Establishment of reference distributions and decision values for thyroid antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TgAb) and the thyrotropin receptor (TRAb)

2006 ◽  
Vol 44 (8) ◽  
Author(s):  
Esther A. Jensen ◽  
Per Hyltoft Petersen ◽  
Ole Blaabjerg ◽  
Pia Skov Hansen ◽  
Thomas H. Brix ◽  
...  
Keyword(s):  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Thyrotropin Receptor ◽  
Reference Distributions

AbstractClin Chem Lab Med 2006;44:991–8.

THYROID ANTIBODIES LEVELS IN EUTHYROID MEN AND WOMEN - RESIDENTS OF THE ARCTIC ZONE OF THE RUSSIAN FEDERATION

2019 ◽  
Vol 64 (9) ◽  
pp. 541-545
Author(s):  
I. N. Gorenko
Keyword(s):  
Russian Federation ◽  
Clinical Importance ◽  
Thyroid Function Test ◽  
The Arctic ◽  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Arctic Zone ◽  
Men And Women ◽  
Autoimmune Thyroid ◽  
The Russian Federation

The aim of the study was to determine the levels of thyroid antibodies and their relationship with thyroid hormones and thyroglobulin in euthyroid men and women, residents of the Arctic zone of the Russian Federation. A total of 208 apparently healthy people were enrolled in this study and classified into two groups depending on gender and level of autoantibodies in the blood. Serum hormones of the pituitary-thyroid system, thyroglobulin and antibodies concentration was measured by enzyme immunoassay. The prevalence of positive antibodies among various examined groups was determined and the characteristics of euthyroid subjects with abnormal thyroid antibodies levels were studied. Circulating positive thyroid antibodies were found in 20% of the surveyed residents of the Arctic zone of the Russian Federation. The median serum antibodies against thyroid peroxidase (AntiTPO) or thyroglobulin (AntiTG) levels and the percentage of people in general population with positive antibodies (i.e. AntiTPO ≥ 50 IU / ml and / or AntiTG ≥ 100 IU / ml) were statistically significant higher in women than in men, p < 0.01. Such thyroid antibodies levels were associated with a higher thyroid gland functional activity in women, which was demonstrated by significantly higher thyroxin level and lower thyroglobulin value in the peripheral blood. Part of women positive for AntiTPO increased with age from 18 to 33% (in groups aged 18-44 and 45-59 years, p = 0.04). The findings of the study reveal correlation between thyroid function test and thyroid antibodies levels, elaborating the clinical importance of thyroid antibodies in clinical examination and follow-up of patients with autoimmune thyroid disorders.

scholarly journals Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study

2008 ◽  
Vol 158 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Inge Bülow Pedersen ◽  
Peter Laurberg ◽  
Nils Knudsen ◽  
Torben Jørgensen ◽  
Hans Perrild ◽  
...  
Keyword(s):  
Population Study ◽  
Age Groups ◽  
Negative Association ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Thyroid Antibodies ◽  
Autoimmune Thyroid Diseases ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Autoimmune Thyroid

BackgroundAutoimmune thyroid diseases are common and the prevalence of circulating thyroid antibodies (thyroid peroxidase antibody, TPO-Ab and thyroglobulin antibody, Tg-Ab) is high in the population. The knowledge of a possible association between lifestyle factors and circulating thyroid antibodies is limited.AimTo evaluate the correlation between smoking habits and the presence of circulating TPO-Ab and Tg-Ab.Material and methodsIn a cross-sectional comparative population study performed in two areas of Denmark with moderate and mild iodine deficiency, 4649 randomly selected subjects from the population in some predefined age groups between 18 and 65 years were examined. Blood tests were analysed for TPO-Ab and Tg-Ab using assays based on the RIA technique. The participants answered questionnaires, were clinically examined and blood and urine samples collected.ResultsData were analysed in multivariate logistic regression models. There was a negative association between smoking and the presence of thyroid autoantibodies in serum. This association was observed for the presence of TPO-Ab and/or Tg-Ab, TPO-Ab (without respect to Tg-Ab status), Tg-Ab (without respect to TPO-Ab status) and both antibodies together. The association between smoking and thyroid autoantibodies was stronger for Tg-Ab than for TPO-Ab. There was no association between smoking and TPO-Ab measured alone or between smoking and TPO-Ab when Tg-Ab was included in the model as an explanatory variable.ConclusionSmoking was negatively associated with the presence of thyroid autoantibodies with the strongest association between smoking and Tg-Ab. The study design precludes any conclusions as to the cause of the negative association between smoking thyroid autoantibodies.

