Modulation of longevity-associated genes by estrogens or phytoestrogens

2008 ◽  
Vol 389 (3) ◽  
pp. 273-277 ◽  
Author(s):  
Jose Viña ◽  
Juan Sastre ◽  
Federico V. Pallardó ◽  
Juan Gambini ◽  
Consuelo Borrás
Keyword(s):  
Superoxide Dismutase ◽  
Nuclear Factor Kappa B ◽  
Chemical Properties ◽  
Nuclear Factor ◽  
Antioxidant Protection ◽  
Beneficial Effects ◽  
Pathway Activation ◽  
Map Kinase Pathway ◽  
Kinase Pathway ◽  
Lower Peroxide

Abstract Females live longer than males. We have shown that the higher levels of estrogens in females protect them against aging, by up-regulating the expression of antioxidant, longevity-related genes, such as that of selenium-dependent glutathione peroxidase (GPx) and Mn-superoxide dismutase (Mn-SOD). Both estradiol and genistein (the most abundant phytoestrogen in soybeans) share chemical properties which confer antioxidant features to these compounds. However, the low concentration of estrogens and phytoestrogens make it unlikely that they exhibit significant antioxidant capacity in the organism. Physiological concentrations of estrogens and nutritionally relevant concentrations of genistein activate the MAP kinase pathway. These, in turn, activate the nuclear factor kappa B (NF-κB) signaling pathway. Activation of NF-κB by estrogens subsequently activates the expression of Mn-SOD and GPx, but genistein is only capable of activating Mn-SOD expression. This could be due to the fact that genistein binds preferably to estrogen receptor β. The antioxidant protection is reflected in the lower peroxide levels found in cells treated with estrogens or phytoestrogens when compared with controls. The challenge for the future is to find molecules that have the beneficial effects of estradiol, but without its feminizing effects. Phytoestrogens or phytoestrogen-related molecules may be good candidates to meet this challenge.

Biological and medical value of antioxidant protection system of the human body

2021 ◽  
Vol 90 (1) ◽  
pp. 21-32
Author(s):  
O.M. Kovalyova ◽  
T.M. Pasiieshvili
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant System ◽  
Human Body ◽  
Manganese Superoxide Dismutase ◽  
Glutathione Transferase ◽  
Chemical Properties ◽  
Antioxidant Protection ◽  
Glutathione System ◽  
Radical Oxidation ◽  
Manganese Superoxide

The article is devoted to the antioxidant system of the human body in the context of biological and medical significance. The classification of antioxidants in terms of their physical and chemical properties, bioorganic compounds, biochemical effects, mechanisms of implementation of antioxidant protection is presented. The given processes of extreme radical oxidation and mechanisms of antioxidant defense in physiological and pathological conditions. The characteristics of the components of the glutathione system, namely glutathione and enzymes – glutathione peroxidase, glutathione reductase and glutathione transferase are presented. Much attention is paid to manganese superoxide dismutase, an antiradical defense enzyme, as a fundamental regulator of cell proliferation, a mediator of metabolism and apoptosis. Interpretation of changes in the antioxidant enzyme of mitochondrial origin from a prognostic point of view is interpreted on the basis of the results of clinical observations carried out by scientists in various human diseases. The expediency of determining manganese superoxide dismutase in clinical practice for the diagnostic search for the direction of the pathological process, the timely detection of complications and the appointment of adequate therapy is emphasized. Keywords: antioxidant system, classification, glutathione system, manganese superoxide dismutase.

scholarly journals Dietary supplement of Yunkang 10 green tea and treadmill exercise ameliorate high fat diet induced metabolic syndrome of C57BL/6 J mice

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Yanzhong Zhang ◽  
Mingxing Gu ◽  
Ruru Wang ◽  
Menwan Li ◽  
Daxiang Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Green Tea ◽  
High Fat Diet ◽  
Nuclear Factor Kappa B ◽  
Treadmill Exercise ◽  
Nuclear Factor ◽  
High Fat ◽  
Beneficial Effects ◽  
Nuclear Factor Kappa ◽  
Old Mice

Abstract Background Diet and exercise play important roles in ameliorating metabolic syndrome. Yunkang 10 (Camellia sinensis var. assamica) is a most cultivated tea variety for making tea in the Southwestern China. Currently, there is no report of healthy effects of Yunkang 10 green tea (YKGT) and treadmill exercise (Ex) on high fat diet induced metabolic syndrome (MetS). We aimed to investigate the beneficial effects and molecular mechanism of YKGT and Ex using high fat diet induced MetS of C57BL/6 mice. Methods Catechins and caffeine in water extract of YKGT were measured via high performance liquid chromatography (HPLC). 10-week old mice were fed with high fat diet (HFD) for 10 weeks to induce obese mice. Then the obese mice were fed with continuous high fat diet (HFD), HFD with YKGT, HFD with Ex, and HFD with both YKGT and Ex for 8 weeks, respectively. The another group of 10-week old mice fed with low fat diet (LFD) were used as control. Results HPLC data revealed that YKGT has abundantly high concentration of epigallocatechin gallate (EGCG) and caffeine compared to Longjing 43 (Camellia sinensis var. sinensis) green tea. YKGT and Ex significantly decreased the level of blood glucose, serum total cholesterol (TC), triglyceride (TG), insulin, and alanine aminotransferase activity (ALT) when compared to HFD group. The fatty liver and hepatic pro-inflammatory gene expression in the YKGT, Ex and YKGT+Ex groups was mitigated significantly compared with HFD group, respectively. The phosphorylation of inhibitor of nuclear factor kappa-B kinase α/β (IKKα/β) and inhibitor of nuclear factor kappa-B α (IkBα) protein in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathway was also decreased in YKGT or YKGT+Ex groups. The combination of YKGT and Ex prevented gene expression for lipid synthesis in the liver tissue, and significantly upregulated mRNA level of glucose transport genes in the skeletal muscles, when compared to the HFD group. Conclusions This study demonstrated that YKGT supplement or exercise appeared to reverse preexisting metabolic syndrome, and effectively relieved the fatty liver and hepatic inflammatory response induced by high fat diet. YKGT supplement and treadmill exercise together had better beneficial effects than only one intervention.

