Detection and distribution of superparamagnetic nanoparticles in lymphatic tissue in a breast cancer model for magnetic particle imaging

2012 ◽  
Vol 57 (SI-1 Track-M) ◽  
Author(s):  
D. Finas ◽  
K. Baumann ◽  
L. Sydow ◽  
K. Heinrich ◽  
K. Gräfe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Particle ◽  
Superparamagnetic Nanoparticles ◽  
Lymphatic Tissue ◽  
Cancer Model ◽  
Magnetic Particle Imaging ◽  
Breast Cancer Model ◽  
Particle Imaging

scholarly journals Applications of PDEs inpainting to magnetic particle imaging and corneal topography

2019 ◽  
Vol 39 (4) ◽  
pp. 453-482 ◽  
Author(s):  
Andrea Andrisani ◽  
Rosa Maria Mininni ◽  
Francesca Mazzia ◽  
Giuseppina Settanni ◽  
Alessandro Iurino ◽  
...  
Keyword(s):  
Fourth Order ◽  
Magnetic Particle ◽  
Approximation Error ◽  
Medical Application ◽  
Superparamagnetic Nanoparticles ◽  
Corneal Surface ◽  
Radial Curvature ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Standard Approximation

In this work we propose a novel application of Partial Differential Equations (PDEs) inpainting techniques to two medical contexts. The first one concerning recovering of concentration maps for superparamagnetic nanoparticles, used as tracers in the framework of Magnetic Particle Imaging. The analysis is carried out by two set of simulations, with and without adding a source of noise, to show that the inpainted images preserve the main properties of the original ones. The second medical application is related to recovering data of corneal elevation maps in ophthalmology. A new procedure consisting in applying the PDEs inpainting techniques to the radial curvature image is proposed. The images of the anterior corneal surface are properly recovered to obtain an approximation error of the required precision. We compare inpainting methods based on second, third and fourth-order PDEs with standard approximation and interpolation techniques.

Sensitive and Specific Detection of Breast Cancer Lymph Node Metastasis Through Dual-Modality Magnetic Particle Imaging and Fluorescence Molecular Imaging: a Preclinical Evaluation

2021 ◽  
Author(s):  
Guorong Wang ◽  
Guangyuan Shi ◽  
Yu Tian ◽  
Lingyan Kong ◽  
Ning Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Magnetic Particle ◽  
Cancer Targeting ◽  
Node Metastasis ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Fluorescence Molecular Imaging ◽  
Biosafety Evaluation

Abstract Purpose: A sensitive and specific imaging method to detect metastatic cancer cells in lymph nodes (LNs) to detect the early-stage breast cancer is urgently needed. The purpose of this study was to investigate a novel breast cancer-targeting and tumour microenvironment ATP-responsive superparamagnetic iron oxide (SPIOs) imaging probe that was developed to detect lymph node metastasis (LNMs) through fluorescence molecular imaging (FMI) and magnetic particle imaging (MPI). The imaging nanoprobe comprised of SPIOs conjugated with breast cancer-targeting peptides (CREKA) and an ATP-responsive DNA aptamer (dsDNA-Cy5.5), abbreviated as SPIOs@A-T. Methods: SPIOs@A-T was synthesised and characterized for its imaging properties, targeting ability and toxicity in vitro. Mice with metastatic lymph node (MLN) of breast cancer were established to evaluate the FMI and MPI imaging strategy in vivo. Healthy mice with normal lymph node (NLN) were used as control group. Histological examination and biosafety evaluation were performed for further assessment. Results: After injection with SPIO@A-T, the obvious high fluorescent intensity and MPI signal were observed in MLN group than those in NLN group. MPI could also complement the limitation of imaging depth from FMI, thus could detect MLN more sensitively. The combination of the imaging strengths of FMI and MPI ensured the detection of breast cancer metastases with high sensitivity and specificity, thereby facilitating the precision differentiation of malignant from benign LNs. Besides, the biosafety evaluation results showed SPIO@A-T had good biocompatibility. Conclusion: Due to the superior properties of tumour-targeting, detection specificity, and biosafety, the SPIOs@A-T imaging probe in combination with FMI and MPI can provide a promising novel method for the early and precise detection of LNMs in clinical practice.

Hydrodynamic and magnetic fractionation of superparamagnetic nanoparticles for magnetic particle imaging

2015 ◽  
Vol 380 ◽  
pp. 266-270 ◽  
Author(s):  
Norbert Löwa ◽  
Patrick Knappe ◽  
Frank Wiekhorst ◽  
Dietmar Eberbeck ◽  
Andreas F. Thünemann ◽  
...  
Keyword(s):  
Magnetic Particle ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Magnetic Fractionation
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