Presence of Group IIa Secretory Phospholipase A2 in Mast Cells and Macrophages in Normal Human Ileal Submucosa and in Crohn's Disease

2000 ◽  
Vol 38 (12) ◽  
Author(s):  
Ingela Lilja ◽  
Christina Gustafson-Svärd ◽  
Lars Franze'n ◽  
Rune Sjödahl ◽  
Sonja Andersen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Mast Cells ◽  
Crohn's Disease ◽  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Normal Human

scholarly journals Detection of secretory phospholipase A2 s related but not identical to type IIA isozyme in cultured mast cells

FEBS Letters ◽  
1997 ◽  
Vol 413 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Makoto Murakami ◽  
Kinji Tada ◽  
Satoko Shimbara ◽  
Terumi Kambe ◽  
Hisashi Sawada ◽  
...  
Keyword(s):  
Mast Cells ◽  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase

scholarly journals Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic function in human lung-derived cells

2005 ◽  
Vol 387 (1) ◽  
pp. 27-38 ◽  
Author(s):  
Seiko MASUDA ◽  
Makoto MURAKAMI ◽  
Michiko MITSUISHI ◽  
Kazuo KOMIYAMA ◽  
Yukio ISHIKAWA ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Human Lung ◽  
Cell Types ◽  
Interferon Γ ◽  
Secretory Phospholipase A2 ◽  
Group V ◽  
Secretory Phospholipase ◽  
Human Lungs ◽  
Normal Human ◽  
Lung Pathogenesis

Although a number of sPLA2 (secretory phospholipase A2) enzymes have been identified in mammals, the localization and functions of individual enzymes in human pathologic tissues still remain obscure. In the present study, we have examined the expression and function of sPLA2s in human lung-derived cells and in human lungs with pneumonia. Group IID, V and X sPLA2s were expressed in cultured human bronchial epithelial cells (BEAS-2B) and normal human pulmonary fibroblasts with distinct requirement for cytokines (interleukin-1β, tumour necrosis factor α and interferon-γ). Lentivirus- or adenovirus-mediated transfection of various sPLA2s into BEAS-2B or normal human pulmonary fibroblast cells revealed that group V and X sPLA2s increased arachidonate release and prostaglandin production in both cell types, whereas group IIA and IID sPLA2s failed to do so. Immunohistochemistry of human lungs with pneumonia demonstrated that group V and X sPLA2s were widely expressed in the airway epithelium, interstitium and alveolar macrophages, in which group IID sPLA2 was also positive, whereas group IIA sPLA2 was restricted to the pulmonary arterial smooth muscle layers and bronchial chondrocytes, and group IIE and IIF sPLA2s were minimally detected. These results suggest that group V and X sPLA2s affect lung pathogenesis by facilitating arachidonate metabolism or possibly through other functions.

scholarly journals HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

2000 ◽  
Vol 41 (11) ◽  
pp. 1849-1857 ◽  
Author(s):  
Frederick C. de Beer ◽  
Patrice M. Connell ◽  
J. Yu ◽  
Maria C. de Beer ◽  
Nancy R. Webb ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Scavenger Receptor ◽  
Type I ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Scavenger Receptor Class ◽  
Class B

Association between serum secretory phospholipase A2 and risk of ischemic stroke

2021 ◽  
Author(s):  
Jed W. Smith ◽  
Raphae S. Barlas ◽  
Mamas A. Mamas ◽  
S. Matthijs Boekholdt ◽  
Ziad Mallat ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase
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