A new phenolic glucoside and flavonoids from the bark of Eucommia ulmoides Oliv.

Holzforschung ◽  
2010 ◽  
Vol 64 (5) ◽  
Author(s):  
Li-Na Yao ◽  
Yan-Fang Su ◽  
Zhao-Ye Yin ◽  
Nan Qin ◽  
Tian-Xiang Li ◽  
...  
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Eucommia Ulmoides ◽  
Oroxylin A ◽  
Phytochemical Investigation ◽  
Phenolic Glucoside ◽  
First Time

Abstract Phytochemical investigation of Eucommia ulmoides bark led to the isolation of a new phenolic glucoside which was named eucophenoside. The structure of eucophenoside was elucidated by extensive spectroscopic data analysis. In addition, seven known flavonoids were reported for the first time to be present in the bark of E. ulmoides: wogonin, oroxylin A, baicalein, 4,2′,4′-trihydroxychalcone, (αR)-α,4,2′,4′-tetrahydroxydihydrochalcone, (αR)-α-O-β-d-glucopyranosyl-4,2′,4′-trihydroxydihydrochalcone, and wogonoside.

scholarly journals Constituents of the Leaves of Verbascum blattaria

2015 ◽  
Vol 10 (3) ◽  
pp. 1934578X1501000
Author(s):  
I-Soo Youn ◽  
Ah-Reum Han ◽  
Mark S. Roh ◽  
Eun-Kyoung Seo
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Isolation And Identification ◽  
Phytochemical Investigation ◽  
First Time ◽  
Ethylhexyl Phthalate

Phytochemical investigation of the dried leaves of Verbascum blattaria L. (Scrophulariaceae) led to the isolation and identification of five known compounds, E-harpagoside, laterioside, kaempferol 3- O-β-D-glucopyranoside, bis(2-ethylhexyl)phthalate, and (2 S)-liquiritigenin. The structures of these compounds were determined by physical and spectroscopic data analysis. All compounds were isolated from V. blattaria for the first time.

scholarly journals Saccharpiscinols A–C: Flavans with Potential Inflammatory Activities from One Actinobacteria Saccharomonospora piscinae

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4909
Author(s):  
Yung-Shun Su ◽  
Jih-Jung Chen ◽  
Ming-Jen Cheng ◽  
Chee-Yin Chai ◽  
Aij-Lie Kwan ◽  
...  
Keyword(s):  
Data Analysis ◽  
Chromatographic Separation ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
No Production ◽  
Raw 264.7 ◽  
Phytochemical Investigation ◽  
Inhibitory Activities ◽  
New Compounds ◽  
First Time

Phytochemical investigation and chromatographic separation of extracts from the actinobacteria strain Saccharomonospora piscinae that was isolated from dried fishpond sediment of Kouhu township, in the south of Taiwan, led to the isolation of three new compounds, saccharpiscinols A–C (1–3, respectively), and three new natural products, namely (2S)-5,7,3′,4′-tetrahydroxy-6,8-dimethylflavanone (4), methyl-4-hydroxy-2-methoxy-6-methylbenzoate (5), and (±)-7-acetyl-4,8-dihydroxy-6-methyl-1-tetralone (6). Compounds 4–6 were reported before as synthesized products, herein, they are reported from nature for the first time. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. The effect of some isolates on the inhibition of NO production in lipopolysaccharide-activated RAW 264.7 murine macrophages was evaluated. Saccharpiscinol A showed inhibitory activities against LPS-induced NO production.

scholarly journals Bioassay-Guided Isolation of Triterpenoids as α-Glucosidase Inhibitors from Cirsium setosum

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1844
Author(s):  
Xiuting Li ◽  
Xiangjian Zhong ◽  
Xin Wang ◽  
Jinjie Li ◽  
Jiachen Liu ◽  
...  
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Ethanol Extract ◽  
Positive Control ◽  
Inhibition Activity ◽  
Bioactive Components ◽  
Chemical Structures ◽  
Glucosidase Inhibitors ◽  
Ic50 Values ◽  
First Time

Cirsium setosum (C. setosum) has a potential antihyperglycemic effect, but it is unclear what bioactive components play a key role. According to the α-glucosidase inhibition activity, three new taraxastane-type triterpenoids of 3β-hydroxy-30-hydroperoxy-20-taraxastene (1), 3β-hydroxy-22α-methoxy-20-taraxastene (2), and 30-nor-3β,22α-dihydroxy-20-taraxastene (3), as well as five known taraxastane triterpenoids of 3β,22-dihydroxy-20-taraxastene (4), 20-taraxastene-3,22-dione (5), 3β-acetoxy-20-taraxasten-22-one (6), 3β-hydroxy-20-taraxasten-22-one (7), and 30-nor-3β-hydroxy-20-taraxastene (8) were obtained from the petroleum ether-soluble portion of the ethanol extract from C. setosum. All chemical structures of the compounds were elucidated by spectroscopic data analysis and compared with literature data. Compounds 4–8 were identified for the first time from this plant, and compounds 1, 2, 4, and 7 exhibited more potent α-glucosidase inhibitory activity—with IC50 values of 18.34 ± 1.27, 26.98 ± 0.89, 17.49 ± 1.42, and 22.67 ± 0.25 μM, respectively—than acarbose did (positive control, IC50 42.52 ± 0.32 μM).

