Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease

2011 ◽  
Vol 392 (12) ◽  
pp. 1167-1172 ◽  
Author(s):  
Anne-Kathrin Raab ◽  
Klaus Mönkemüller ◽  
Arne Kandulski ◽  
Ekkehard Weber ◽  
Peter Malfertheiner ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Expression Pattern ◽  
Immune Cells ◽  
Reflux Disease ◽  
Peripheral Blood ◽  
Transcript Levels ◽  
Gastric Biopsies ◽  
Peripheral Immune Cells ◽  
Cathepsin W

Abstract Cathepsin W is exclusively expressed in immune cells, and a novel isoform was identified previously. To characterize the expression pattern of the wildtype and isoform Ins10, specific polymerase chain reaction assays were generated and used to study respective transcript levels in peripheral blood cells and gastric biopsies in healthy subjects. The wildtype-encoding transcript levels were 3- and 9-fold higher in mucosal samples and peripheral immune cells, respectively (p<0.05). The predominant expression of wildtype form by infiltrating immune cells was confirmed in 116 patients with gastroesophageal reflux disease and 27 reflux-negative individuals demonstrating that cathepsin W expression is not altered in this disease.

Expression pattern of cathepsinW-isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease

2011 ◽  
pp. ---
Author(s):  
Anne-Kathrin Raab, ◽  
Klaus Mönkemüller, ◽  
Arne Kandulski, ◽  
Ekkehard Weber, ◽  
Peter Malfertheiner, ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Expression Pattern ◽  
Reflux Disease ◽  
Peripheral Blood

Gastroesophageal Reflux Disease: A Gastroenterologist's Perspective

2011 ◽  
Vol 21 (3) ◽  
pp. 89-99
Author(s):  
Michael F. Vaezi
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Best Practice ◽  
Clinical Care ◽  
Diagnostic Testing ◽  
Diagnostic Tools ◽  
Swallowing Function ◽  
Atypical Symptoms

Gastroesophageal reflux disease (GERD) is a commonly diagnosed condition often associated with the typical symptoms of heartburn and regurgitation, although it may present with atypical symptoms such as chest pain, hoarseness, chronic cough, and asthma. In most cases, the patient's reduced quality of life drives clinical care and diagnostic testing. Because of its widespread impact on voice and swallowing function as well as its social implications, it is important that speech-language pathologists (SLPs) understand the nature of GERD and its consequences. The purpose of this article is to summarize the nature of GERD and GERD-related complications such as GERD-related peptic stricture, Barrett's esophagus and adenocarcinoma, and laryngeal manifestations of GERD from a gastroenterologist's perspective. It is critical that SLPs who work with a multidisciplinary team understand terminology, diagnostic tools, and treatment to ensure best practice.

Laparoscopic antireflux surgery with routine hiatoplasty in the treatment of gastroesophageal reflux disease

2001 ◽  
Vol 120 (5) ◽  
pp. A480-A480
Author(s):  
F GRANDERATH ◽  
U SCHWEIGER ◽  
T KAMOLZ ◽  
T BAMMER ◽  
M PASIUT ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Antireflux Surgery ◽  
Laparoscopic Antireflux Surgery

One-week esomeprazole treatment; An effective contimatory test in patients with suspected gastroesophageal reflux disease

2001 ◽  
Vol 120 (5) ◽  
pp. A426-A426 ◽  
Author(s):  
F JOHNSSON ◽  
J HATTEBACK ◽  
A KLINTENBERG ◽  
J ROMAN ◽  
E TOOTH ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease
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