Thyroid evaluation of children and adolescents with Williams syndrome in Zhejiang Province

2017 ◽  
Vol 30 (12) ◽  
Author(s):  
Wei-Jun Chen ◽  
Chai Ji ◽  
Dan Yao ◽  
Zheng-Yan Zhao
Keyword(s):  
Children And Adolescents ◽  
Thyroid Function ◽  
Williams Syndrome ◽  
Subclinical Hypothyroidism ◽  
Thyroid Stimulating Hormone ◽  
Zhejiang Province ◽  
Overt Hypothyroidism ◽  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Free Triiodothyronine

AbstractBackground:The objective of the study was to describe the prevalence of abnormal thyroid function and volume in children and adolescents with Williams syndrome (WS) in Zhejiang Province, China.Methods:Thyroid function, including thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and thyroid antibodies (thyroid peroxidase and thyroglobulin) were measured in 83 patients with WS, aged 0.2–16.5 years. Twenty-three patients were followed for an average of 1.7 years (0.4–4.1), and multiple TSH determinations were considered. Thyroid ultrasonography was performed on 49 patients.Results:One patient was diagnosed with overt hypothyroidism, and 23 patients (27%) had subclinical hypothyroidism (SH). Thyroid antibodies were absent in all patients. In five age groups (0–1 years, 1–3 years, 3–6 years, 6–9 years, 9–18 years), the prevalence of patients with subclinical hypothyroidism was 25%, 28.5%, 44.4%, 16.7% and 4.7%, respectively. Through ultrasound examination, 21 patients (42%) were observed to have thyroid hypoplasia (TH), and there were no cases of thyroid haemiagenesis. The incidence rate of TH increased with age, rising from 20% in the youngest group to 66% in the oldest.Conclusions:SH and TH is common in children and adolescents with WS. Yearly evaluation of thyroid must be performed in all patients in this population, regardless of the result of the neonatal screening. Age under 6 years and existing thyroid abnormalities are risk factors for developing SH, and a shorter follow-up interval is needed for screening in these individuals, SH is often self-limiting, and clinicians should be alert to overt hypothyroidism.

Thyroid function and autoimmune manifestations in insulin-dependent diabetes mellitus during and after pregnancy

1991 ◽  
Vol 124 (5) ◽  
pp. 534-539 ◽  
Author(s):  
Karine Bech ◽  
Mimi Høier-Madsen ◽  
Ulla Feldt-Rasmussen ◽  
Bente Møller Jensen ◽  
Lars Mølsted-Pedersen ◽  
...  
Keyword(s):  
Antibody Titre ◽  
Thyroid Function ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Postpartum Thyroiditis ◽  
Thyroid Stimulating Antibody ◽  
Insulin Dependent ◽  
Pregnant Diabetic

Abstract. Insulin-dependent diabetes is associated with other autoimmune diseases and subclinical hypothyroidism has been reported in pregnant diabetic women. We studied the thyroid function of 85 women with diabetes during pregnancy and after delivery, as well as various autoantibodies. During pregnancy, thyroid microsomal antibodies were present in 17/85, antibodies against thyroid peroxidase in 16/85, thyroglobulin antibodies in 2/85, parietal cell antibodies in 23/85, adrenal antibodies in 4/77, rheumatoid factor in 15/85, and thyroid-stimulating antibodies in 43/85. Presence of antibodies was not combined with thyroid dysfunction, but TSH and HbA1c was increased (p<0.005) in women with thyroid antibodies. The gestational age of the infants was lower (p<0.01) in women with positive thyroid-stimulating antibody titre, whereas the ponderal index was only lower in those with peroxidase antibodies (p<0.05). After delivery, microsomal and peroxidase antibodies were positive in 10 (17.5%) of 57 patients followed. Six women developed postpartum thyroiditis (10.5%), of whom 5 were positive for both microsomal and peroxidase antibodies; two of those showing a hyperthyroid phase also had positive thyroid-stimulating antibody titre. We conclude that autoantibodies occur with increased incidence in pregnant diabetic women. Thyroid antibodies are related to a slightly reduced thyroid capacity and involve a high risk of postpartum thyroiditis. Further, thyroid antibodies seem to influence the nutritional status of the infant.