Bioactivity-guided isolation of aurone derivatives with hepatoprotective activities from the fruits of Cucumis bisexualis

2020 ◽  
Vol 75 (9-10) ◽  
pp. 327-332 ◽  
Author(s):  
Qin-Ge Ma ◽  
Rong-Rui Wei ◽  
Zhi-Pei Sang
Keyword(s):  
Spectroscopic Data ◽  
Positive Control ◽  
Phytochemical Investigation ◽  
First Time

AbstractBioactivity-guided phytochemical investigation of Cucumis bisexualis has led to the isolation of three new coumarin-aurone heterodimers (1-3), along with six aurone derivatives (4-9) were isolated from C. bisexualis for the first time. Their structures were determined by their extensive spectroscopic data and comparison with the values reported in the references. All isolated compounds (1-9) were evaluated for their hepatoprotective activities on human L-O2 cells, which compared with positive control of Bifendatatum. Among them, compounds 1, 2, and 7 exhibited moderate hepatoprotective activities to promote effects on the proliferation of L-O2 cells.

scholarly journals FLAVONOIDS ISOLATED FROM THE FLOWERS OF CAMELLIA CHRYSANTHA

2019 ◽  
Vol 57 (3) ◽  
pp. 287
Author(s):  
Hong Van Thi Nguyen ◽  
Bach Cao Pham ◽  
Inh Thi Cam ◽  
Phuong Lan Doan ◽  
Thanh Tat Le ◽  
...  
Keyword(s):  
Data Analysis ◽  
Methyl Ether ◽  
Spectroscopic Data ◽  
Chemical Constituents ◽  
Health Benefits ◽  
Small Tree ◽  
Evergreen Shrub ◽  
Chemical Structures ◽  
The Family ◽  
First Time

Camellia chrysantha (the golden camellia, golden tea) is a species of evergreen shrub or small tree belonging to the family Theaceae. The flowers and the leaves of this plant are used as tea and drank for its health benefits. The aim of this study was to investigate the chemical constituents of the flowers of Camellia chrysantha. Five flavonoids were isolated from the flowers of Camellia chrysantha (Theaceae), including (+)-catechin (1), (-)-epicatechin (2), quercetin (3), quercetin-3-O-methyl ether (4) and kaempferol (5). Their chemical structures were elucidated by spectroscopic data analysis and by comparison with those reported in the literature. Among five compounds, compounds 4 was isolated for the first time from this species.

scholarly journals Structural Characterization and Hepatoprotective Activity of Naphthoquinone From Cucumis bisexualis

2020 ◽  
Vol 15 (1) ◽  
pp. 1934578X2090289 ◽  
Author(s):  
Qinge Ma ◽  
Rongrui Wei ◽  
Zhipei Sang
Keyword(s):  
Data Analysis ◽  
Structural Characterization ◽  
Spectroscopic Data ◽  
Furan Ring ◽  
Hepatoprotective Activity ◽  
First Time ◽  
Chemical Evidence

Three new naphthoquinones, namely 5,8-dihydroxy-7′-isopropyl-furan ring-1″-prenyl-naphthoquinone (1), 5,8-dihydroxy-7′-propenyl-furan ring-1″-isopropanol-naphthoquinone (2), and 5,8-dihydroxy-7′-isopropanol-furan ring-1″-(5″-hydroxyphenyl)-naphthoquinone (3), along with 10 known naphthoquinone derivatives (4-13) were isolated from Cucumis bisexualis for the first time. All the compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Compounds (1-13) were evaluated for their hepatoprotective activites on human L-O2 cells. Among them, compounds 1, 4, and 8 exhibited significant promotion effects on the proliferation of L-O2 cells.

scholarly journals Lignans and Terpenoids From the Fruits of Vitex kwangsiensia and Their Inhibitory Activity on Nitric Oxide Production in Macrophages

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984817
Author(s):  
Tong Shen ◽  
Yongdong Wang ◽  
Zhiming Zhu ◽  
Xiujie Wang ◽  
Tian Tian
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Spectroscopic Methods ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Raw264.7 Macrophages ◽  
Phytochemical Investigation ◽  
Reported Data ◽  
First Time

