Inflammatory Response to Coronary Stent Implantation in Patients with Unstable Angina

2002 ◽  
Vol 40 (8) ◽  
Author(s):  
Víctor Sánchez-Margalet ◽  
José M. Cubero ◽  
Consuelo Martín-Romero ◽  
José Cubero ◽  
José M. Cruz-Fernández ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Unstable Angina ◽  
Stent Implantation ◽  
Coronary Stent ◽  
Coronary Stent Implantation

Expression of activation molecules in neutrophils, monocytes and lymphocytes from patients with unstable angina treated with stent implantation

2004 ◽  
Vol 42 (3) ◽  
Author(s):  
Víctor Sánchez-Margalet ◽  
José M. Cubero ◽  
Consuelo Martín-Romero ◽  
José Cubero ◽  
José M. Cruz-Fernández ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Inflammatory Response ◽  
Cell Surface ◽  
Unstable Angina ◽  
Stent Implantation ◽  
Coronary Angioplasty ◽  
Coronary Stent ◽  
Activation Markers ◽  
Coronary Stent Implantation ◽  
Monocytes And Lymphocytes

AbstractCoronary angioplasty is known to mediate an inflammatory response. Recently, we have characterized the transient systemic inflammatory response after coronary stent implantation in patients with unstable angina by measuring different soluble protein markers. In the present study we have characterized the expression of various cellular activation markers in neutrophils, monocytes and lymphocytes from the same group of patients. Peripheral blood samples were taken before and 24 h, 48 h and 7 days after successful coronary stenting in 58 patients. Cell surface markers (CD11b/CD18 and CD38) were analyzed by flow cytometry to determine the activation of neutrophils, monocytes and T lymphocytes. We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days. However, T lymphocytes were not found to be activated. These results suggest that coronary stent implantation induces a different pattern inducing soluble and cellular inflammation markers, and therefore, they should be taken into account in patients undergoing stent implantation to study clinical correlations.

Enhanced inflammatory response following coronary stent implantation in stable angina patients

2007 ◽  
Vol 118 (1) ◽  
pp. 69-75
Author(s):  
Carlos V. Serrano ◽  
Elise S. Santos ◽  
José A. Mangione ◽  
Morton Scheinberg ◽  
Juliana S. Souza ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Stent Implantation ◽  
Stable Angina ◽  
Coronary Stent ◽  
Coronary Stent Implantation
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