Abstract LB-118: Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

2019 ◽  
Author(s):  
Emiliano Cocco ◽  
Amanda Kulick ◽  
Sandra Misale ◽  
Rona Yaeger ◽  
Pedram Razavi ◽  
...  
Keyword(s):  
Map Kinase ◽  
Pathway Activation ◽  
Map Kinase Pathway ◽  
Kinase Pathway

scholarly journals MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Feng Wang ◽  
Mingyuan Hu ◽  
Hangju Zhu ◽  
Chao Yang ◽  
Hui Xia ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Protein Expression ◽  
Metabolic Disorders ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Protective Effects ◽  
High Fat ◽  
Beneficial Effects ◽  
Nuclear Factor Kappa ◽  
Mrna And Protein Expression

Abstract Background The beneficial effects of ω−3 polyunsaturated fatty acids (PUFA) vary between different sources. However, there is a paucity of comparative studies regarding the effects and mechanisms of marine and plant ω−3 PUFA on obesity. Objective The aim of this study was to evaluate the effects of fish oil (FO) and perilla oil (PO) on glucolipid metabolism, inflammation, and adipokine in mice fed a high-fat (HF) diet in association with the contribution of toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88) pathway. Methods C57BL/6J mice and MyD88−/− mice were randomly divided into 4 groups: normal chow diet, HF diet, HF diet accompanied by daily gavage with either FO or PO. After 4 weeks, blood biochemistries, adipocyte histology, mRNA, and protein expression of MyD88-dependent and -independent pathways of TLR4 signaling in epididymal adipose tissue were measured. Results In C57BL/6J mice, there were no statistical differences between FO and PO in decreasing body weight, glucose, insulin, triglyceride, total cholesterol, interleukin-6, and increasing adipocyte counts. FO and PO decreased mRNA and protein expression of TLR4, MyD88, tumor necrosis factor receptor-associated factor 6, inhibitor of nuclear factor kappa B kinase beta and nuclear factor-kappa B p65. In MyD88−/− mice, the beneficial effects of FO and PO on HF diet-induced metabolism abnormalities and inflammation were abolished. FO and PO had no impacts on mRNA and protein expression of receptor-interacting protein-1, interferon regulate factor 3, and nuclear factor-kappa B p65. Conclusion FO and PO exhibit similar protective effects on metabolic disorders and inflammation through inhibiting TLR4 signaling in a manner dependent on MyD88. These findings highlight plant ω−3 PUFA as an attractive alternative source of marine ω−3 PUFA and reveal a mechanistic insight for preventive benefits of ω−3 PUFA in obesity and related metabolic diseases.

scholarly journals CD105 (Endoglin): A Potential Anticancer Therapeutic Inhibits Mitogenesis and Map Kinase Pathway Activation

2021 ◽  
Vol 41 (3) ◽  
pp. 1219-1229
Author(s):  
DONGHUI LIU ◽  
SHANT KUMAR ◽  
JASON ASHWORTH ◽  
KAMELA ALI ◽  
ABDULMANNAN FADEL ◽  
...  
Keyword(s):  
Map Kinase ◽  
Pathway Activation ◽  
Map Kinase Pathway ◽  
Kinase Pathway

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 ◽  
Vol 15 (6) ◽  
pp. 1292-1300 ◽  
Author(s):  
A. Migliaccio ◽  
M. Di Domenico ◽  
G. Castoria ◽  
A. de Falco ◽  
P. Bontempo ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Map Kinase ◽  
Receptor Complex ◽  
Estradiol Receptor ◽  
Pathway Activation ◽  
Map Kinase Pathway ◽  
Kinase Pathway ◽  
Mcf 7

Analysis of dependence of antidepressant properties of TrkB receptor ligands on MAP-kinase pathway activation

2015 ◽  
Vol 460 (1) ◽  
pp. 20-22 ◽  
Author(s):  
T. A. Gudasheva ◽  
I. O. Logvinov ◽  
P. Yu. Povarnina ◽  
T. A. Antipova ◽  
S. B. Seredenin
Keyword(s):  
Map Kinase ◽  
Receptor Ligands ◽  
Trkb Receptor ◽  
Pathway Activation ◽  
Map Kinase Pathway ◽  
Kinase Pathway
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