In vitro comparison of two changeover methods for vasoactive drug infusion pumps: quick-change versus automated relay

2015 ◽  
Vol 60 (4) ◽  
Author(s):  
Stéphanie Genay ◽  
Bertrand Décaudin ◽  
Sébastien Lédé ◽  
Frédéric Feutry ◽  
Christine Barthélémy ◽  
...  
Keyword(s):  
Vasoactive Drug ◽  
Drug Infusion ◽  
Infusion Pumps ◽  
In Vitro Comparison

AbstractThis study aimed to compare

scholarly journals Changeovers of vasoactive drug infusion pumps: impact of a quality improvement program

Critical Care ◽  
2007 ◽  
Vol 11 (6) ◽  
pp. R133 ◽  
Author(s):  
Laurent Argaud ◽  
Martin Cour ◽  
Olivier Martin ◽  
Marc Saint-Denis ◽  
Tristan Ferry ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Quality Improvement Program ◽  
Vasoactive Drug ◽  
Drug Infusion ◽  
Improvement Program ◽  
Infusion Pumps

Development and in vitro evaluation of a flow-adjustable elastic drug infusion pump

2011 ◽  
Vol 225 (11) ◽  
pp. 1070-1077 ◽  
Author(s):  
S-W Choi ◽  
S-M Kang ◽  
H-Y Kim ◽  
K-W Nam
Keyword(s):  
Flow Pattern ◽  
Infusion Pump ◽  
Injection Rate ◽  
Chamber Pressure ◽  
Elastic Membrane ◽  
Physiological Status ◽  
Drug Infusion ◽  
Short Term ◽  
Infusion Pumps

Passive-type drug infusion pumps have several advantages over active-type pumps including a simple drug chamber structure and relatively high operational stability. However, conventional passive-type infusion pumps also have several limitations compared to active ejection pumps, such as a fixed flowrate and monotonic flow pattern. To enhance the clinical feasibility of using passive-type drug infusion pumps, flow readjustment and flow regulation abilities are needed. This paper proposes a new portable elastic drug infusion pump that integrates the advantages of active and passive infusion pumps to improve clinical feasibility. The proposed infusion pump incorporates a passively driven drug chamber and an actively adjusted flow controller, which can adjust and regulate various target flowrates and adjust the flow pattern in accordance with the patient’s time-varying physiological status. The proposed infusion pump uses the contraction force of an expanded elastic membrane to extract the drug from the drug chamber for delivery into the patient’s body through an outlet catheter. It also utilizes a flow sensor, a flow resistor, and a motor-driven flow restrictor that can monitor the real-time flowrate through the outlet catheter and automatically regulate the actual flowrate around the target value. Experiments on the proposed system resulted in actual injection rates of 0.49 ± 0.03 (mean ± standard deviation), 0.98 ± 0.03, 1.49 ± 0.04, and 1.99 ± 0.03 ml/h when the target injection rate was set to 0.5, 1.0, 1.5, and 2.0 ml/h, respectively. During the entire period of operation from the fully filled state to the totally empty state, an inner-chamber pressure of >100 mmHg was maintained, which shows that the proposed infusion pump can stably maintain its target flowrate as the amount of drug remaining to be injected decreases. It appears that the proposed drug infusion pump can be applied to a wide variety of patient treatments that require short-term, accurate, and stable drug delivery.

scholarly journals Benefits of smart pumps for automated changeovers of vasoactive drug infusion pumps: a quasi-experimental study

2013 ◽  
Vol 111 (5) ◽  
pp. 818-824 ◽  
Author(s):  
M. Cour ◽  
R. Hernu ◽  
T. Bénet ◽  
J.M. Robert ◽  
D. Regad ◽  
...  
Keyword(s):  
Experimental Study ◽  
Vasoactive Drug ◽  
Drug Infusion ◽  
Infusion Pumps ◽  
Quasi Experimental ◽  
Smart Pumps

scholarly journals An in vitro comparison of tibial tray cementation using gun pressurization or pulsed lavage

2014 ◽  
Vol 38 (5) ◽  
pp. 967-971 ◽  
Author(s):  
Ulf J. Schlegel ◽  
Klaus Püschel ◽  
Michael M. Morlock ◽  
Katrin Nagel
Keyword(s):  
Tibial Tray ◽  
Pulsed Lavage ◽  
In Vitro Comparison

scholarly journals A “Smart” Biosensor-Enabled Intravascular Catheter and Platform for Dynamic Delivery of Propofol to “Close the Loop” for Total Intravenous Anesthesia

2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 370-377
Author(s):  
Edward Chaum ◽  
Ernő Lindner
Keyword(s):  
Real Time ◽  
Drug Distribution ◽  
Population Based ◽  
Pharmacokinetic Data ◽  
Drug Infusion ◽  
Blood Concentrations ◽  
The Usa ◽  
The Difference ◽  
Automated Delivery

ABSTRACT Background Target-controlled infusion anesthesia is used worldwide to provide user-defined, stable, blood concentrations of propofol for sedation and anesthesia. The drug infusion is controlled by a microprocessor that uses population-based pharmacokinetic data and patient biometrics to estimate the required infusion rate to replace losses from the blood compartment due to drug distribution and metabolism. The objective of the research was to develop and validate a method to detect and quantify propofol levels in the blood, to improve the safety of propofol use, and to demonstrate a pathway for regulatory approval for its use in the USA. Methods We conceptualized and prototyped a novel “smart” biosensor-enabled intravenous catheter capable of quantifying propofol at physiologic levels in the blood, in real time. The clinical embodiment of the platform is comprised of a “smart” biosensor-enabled catheter prototype, a signal generation/detection readout display, and a driving electronics software. The biosensor was validated in vitro using a variety of electrochemical methods in both static and flow systems with biofluids, including blood. Results We present data demonstrating the experimental detection and quantification of propofol at sub-micromolar concentrations using this biosensor and method. Detection of the drug is rapid and stable with negligible biofouling due to the sensor coating. It shows a linear correlation with mass spectroscopy methods. An intuitive graphical user interface was developed to: (1) detect and quantify the propofol sensor signal, (2) determine the difference between targeted and actual propofol concentration, (3) communicate the variance in real time, and (4) use the output of the controller to drive drug delivery from an in-line syringe pump. The automated delivery and maintenance of propofol levels was demonstrated in a modeled benchtop “patient” applying the known pharmacokinetics of the drug using published algorithms. Conclusions We present a proof-of-concept and in vitro validation of accurate electrochemical quantification of propofol directly from the blood and the design and prototyping of a “smart,” indwelling, biosensor-enabled catheter and demonstrate feedback hardware and software architecture permitting accurate measurement of propofol in blood in real time. The controller platform is shown to permit autonomous, “closed-loop” delivery of the drug and maintenance of user-defined propofol levels in a dynamic flow model.

In vitro comparison of harvesting site effects on cardiac extracellular matrix hydrogels

2021 ◽  
Author(s):  
Emily Mulvany ◽  
Sara McMahan ◽  
Jiazhu Xu ◽  
Narges Yazdani ◽  
Rebecca Willits ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Site Effects ◽  
In Vitro Comparison
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