Lipoprotein(a) increase associated with thyroid autoimmunity

1997 ◽  
Vol 136 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Helga Lotz ◽  
Giovanni B Salabè
Keyword(s):  
Thyroid Autoimmunity ◽  
Serum Levels ◽  
Serum Lipoprotein ◽  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Normal Range ◽  
Thyroid Status ◽  
Lipoprotein A ◽  
Thyroglobulin Antibody ◽  
Hypothyroid Patients

Abstract Conflicting results have been reported regarding serum lipoprotein(a) (Lp(a)) concentrations in patients with hypothyroidism. We addressed the question whether thyroid autoimmunity could be associated with elevated Lp(a) values independent of the thyroid status. Lp(a) was measured by ELISA in 30 males, 29 premenopausal and 30 postmenopausal females positive for thyroid peroxidase- and/or thyroglobulin-antibody (T-Abs) and normolipidemic, screened out respectively from 428 male donors, 162 premenopausal donors and 108 postmenopausal females; they were compared with 65 males, 72 premenopausal and 48 postmenopausal females, negative for thyroid antibodies, normolipidemic and matched for age. T-Abs-positive male donors showed serum Lp(a) concentrations significantly increased compared with males without T-Abs (mean 19·7 ± 15·9 vs 12·7 ± 17·5 mg/dl; median 17·0 vs 4·0 mg/dl; Mann Whitney U test: P = 0·0000). In premenopausal females no difference could be found between T-Abs-positive and T-Abs-negative subjects (mean 13·2 ± 16·1 vs 12·3 ± 13·9 mg/dl; median 5·2 vs 8·7 mg/dl), suggesting an Lp(a) lowering effect of estrogens. The study was, therefore, extended to postmenopausal females. Significantly elevated Lp(a) levels were found in 30 postmenopausal females with T-Abs when compared with 48 postmenopausal females without T-Abs (40·0 ± 34·2 mg/dl vs 20·7 ± 19·3 mg/dl; median 32·0 vs 18·0 mg/dl; Mann Whitney U test: P = 0·0002). Finally, 21 postmenopausal, normolipidemic, autoimmune hypothyroid patients on l-thyroxine and euthyroid compared with 48 postmenopausal females without T-Abs also showed increased serum levels of Lp(a) (mean 27·0 ± 16·8 mg/dl vs 20·7 ± 19·3 mg/dl, median 25·0 vs 18 mg/dl; Mann Whitney U test: P = 0·0024). Thyrotropin levels in all subjects and patients were within the normal range. In conclusion, our results in males and postmenopausal females with T-Abs and euthyroid show an association between thyroid autoimmunity and increased levels of Lp(a), while the results obtained in premenopausal females suggest that estrogens might interfere with the Lp(a) increase related to thyroid autoimmunity. European Journal of Endocrinology 136 87–91

scholarly journals Prevalence of Thyroid Abnormalities in Thai Patients with Vitiligo

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Vasanop Vachiramon ◽  
Sarawin Harnchoowong ◽  
Woranit Onprasert ◽  
Kumutnart Chanprapaph
Keyword(s):  
Thyroid Function Test ◽  
Female Gender ◽  
Thyroid Diseases ◽  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Dermatology Clinic ◽  
Thyroid Abnormalities ◽  
Serum Tsh

Background. Vitiligo is an acquired hypopigmentary disorder. The prevalence of vitiligo is 0.1–2% worldwide. Numerous autoimmune diseases are associated with vitiligo, including autoimmune thyroid diseases. The prevalence of thyroid abnormalities is up to 34% in vitiligo patients depending on ethnicities. Objective. This study aims to investigate thyroid abnormalities in Thai patients with vitiligo. Methods. Medical records of vitiligo patients attending outpatient dermatology clinic at a university-based hospital from 2012 to 2016 were retrospectively reviewed. Data regarding vitiligo, clinical features, and autoimmune thyroid laboratory results were retrieved and analyzed. Results. Among 325 vitiligo patients identified, anti-thyroid peroxidase and anti-thyroglobulin were positive in 90 (27.7%) and 63 patients (19.4%), respectively. Positive thyroid antibody was associated with female gender (p<0.001) and vitiliginous hand lesions (p<0.02). Out of 197 patients with complete thyroid function test, the prevalence of autoimmune thyroid diseases (AITD) is 12.7%. Female, nonsegmental type, higher affected area, and the presence of leukotrichia are significantly associated with AITD in vitiligo patients. Conclusions. Prevalence of positive thyroid antibodies and AITD in Thai patients with vitiligo is compatible with previous studies around the world. Screening for AITD with thyroid antibodies and serum TSH is essential for vitiligo patients.

