The Effects of Marathon Swimming on Serum Leptin and Plasma Neuropeptide Y Levels

2002 ◽  
Vol 40 (2) ◽  
Author(s):  
Ioannis Karamouzis ◽  
Michael Karamouzis ◽  
Ioannis S. Vrabas ◽  
Kosmas Christoulas ◽  
Nikitas Kyriazis ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Serum Leptin ◽  
Marathon Swimming

Prenatal exposure to glucocorticoids affects body weight, serum leptin levels, and hypothalamic neuropeptide‐Y expression in pre‐pubertal female rat offspring

2014 ◽  
Vol 36 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Munkhsaikhan Munkhzaya ◽  
Altankhuu Tungalagsuvd ◽  
Takako Kawami ◽  
...  
Keyword(s):  
Body Weight ◽  
Neuropeptide Y ◽  
Prenatal Exposure ◽  
Female Rat ◽  
Serum Leptin ◽  
Rat Offspring

The role of photoperiod on the expression of hypothalamic genes regulating appetite in Chevrier’s field mouse (Apodemus chevrieri)

2015 ◽  
Vol 65 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Lin Zhang ◽  
Fang Yang ◽  
Jinhong Cai ◽  
Chunmei Huang ◽  
Zhengkun Wang ◽  
...  
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Mrna Expression ◽  
Physiological Role ◽  
Field Mouse ◽  
Related Protein ◽  
Serum Leptin ◽  
Significant Difference ◽  
Agouti Related Protein

The hypothalamus and leptin play a key role in the regulation of food intake. The present study investigated the effects of 4 weeks of short- or long-photoperiod on serum leptin levels and food intake in relation to mRNA expression levels of neuropeptide Y, agouti-related protein, pro-opiomelanocortin, and cocaine- and amphetamine-regulated transcript in the hypothalamus of Chevrier’s field mouse (Apodemus chevrieri). There was a significant difference in body fat mass, food intake and neuropeptide Y mRNA expression between the two groups, but serum leptin level, agouti-related protein, pro-opiomelanocortin, and cocaine- and amphetamine-regulated transcript mRNA expression in the hypothalamus were not difference between the two groups. The elevation of neuropeptide Y mRNA regulated neuropeptides in the hypothalamus suggests a physiological role of neuroendocrine factors in food intake during the different photoperiod. We conclude that leptin may be involved in energy balance and body mass regulation.

Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat

2001 ◽  
Vol 92 (1-2) ◽  
pp. 28-36 ◽  
Author(s):  
J.B Furness ◽  
H.S Koopmans ◽  
H.L Robbins ◽  
N Clerc ◽  
J.M Tobin ◽  
...  
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Serum Leptin

Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels

2000 ◽  
Vol 14 (3) ◽  
pp. 196-203 ◽  
Author(s):  
A. Milewicz ◽  
B. Bidzinska ◽  
E. Mikulski ◽  
M. Demissie ◽  
U. Tworowska
Keyword(s):  
Neuropeptide Y ◽  
Menopausal Status ◽  
Serum Leptin

Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression

1998 ◽  
Vol 275 (3) ◽  
pp. E405-E411 ◽  
Author(s):  
Hua Li ◽  
Michael Matheny ◽  
Nihal Tümer ◽  
Philip J. Scarpace
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Neuropeptide Y ◽  
Mrna Levels ◽  
Aged Rats ◽  
Serum Leptin ◽  
Epididymal White Adipose Tissue ◽  
Ad Libitum ◽  
Fasted Rats

To investigate the role of aging on the fasting-induced suppression of leptin gene expression and increase in hypothalamic neuropeptide Y (NPY) gene expression, we fasted or fed ad libitum male F-344xBN rats aged 3, 24, and 31 mo for 2 days. We examined leptin mRNA levels in retroperitoneal, inguinal, and epididymal white adipose tissue (WAT); serum leptin levels; and NPY mRNA levels in the hypothalamus. We found that leptin mRNA levels were increased from 3 to 24 mo and leveled off between 24 and 31 mo in both retroperitoneal WAT and inguinal WAT but were unchanged with age in epididymal WAT. Serum leptin levels increased with age, whereas hypothalamic NPY mRNA levels did not change with age. Fasting suppressed leptin gene expression in all three WATs and serum leptin. Moreover, this suppression of serum leptin and of leptin message in retroperitoneal WAT was less in aged rats. Conversely, fasting increased hypothalamic NPY message, again to a lesser extent in aged rats. In both fed (ad libitum) and fasted rats, there was a strong correlation between serum leptin and hypothalamic NPY mRNA levels in the young but not in either of the two aged groups. These data suggest that aged F-344xBN rats are leptin resistant and that the fasting regulation of serum leptin, leptin mRNA, and hypothalamic NPY mRNA is impaired in aged rats.

