Hydrogels from chitosan crosslinked with poly(ethylene glycol) diacid as bone regeneration materials

e-Polymers ◽  
2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Rosica Mincheva ◽  
Nevena Manolova ◽  
Rumen Sabov ◽  
Galen Kjurkchiev ◽  
Iliya Rashkov
Keyword(s):  
Ethylene Glycol ◽  
Bone Regeneration ◽  
Heating Temperature ◽  
Polymer Networks ◽  
Crosslinking Agent ◽  
Poly Ethylene Glycol ◽  
Simple Method ◽  
Equilibrium Degree ◽  
Poly Ethylene

Abstract A simple method to covalently crosslink chitosan using poly(ethylene glycol) diacid as crosslinking agent is proposed. Networks net-chitosan-ι- PEG(COOH)2 were obtained by heating chitosan in aqueous PEG600(COOH)2 solutions at a temperature higher than 60°C. IR spectroscopy revealed the formation of amide bonds. It is shown that the obtained chemical networks are pH-sensitive hydrogels with enhanced hydrophilicity. The equilibrium degree of swelling of the hydrogels is determined by the conditions of their preparation - heating temperature and mole ratio between chitosan and the crosslinker. The ability of the polymer networks to facilitate bone regeneration processes was shown by in vivo implantation experiments.

scholarly journals Semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol)

2008 ◽  
Vol 62 (6) ◽  
pp. 345-351 ◽  
Author(s):  
Nedeljko Milosavljevic ◽  
Melina Kalagasidis-Krusic ◽  
Jovanka Filipovic
Keyword(s):  
Mechanical Properties ◽  
Ethylene Glycol ◽  
Pore Size ◽  
Biomedical Application ◽  
Polymer Networks ◽  
Crosslinking Agent ◽  
Interpenetrating Polymer Networks ◽  
Swelling Kinetics ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Chitosan is a natural polycationic polymer that possesses useful properties such as bioactivity, biocompatibility, non-toxicity and non-antigenicity. On the other hand, its mechanical properties are not good for some biomedical application. They may be improved by preparing semi-interpenetrating polymer networks (semi-IPNs), when the hydrogel network is prepared in the presence of a previously made polymer such as poly(ethylene glycol). This paper deals with synthesis and characterization of the semi-interpenetrating polymer networks of chitosan and poly(ethylene glycol) with different Ch/PEG ratio and crosslinking degree. The degree of deacetylation of chitosan was determined by potentiometric titration, titration and elemental analysis. The semi-IPNs were characterized by swelling kinetics, mechanical properties and thermal analysis. It was found that PEG content and crosslinking agent concentration significantly influence the swelling behaviour of semi-IPNs. Water uptake was higher for lower crosslinking agent concentrations and PEG contents, up to PEG/Ch = 0,75. Better mechanical strength of semi-IPNs was obtained for higher PEG content and crosslinking agent concentration. SEM analysis confirmed the porous structure of semi-IPNs. Increasing the degree of crosslinking and PEG content up to PEG/Ch = 0,75, the pore size decreased. Based on the pore size, the investigated semi-IPNs can be regarded as macroporous. Thermogravimetric analysis showed that thermal stability of the semi-IPNs depends on the degree of crosslinking, as well as on the PEG content.

scholarly journals Influence of Poly(Ethylene Glycol) End Groups on Poly(Ethylene Glycol)-Albumin System Properties as a Potential Degradable Tissue Scaffold

2018 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Robyn Overby ◽  
Dale Feldman
Keyword(s):  
Ethylene Glycol ◽  
Crosslinking Agent ◽  
Poly Ethylene Glycol ◽  
In Vivo Evaluation ◽  
Tissue Scaffold ◽  
Handling Characteristics ◽  
Poly Ethylene ◽  
The Stability

Chronic dermal lesions, such as pressure ulcers, are difficult to heal. Degradable tissue scaffold systems can be employed to serve as a provisional matrix for cellular ingrowth and facilitate regenerative healing during degradation. Degradable regenerative tissue scaffold matrices can be created by crosslinking albumin with functionalized poly(ethylene glycol) (PEG) polymers. The purpose of this study was to evaluate the stability of PEG-albumin scaffold systems formed using PEG polymers with three different functionalized end chemistries by quantifying in vitro system swellability to determine the most promising PEG crosslinking polymer for wound healing applications. Of the three polymers evaluated, PEG-succinimidyl glutarate (SG) exhibited consistent gelation and handling characteristics when used as the crosslinking agent with albumin. PEG-SG polymers were identified as an appropriate synthetic crosslinking moiety in a PEG-albumin scaffold system, and further in vitro and in vivo evaluation of this scaffold system is merited.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

scholarly journals Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Medical Devices ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Wide Range ◽  
Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Biomaterials ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 247-258 ◽  
Author(s):  
A.A. Deschamps ◽  
A.A. van Apeldoorn ◽  
H. Hayen ◽  
J.D. de Bruijn ◽  
U. Karst ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
In Vitro Degradation ◽  
Butylene Terephthalate ◽  
Poly Ethylene ◽  
Ether Ester

In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action

2007 ◽  
Vol 341 (1-2) ◽  
pp. 50-57 ◽  
Author(s):  
Hoo-Kyun Choi ◽  
Myung-Kwan Chun ◽  
Se Hee Lee ◽  
Mee Hee Jang ◽  
Hee Doo Kim ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
In Vivo Study ◽  
Poly Ethylene Glycol ◽  
Duration Of Action ◽  
Poly Ethylene

Stabilization of L-Asparaginase Modified with Comb-Shaped Poly(ethylene glycol) Derivatives, in vivo and in vitro

1994 ◽  
Vol 5 (4) ◽  
pp. 283-286 ◽  
Author(s):  
Yoh Kodera ◽  
Taichi Sekine ◽  
Tohru Yasukohchi ◽  
Yoshihiro Kiriu ◽  
Misao Hiroto ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ethylene Glycol Derivatives
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