Performance of nuclear matrix protein 22 urine marker and voided urine cytology in the detection of urinary bladder tumors

2011 ◽  
Vol 49 (2) ◽  
Author(s):  
Tomaž Smrkolj ◽  
Miro Mihelič ◽  
Aleš Sedlar ◽  
Igor Sterle ◽  
Joško Osredkar ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Urine Cytology ◽  
Bladder Tumors ◽  
Nuclear Matrix Protein ◽  
Urine Marker

C118 Nuclear matrix protein 22 urinary marker in diagnosing and follow up of urinary bladder tumors

2009 ◽  
Vol 8 (8) ◽  
pp. 696
Author(s):  
T. Smrkolj ◽  
M. Mihelic ◽  
A. Sedlar ◽  
I. Sterle ◽  
J. Osredkar ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Bladder Tumors ◽  
Nuclear Matrix Protein ◽  
Urinary Marker

scholarly journals Use of the Nuclear Matrix Protein 22 BladderChek Test for the Detection of Primary and Recurrent Urothelial Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Chang-sheng Xia ◽  
Chun-hong Fan ◽  
Ming Su ◽  
Qing-song Wang ◽  
Hui-zhang Bao
Keyword(s):  
Urothelial Carcinoma ◽  
Sensitivity And Specificity ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Benign Disease ◽  
Urine Cytology ◽  
Nuclear Matrix Protein ◽  
Combined Use ◽  
Significant Difference ◽  
Low Sensitivity

Objective. To evaluate the performance of the nuclear matrix protein 22 (NMP22) BladderChek test in urothelial carcinoma (UC). Methods. We retrospectively analyzed 1318 patients who performed the NMP22 BladderChek tests. Of them, 103 were primary UC patients, 90 were surgical treatment UC patients, and 1125 were benign disease patients. The performance of the NMP22 BladderChek test for the diagnosis of primary and recurrent UC was evaluated. Moreover, the performance of urine cytology and the NMP22 BladderChek test for the diagnosis of primary UC was compared in 90 available subjects including 48 primary UC patients and 42 benign disease patients. Results. The sensitivity and specificity of the NMP22 BladderChek test were 37.9% and 95.8%, respectively, for the diagnosis of primary UC (n=1228). The corresponding parameters of the NMP22 BladderChek test were 31.0% and 88.5%, respectively, for the diagnosis of recurrent UC (n=90). The sensitivity and specificity of urine cytology were 54.2% and 97.6%, respectively, for the diagnosis of primary UC (n=90); the corresponding parameters of the NMP22 BladderChek test were 41.7% and 83.3%, respectively; the corresponding parameters of the two tests combination were 64.6% and 83.3%, respectively. There was a significant difference in the performance between the NMP22 BladderChek test and urine cytology or the combination of two tests (P=0.017 and 0.001, respectively). Conclusions. The NMP22 BladderChek test has a low sensitivity for detecting primary and recurrent UC. Urine cytology is superior to the NMP22 BladderChek test, and combined use of the two tests improves the sensitivity in the detection of primary UC.

Cytokeratin-20 immunocytochemistry in voided urine cytology and its comparison with nuclear matrix protein-22 and urine cytology in the detection of urothelial carcinoma

2011 ◽  
Vol 40 (9) ◽  
pp. 755-759 ◽  
Author(s):  
Ruchi Srivastava ◽  
Vinod Kumar Arora ◽  
Seema Aggarwal ◽  
Arati Bhatia ◽  
Navjeevan Singh ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Urine Cytology ◽  
Cytokeratin 20 ◽  
Nuclear Matrix Protein
Sign in / Sign up

Export Citation Format

Share Document