol 117 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Janine Bilsborough ◽  
Donald Y.M. Leung ◽  
Mark Maurer ◽  
Michael Howell ◽  
Mark Boguniewcz ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Positive Skin ◽  
Lymphocyte Antigen ◽  
Skin Homing ◽  
Cutaneous Lymphocyte Antigen

Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis

1996 ◽  
Vol 39 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Costantino Pitzalis ◽  
Alberto Cauli ◽  
Nicolo Pipitone ◽  
Catherine Smith ◽  
Jonathan Barker ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
T Lymphocytes ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

Neutrophils, Monocytes, and Dendritic Cells Express the Same Specialized Form of PSGL-1 as Do Skin-Homing Memory T Cells: Cutaneous Lymphocyte Antigen

2001 ◽  
Vol 285 (3) ◽  
pp. 577-587 ◽  
Author(s):  
J.David Kieffer ◽  
Robert C. Fuhlbrigge ◽  
Dieter Armerding ◽  
Caroline Robert ◽  
Katalin Ferenczi ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Memory T Cells ◽  
Lymphocyte Antigen ◽  
Skin Homing ◽  
Specialized Form ◽  
Cutaneous Lymphocyte Antigen

scholarly journals Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 ◽  
Vol 127 (5) ◽  
pp. 1485-1495 ◽  
Author(s):  
R Alon ◽  
H Rossiter ◽  
X Wang ◽  
T A Springer ◽  
T S Kupper
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
Cell Surface ◽  
Antigen Expression ◽  
Lymphocyte Antigen ◽  
Selectin Ligands ◽  
Distinct Cell ◽  
Cutaneous Lymphocyte Antigen

Memory T lymphocytes extravasate at sites of inflammation, but the mechanisms employed by these cells to initiate contact and tethering with endothelium are incompletely understood. An important part of leukocyte extravasation is the initiation of rolling adhesions on endothelial selectins; such events have been studied in monocytes and neutrophils but not lymphocytes. In this study, the potential of T lymphocytes to adhere and roll on endothelial selectins in vitro was investigated. We demonstrate that T cells can form tethers and rolling adhesions on P selectin and E selectin under physiologic flow conditions. Tethering and rolling on P selectin was independent of cell-surface cutaneous lymphocyte antigen (CLA) expression, which correlated strictly with the capacity of T cells to form rolling adhesions under flow on E selectin. T cell tethering to P selectin was abolished by selective removal of cell surface sialomucins by a P. haemolytica O-glycoprotease, while cutaneous lymphocyte antigen expression was unaffected. A sialomucin molecule identical or closely related to P selectin glycoprotein ligand-1 (PSGL-1), the major P selectin ligand on neutrophils and HL-60 cells, appears to be a major T cell ligand for P selectin. P selectin glycoprotein ligand-1 does not appear to support T cell rolling on E selectin. In turn, E selectin ligands do not appear to be associated with sialomucins. These data demonstrate the presence of structurally distinct ligands for P or E selectins on T cells, provide evidence that both ligands can be coexpressed on a single T cell, and mediate tethering and rolling on the respective selectins in a mutually exclusive fashion.

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