scholarly journals Association of thyroid antibodies status on the outcomes of pregnant women with hypothyroidism (maternal hypothyroidism on pregnancy outcomes, MHPO-4)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zareen Kiran ◽  
Aisha Sheikh ◽  
Najmul Islam
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Gestational Hypertension ◽  
Neonatal Outcomes ◽  
Reproductive Age ◽  
Independent Effect ◽  
Thyroid Peroxidase ◽  
Thyroid Antibodies ◽  
Thyroid Peroxidase Antibodies ◽  
Maternal And Neonatal Outcomes

Abstract Background Autoimmunity increases with age and is often commonly evaluated in women of the reproductive age group. Prevalence of thyroid antibodies is common even in euthyroid pregnant women. We aim to compare the association of thyroid antibody status on the maternal and neonatal outcomes in pregnant women with hypothyroidism. Methods We conducted a cross-sectional retrospective study on 718 cases in the Aga Khan University Hospital. Information was collected on pregnant women who have been diagnosed with hypothyroidism before conception or during their antenatal period. Laboratory data were recorded for thyroid peroxidase antibodies, anti-thyroglobulin antibodies, and thyroid-stimulating hormone levels. Maternal and neonatal outcomes were also noted from medical file records. Data analysis was performed on Statistical Package for the Social Sciences version 20.0. Results Overall, 146 out 718 cases were included for final analysis. Thyroid peroxidase antibodies were positive in 66.4% and anti-thyroglobulin was positive in 52.1% cases, whereas 43.8% of cases had both antibodies positive. Pre-gestational diabetes was significantly associated with thyroid autoimmunity. There was a 73% less chance of gestational hypertension for thyroid autoimmune groups. Gestational diabetes and maternal (chronic) hypertension were found to have an independent effect on postpartum hemorrhage. Hypertensive disorders in pregnancy were found to have an independent risk for premature birth. Conclusion Our study reports a 74.7% prevalence of positive thyroid antibodies in hypothyroid pregnant women, with higher association with pre-gestational diabetes. Gestational hypertension was least likely to occur in thyroid autoimmune groups. None of the outcomes were independently associated with worse outcomes.

scholarly journals CARRIAGE OF THYROID ANTIBODIES AS A RISK FACTOR IN THE DEVELOPMENT AND PROGRESSION OF ENDOCRINE OPHTHALMOPATHY

2017 ◽  
Vol 25 (2) ◽  
pp. 270-278
Author(s):  
V. G. Likhvantseva ◽  
M. S. Afanasyev ◽  
E. A. Rudenko ◽  
С. С. Afanasyev ◽  
E. V. Korosteleva ◽  
...  
Keyword(s):  
Risk Factor ◽  
Clinical Course ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Thyroid Antibodies ◽  
Increased Risk ◽  
Endocrine Ophthalmopathy ◽  
Toxic Goiter ◽  
Stimulating Hormone

The influence of the carrier of thyroid autoantibodies (to thyroid-stimulating hormone receptor, to thyroglobulin, to thyroid peroxidase) on the clinical course of endocrine ophthalmopathy (EOP), developed on the background of diffuse toxic goiter (139 patients). We studied the role of carrier of monoantibodies and their combinations. It has been proven a direct link between the presence of the analyzed thyroid autoantibodies and the clinical course of EOP. It is shown that the presence of antibodies to thyroid peroxidase and anti-thyroglobulin antibodies is not a lesser important risk factor for the development of EOP in patients with diffuse toxic goiter than the presence of antibodies to the receptor for thyroid-stimulating hormone, and the multiple carriers is associated with more frequent development of active forms of EOP and higher amplitude of inflammation of the orbit. Thus, serological indices and spectrum of thyroid antibodies revealed the depth of systemic disorders of autoimmunity, associated with an increased risk of the development of local autoimmune inflammation in the orbit and can serve as prognostic risk markers of development of highly active and severe forms of EOP.

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