Epstein-Barr virus lytic cycle activation alters proteasome subunit expression in Burkitt's lymphoma cells

2010 ◽  
Vol 391 (9) ◽  
Author(s):  
Alessandra De Leo ◽  
Giulia Matusali ◽  
Giuseppe Arena ◽  
Livia Di Renzo ◽  
Elena Mattia
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Lytic Cycle ◽  
Host Cells ◽  
Burkitt's Lymphoma ◽  
Lymphoma Cells ◽  
Proteasome Subunit ◽  
Barr Virus ◽  
Subunit Expression ◽  
Epstein Barr

AbstractWe have shown that Epstein-Barr virus (EBV) lytic cycle activation in Burkitt's lymphoma (BL) cells down-regulates chymotrypsin- and caspase-like activities of the proteasome. The aim of the present study was to evaluate whether EBV activation might also affect proteasome subunit composition. Our results indicate that, independently of the latency program established in the host cells, induction of the EBV lytic cycle reduces the expression of the proteasomal components β5, β1 and β2i, whereas it increases that of β2, β1i, PA28α and PA28β. The modulation of the composition and enzymatic activities of the proteolytic complex are indicative of a less efficient generation of viral immunoepitopes.

Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt’s lymphoma cells by affecting multiple molecular targets

2012 ◽  
Vol 96 (2) ◽  
pp. 196-202 ◽  
Author(s):  
Alessandra De Leo ◽  
Giuseppe Arena ◽  
Egidio Lacanna ◽  
Giorgio Oliviero ◽  
Francesca Colavita ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Molecular Targets ◽  
Burkitt’S Lymphoma ◽  
Lytic Cycle ◽  
Burkitt's Lymphoma ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Burkitt’S Lymphoma Cells

scholarly journals IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt’s lymphoma cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186614 ◽  
Author(s):  
Marc Jordi ◽  
Jeannine Marty ◽  
Vanessa Mordasini ◽  
Anna Lünemann ◽  
Scott McComb ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Burkitt’S Lymphoma Cells

scholarly journals Replacement of the Epstein-Barr Virus Plasmid with the EBER Plasmid in Burkitt's Lymphoma Cells

2001 ◽  
Vol 75 (20) ◽  
pp. 9977-9982 ◽  
Author(s):  
Seiji Maruo ◽  
Asuka Nanbo ◽  
Kenzo Takada
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Substantial Decrease ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Do So ◽  
Burkitt’S Lymphoma Cells

ABSTRACT Transfection of an Epstein-Barr virus (EBV)-encoded plasmid containing EBER caused a substantial decrease in the level of plasmid containing EBV in Akata and Mutu Burkitt's lymphoma (BL) lines, but failed to do so in other BL lines. The results suggest that EBER could replace the role of EBV, but other EBV products also play a role in the growth of BL.

scholarly journals Analysis of Apoptosis Morphology in Epstein-Barr Virus Positive and Negative Burkitt's Lymphoma Cells.

1997 ◽  
Vol 60 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Hideaki ISHII ◽  
Glenda C. GOBÉ ◽  
Takashi JOSHITA ◽  
Yoshiyuki KURABAYASHI ◽  
Yasuo HOSOMURA ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Burkitt's Lymphoma ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Burkitt’S Lymphoma Cells
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