Pregnancy-associated plasma protein-A as a marker for long-term mortality in patients with peripheral atherosclerosis: inconclusive findings from the Linz Peripheral Arterial Disease (LIPAD) study

2010 ◽  
Vol 48 (4) ◽  
Author(s):  
Thomas Mueller ◽  
Benjamin Dieplinger ◽  
Thomas Forstner ◽  
Werner Poelz ◽  
Meinhard Haltmayer
Keyword(s):  
Peripheral Arterial Disease ◽  
Plasma Protein ◽  
Protein A ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Long Term Mortality

scholarly journals Site and Burden of Lower Limb Atherosclerosis Predicts Long-term Mortality in a Cohort of Patients With Peripheral Arterial Disease

2018 ◽  
Vol 56 (6) ◽  
pp. 849-856 ◽  
Author(s):  
Paul J.W. Tern ◽  
Izabela Kujawiak ◽  
Pratyasha Saha ◽  
Thomas B. Berrett ◽  
Mohammed M. Chowdhury ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Lower Limb ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Long Term Mortality

scholarly journals Initial Diastolic Dysfunction is a Powerful Predictor of 5-year Mortality in Peripheral Arterial Disease Patients undergoing Percutaneous Transluminal Angioplasty

2020 ◽  
Author(s):  
Kyung-Hee Kim ◽  
Seung Woon Rha ◽  
Byoung Geol Choi ◽  
Jae-Kyung Byun ◽  
Woohyeun Kim ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Percutaneous Transluminal Angioplasty ◽  
Independent Predictor ◽  
Arterial Disease ◽  
Transluminal Angioplasty ◽  
Total Death ◽  
Peripheral Arterial ◽  
Percutaneous Transluminal ◽  
Long Term Mortality

Abstract Background Peripheral arterial disease (PAD) and heart failure share common risks and are associated with increased morbidity and mortality. However, it is unknown whether cardiac function can be an independent predictor of long-term mortality in patients with PAD. Methods In total, 902 patients who underwent percutaneous transluminal angioplasty for PAD were enrolled. The patients were categorized into three groups according to the left ventricular ejection fraction (LVEF): reduced EF (< 40%, n = 62); mid-range EF (40–49%, n = 76); and preserved EF (≥ 50%, n = 764). Echocardiographic (EF, ratio of mitral inflow velocity to annular velocity E/eʹ ≥ 15, and others) and clinical parameters were tested using stepwise logistic regression analysis to determine independent predictors of 5-year mortality. Results A higher proportion of patients with reduced EF had ischemic heart disease than those with preserved EF (77.4% vs. 56.8%, p < 0.001). Up to 5 years, patients with reduced EF and mid-range EF showed a higher incidence of total death than those with normal EF. However, there was no difference in the incidence of myocardial infarction, stroke, and revascularization among the three groups. After multivariable adjustment, the ratio of E/eʹ ≥ 15 was the only strong predictor of total mortality (hazard ratio, 6.14; 95% confidence interval, 3.7–10.1;p < 0.01). Conclusion Patients with PAD and reduced EF undergoing PTA had a higher incidence of total death during the 5-year follow-up. Initial tissue Doppler E/eʹ ≥ 15, a non-invasive estimate of left atrial filling pressure, was the only independent predictor of long-term mortality.

scholarly journals Higher cystatin C level predicts long-term mortality in patients with peripheral arterial disease

2011 ◽  
Vol 216 (2) ◽  
pp. 440-445 ◽  
Author(s):  
Grazina Urbonaviciene ◽  
Guo Ping Shi ◽  
Sigitas Urbonavicius ◽  
Eskild W. Henneberg ◽  
Jes S. Lindholt
Keyword(s):  
Peripheral Arterial Disease ◽  
Cystatin C ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Long Term Mortality

scholarly journals Increased Pregnancy-Associated Plasma Protein-A as a Marker for Peripheral Atherosclerosis: Results from the Linz Peripheral Arterial Disease Study

2006 ◽  
Vol 52 (6) ◽  
pp. 1096-1103 ◽  
Author(s):  
Thomas Mueller ◽  
Benjamin Dieplinger ◽  
Werner Poelz ◽  
Meinhard Haltmayer
Keyword(s):  
Peripheral Arterial Disease ◽  
Plasma Protein ◽  
Protein A ◽  
Limb Ischemia ◽  
The Elderly ◽  
Arterial Disease ◽  
Atherosclerotic Disease ◽  
Entire Study ◽  
Coronary Syndrome ◽  
Peripheral Arterial

Abstract Background: The aim of the present investigation was to test the hypothesis that pregnancy-associated plasma protein-A (PAPP-A), a zinc-binding metalloproteinase implicated in acute coronary syndrome, is associated with atherosclerotic peripheral arterial disease (PAD). Methods: The study comprised 433 patients with symptomatic atherosclerotic PAD (i.e., chronic limb ischemia) and 433 controls matched to the patients with PAD in a 1:1 design by sex, age (±2 years), and diabetes mellitus status. Serum PAPP-A concentrations were measured with an enzymatically amplified 2-step sandwich-type immunoassay. Results: The entire study sample included 612 male and 254 female patients with a median age of 68 years. The median PAPP-A value was higher in the patients with PAD than in the referents (0.81 vs 0.64 mU/L; P &lt;0.001). After we adjusted for several possible confounding variables with multivariable logistic regression, odds ratios for PAD were 1.59 (95% confidence interval, 1.00–2.52; P = 0.049), 2.28 (1.45–3.61; P &lt;0.001), and 2.86 (1.78–4.59; P &lt;0.001) in the 2nd, 3rd, and 4th quartiles of serum PAPP-A concentrations compared with the first quartile. In the present study, PAPP-A added to the predictive value of other markers commonly in use. Conclusions: PAPP-A was associated with atherosclerotic PAD in the elderly sample studied. Because atherosclerotic PAD is considered an indicator of systemic atherosclerotic disease in elderly patients, the present results indicate that circulating PAPP-A may be a marker for systemic atherosclerotic disease.

scholarly journals Evaluation of sCD163 and sTWEAK in patients with stable peripheral arterial disease and association with disease severity as well as long-term mortality

2021 ◽  
Vol 317 ◽  
pp. 41-46
Author(s):  
Daniel Mrak ◽  
Bernhard Zierfuss ◽  
Clemens Höbaus ◽  
Carsten Thilo Herz ◽  
Gerfried Pesau ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Disease Severity ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Long Term Mortality
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