scholarly journals Diurnal changes in hypothalamic neuropeptide and SOCS-3 expression: effects of lactation and relationship with serum leptin and food intake

2004 ◽  
Vol 183 (1) ◽  
pp. 173-181 ◽  
Author(s):  
R G P Denis ◽  
C Bing ◽  
S Brocklehurst ◽  
J A Harrold ◽  
R G Vernon ◽  
...  
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Diurnal Changes ◽  
Diurnal Pattern ◽  
Serum Leptin ◽  
Related Peptide ◽  
Mrna Ratio ◽  
Feedback Inhibitor ◽  
Nocturnal Increase ◽  
Induced Changes

Rats normally eat about 85% of their food at night. Lactation increases food intake 3- to 4-fold, but the diurnal pattern of food intake persists. The mechanisms responsible for the diurnal and lactation-induced changes in food intake are still unresolved, hence we have further investigated the possible roles of serum leptin and hypothalamic expression of neuropeptide Y (NPY), agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) in rats. Suppressor of cytokine signalling-3 (SOCS-3) acts as a feedback inhibitor of leptin signalling in the hypothalamus, hence changes in expression of SOCS-3 were also investigated. Changes in expression of NPY, AgRP or POMC alone could not account for the diurnal changes in intake and their alteration by lactation. However, there were increased AgRP mRNA:POMC mRNA ratios at night and also during lactation, which were very similar to estimated changes in food intake. Such changes in expression may result in dominance of the orexigenic AgRP peptide over the appetite-suppressing POMC-derived peptides, and so could contribute to the hyperphagia in these states. Diurnal and lactation-related changes in the AgRP mRNA:POMC mRNA ratio and food intake are not due to changes in leptin alone. However, hypoleptinaemia, possibly through increased expression of NPY, may contribute to the hyperphagia of lactation. In the dark, expression of SOCS-3 was decreased in non-lactating rats; lactation decreased SOCS-3 expression in both light and dark phases. However, such changes are likely to enhance the ability of leptin-responsive neurones to transmit the leptin signal, and so are unlikely to contribute to either the nocturnal increase in appetite or the hyperphagia of lactation.

scholarly journals Berberine for Appetite Suppressant and Prevention of Obesity

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hyun-Jung Park ◽  
EunYee Jung ◽  
Insop Shim
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Neuropeptide Y ◽  
Glucose Level ◽  
Serum Glucose ◽  
Chow Diet ◽  
Serum Leptin ◽  
Appetite Suppressants ◽  
Artificial Cerebrospinal Fluid ◽  
Normal Chow

Berberine (BBR), a natural plant product, has been shown to have antidiabetic, cholesterol-reducing effects. To investigate the action of BBR as appetite suppressants, two experimental protocols were performed. In the first experiment, the mice were fed either a normal-chow diet or a high-fat diet (HF). The mice received daily intraperitoneal injections of BBR (10 mg/kg or saline at 1 ml/kg) for 3 weeks. To determine the antiobesity effects of BBR, the food consumption, body weight, fat contents, serum leptin, and glucose level were investigated. In the second experiment, we set out to validate the effect of BBR on central neuropeptide Y (NPY) stimulated rats. Experiments were carried out in 24-hour fasted rats, and then food intake and glucose level were subsequently recorded for 1 hour. The experimental groups were subdivided into the intra-3rd ventricular microinjections of ACSF (artificial cerebrospinal fluid), neuropeptide Y (NPY; 100 nM), NPY+BBR (10 nM), and NPY+BBR (100 nM) group. And then the blood glucose level was examined. In the first experiment, treatment with BBR in the HF diet mice reduced food intake, body weight, fat contents, serum leptin, and glucose level. In the second experiment, the NPY-injected group increased food intake by 39.3%, and food intake was reduced in the BBR group by 47.5%, compared with the ACSF-injected group. Also, the serum glucose level in the NPY+BBR (100 nM) group was significantly lower than that in the NPY (100 nM) group. The results suggest that BBR improved lipid dysregulation in obesity by controlling the central obesity related pathway.

Changes in the responsiveness of serum leptin and hypothalamic neuropeptide Y mRNA levels to food deprivation in developing rats

2011 ◽  
Vol 29 (4) ◽  
pp. 377-380 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Riyo Kinouchi ◽  
Ganbat Gereltsetseg ◽  
Masahiro Murakami ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Food Deprivation ◽  
Mrna Levels ◽  
Serum Leptin
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