Phytochemical investigation of the fruits from Vitex kwangsiensia led to the isolation of 18 constituents, including 6 lignans (1-6), 3 diterpenoids (7-9), 2 sesquiterpenoids (10, 11), 2 triterpenoids (16, 17), and 5 other compounds. Their structures were identified by spectroscopic methods (mass spectroscopy, infrared, UV, 1-dimensional and 2-dimensional nuclear magnetic resonance) and comparison with reported data in the literatures. Among these constituents, compound 1 was a new lignan and named as vitekwangin A. The spectroscopic data of 2 was reported herein for the first time, and given a trivial name vitekwangin B. The isolated lignans, diterpenoids, and sesquiterpenoids were evaluated for their inhibitory activity to prevent nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophages.

scholarly journals A New Ajmaline-type Alkaloid from the Roots of Rauvolfia serpentina

2017 ◽  
Vol 12 (4) ◽  
pp. 1934578X1701200
Author(s):  
Thitima Rukachaisirikul ◽  
Suwadee Chokchaisiri ◽  
Parichat Suebsakwong ◽  
Apichart Suksamrarn ◽  
Chainarong Tocharus
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Anticholinesterase Activity ◽  
Rauvolfia Serpentina ◽  
Vasorelaxant Activity ◽  
First Time

A new ajmaline-type alkaloid, 21- O-methylisoajmaline (1), together with twenty-one known compounds, a mixture ofβ-sitosterol (2) and stigmasterol (3), reserpinine (4), tetrahydroalstonine (5), reserpine (6), venoterpine (7), yohimbine (8), 6'- O-(3,4,5-trimethoxybenzoyl)glomeratose A (9), isoajmaline (10), 3- epi-α-yohimbine (11), methyl 3,4,5-trimethoxy- trans-cinnamate (12), a mixture of β-sitosterol 3- O-β-D-glucopyranoside (13) and stigmasterol 3- O-β-D-glucopyranoside (14), rescidine (15), 7-deoxyloganic acid (16), ajmaline (17), suaveoline (18), (+)-tetraphyllicine (19), loganic acid (20), 3-hydroxysarpagine (21), and sarpagine (22), were isolated from the roots of Rauvolfia serpentina. Their structures were elucidated by spectroscopic data analysis and comparison with literature data. Compounds 11, 12 and 15 were for the first time identified from the genus Rauvolfia and 5, 7, 11, 12, 15, 18 and 22 were found from R. serpentina for the first time. Compound 11 showed moderate anticholinesterase activity with IC50 value of 15.58 μM, whereas 6 exhibited strong vasorelaxant activity with the EC50 value of 0.05 μM.

scholarly journals New polyoxygenated polyketide from pathogenic fungus Cylindrocarpon destructans with α-glycosidase inhibitory activity

2018 ◽  
Vol 7 (4) ◽  
pp. 303-307
Author(s):  
Dilfaraz Khan ◽  
Shahid Ullah Khan ◽  
Shah Iram Niaz ◽  
Muhammad Haroon ◽  
Syed Badshah ◽  
...  
Keyword(s):  
Data Analysis ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Pathogenic Fungus ◽  
2D Nmr ◽  
Inhibition Activity ◽  
Cylindrocarpon Destructans ◽  
Phytochemical Investigation ◽  
Glycosidase Inhibition

Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of one new polyoxygenated polyketides, namely cylindrocarpolide A along with five known compounds. The structures of the isolated compounds were elucidated by 1D and 2D NMR and mass spectroscopic data analysis. The isolated compounds were evaluated for α-glycosidase inhibition activity. The compounds isolated compounds were found to have strong to weak inhibition against the α-glycosidase enzymes

scholarly journals Chemical Constituents From the Bark of Garcinia oblongifolia

2020 ◽  
Vol 15 (8) ◽  
pp. 1934578X2094466
Author(s):  
Yutong Han ◽  
Xingyu Li ◽  
Chaonan Yuan ◽  
Ronghui Gu ◽  
Edward J. Kennelly ◽  
...  
Keyword(s):  
Data Analysis ◽  
Spectroscopic Data ◽  
Protocatechuic Acid ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Phytochemical Investigation

The phytochemical investigation of the methanol extract of bark of Garcinia oblongifolia yielded a new xanthone derivative 1,3,8-trihydroxy-6’,6’-dimethylpyrano (2’,3’:5,6) xanthone (5) along with 8 known compounds, including 1,2,5-trihydroxy-6-methoxyxanthone (1), 1,3,6,7-tetrahydroxy-2,5-bis (3-methylbut-2-enyl) xanthen-9-one (2), xanthone V1 (3), isojacareubin (4), methyl protocatechuate (6), isoxanthochymol (7), euxanthone (8), and protocatechuic acid (9). The structures of these compounds were verified based on extensive spectroscopic data analysis as well as comparison with the literature data.

Sign in / Sign up

Export Citation Format

Share Document