Steroids, Sex Hormone-Binding Globulin, Homocysteine, Selected Hormones and Markers of Lipid and Carbohydrate Metabolism in Patients with Severe Hypothyroidism and Their Changes Following Thyroid Hormone Supplementation

2003 ◽  
Vol 41 (3) ◽  
Author(s):  
Marie Bičíková ◽  
Richard Hampl ◽  
Martin Hill ◽  
Soňa Stanická ◽  
Jaroslava Tallová ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Carbohydrate Metabolism ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans

1995 ◽  
Vol 132 (5) ◽  
pp. 594-598 ◽  
Author(s):  
Sonia C Dumoulin ◽  
Bertrand P Perret ◽  
Antoine P Bennet ◽  
Philippe J Caron
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Steroid Hormones ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Thyroid Status ◽  
Corticosteroid Binding Globulin ◽  
Hypothyroid Patients ◽  
Hyperthyroid Patients

Dumoulin SC, Perret BP, Bennet AP, Caron PJ. Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans. Eur J Endocrinol 1995;132:594–8. ISSN 0804–4643 Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). The SHBG levels are increased in hyper- and decreased in hypothyroid patients, whereas CBG levels are increased in hypo- and decreased in hyperthyroid patients. The SHBG levels are higher in women than in men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients, SHBG concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In hyperthyroid patients, SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01) during antithyroid treatment. The SHBG and CBG concentrations in treated hypo- and hyperthyroid patients were not significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid status. Corticosteroid-binding globulin is an index of thyroid hormone action at the liver level whose changes are opposite to those of SHBG in hyper- and hypothyroidism. Philippe Caron, Service d'Endocrinologie et Maladies Métaboliques, CHU Rangueil, 1 Avenue J Poulhès, 31054 Toulouse Cedex, France

Alterations of serum concentrations of thyroid hormones and sex hormone-binding globulin, nuclear binding of tri-iodothyronine and thyroid hormone-stimulated cellular uptake of oxygen and glucose in mononuclear blood cells from patients with non-thyroidal illness

1990 ◽  
Vol 124 (3) ◽  
pp. 495-499 ◽  
Author(s):  
J. Kvetny ◽  
L. Matzen
Keyword(s):  
Oxygen Consumption ◽  
Thyroid Hormone ◽  
Glucose Uptake ◽  
Blood Cells ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Control Group ◽  
Hormone Binding ◽  
Mononuclear Blood Cells ◽  
In Cells

ABSTRACT Nuclear tri-iodothyronine (T3) binding and thyroid hormone-stimulated oxygen consumption and glucose uptake were examined in mononuclear blood cells from patients with non-thyroidal illness (NTI) in which serum T3 was significantly (P < 0·05) depressed (0·62± 0·12 (s.d.) nmol/l) compared with healthy control subjects (1·45 ± 0·30 nmol/l). Neither serum TSH nor sex hormone-binding globulin differed from that of the control group. Nuclear T3 binding capacity was increased (P < 0·05) in patients with NTI (10·1 ± 3·0 fmol/100 μg DNA) compared with controls (2·5 ± 0-9 fmol/100 μg DNA). Unstimulated glucose uptake was increased in cells from patients with NTI (2·03 ± 0·49 mmol/l per mg DNA per h, P < 0·01) compared with controls (1·13 ± 0·20 mmol/l per mg DNA per h). Thyroxine-stimulated glucose uptake (stimulated glucose uptake–unstimulated glucose uptake) was increased in cells from patients with NTI (2·06 ± 1·67 mmol/l per mg DNA per h, P < 0·01) compared with controls (0·26 ± 0·1 mmol/l per mg DNA per h), and T3-stimulated glucose uptake was also increased in cells from patients with NTI (1·34 ± 0·81 mmol/l per mg DNA per h, P < 0·05) compared with controls (0·24 ± 0·10 mmol/l per mg DNA per h). In contrast, neither unstimulated nor thyroid hormone-stimulated oxygen consumption differed. We conclude that both increased nuclear T3 binding and increased thyroid hormone-induced glucose uptake may represent counter-regulatory mechanisms which tend to maintain intracellular homeostasis. Journal of Endocrinology (1990) 124, 495–499

Thyroid hormone turnover in patients with small cell carcinoma of the lung

1988 ◽  
Vol 118 (3) ◽  
pp. 460-464 ◽  
Author(s):  
Jens Faber ◽  
Sven Poulsen ◽  
Per Iversen ◽  
Carsten Kirkegaard
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Transit Time ◽  
Mean Transit Time ◽  
Small Cell ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Abstract. Patients with small cell carcinoma of the lung often present with symptoms suggestive of hyperthyroidism i.e. weight loss without anorexia. Consequently [125I]T4 and [131I]T3 turnover was studied using simultaneously iv bolus injection and noncompartmental analysis in 6 patients with untreated small cell carcinoma of the lung and 14 normal subjects of comparable ages. Both T4 and T3 production rates were enhanced, T4 production being in median 135 nmol · day−1 · 70 kg−1 (range 111–200) in patients with small cell carcinoma of the lung vs 98 nmol·day−1 ·70 kg−1 (range 69–134) in controls (P < 0.01), and T3 production being 46 nmol · day−1·70 kg−1 (range 33–65) vs 31 nmol ·day−1 ·70 kg−1 (range 24–45) (P < 0.01). The mean transit time was shortened for both T4 and T3, T4 mean transit time being 5.9 days (3.9–8.0 days) vs 8.3 days (6.1–11.2 days) in controls (P < 0.01), and T3 mean transit time being 0.74 days (0.36–0.98 days) vs 1.03 days (0.81–1.45 days) in controls (P < 0.01). Serum total and free T4 and T3 levels were unchanged. Basal serum TSH levels and the TSH response to iv TRH were also normal. Thyroid-stimulating immunoglobulins were only present in the serum in 1 of 6 patients. Thus, thyroid hormone production seemed under pituitary regulation. The peripheral effect of thyroid hormones was evaluated measuring serum sex hormone binding globulin levels, which were increased to in median 270% (77–310%) (P < 0.01) of that in controls, suggesting some degree of hyperthyroidism in liver tissue. One patient was re-investigated after complete remission, which resulted in normalization of T4 and T3 production and mean transit time, as well as serum sex hormone binding globulin levels. The data demonstrate that patients with untreated small cell carcinoma of the lung have enhanced turnover of thyroid hormones, a pattern quite different from that usually seen in non-thyroidal somatic illness.

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