Self-organization versus Watchmaker: stochastic dynamics of cellular organization

2005 ◽  
Vol 386 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Alexei Kurakin
Keyword(s):  
Experimental Evidence ◽  
Stochastic Dynamics ◽  
Molecular System ◽  
Living Cells ◽  
Integrated System ◽  
Self Organization ◽  
Cellular Organization ◽  
Time Dynamics ◽  
Design Charts ◽  
Growing Body

AbstractThe cell, as a molecular system, is often interpreted in terms of complex clockworks, and the design charts of mechanical and electrical engineering are assumed to provide adequate approximations for the description of cellular organization. However, a growing body of experimental evidence obtained through the observation and analysis of real-time dynamics of fluorescently labeled molecules inside living cells is increasingly inconsistent with the classico-mechanistic perception of the cell. An overview of recent studies favors an emerging alternative image of the cell as a dynamic integrated system of interconnected and interdependent metastable molecular organizations realized through stochasticity and self-organization.

scholarly journals Physiological levels of TNF  stimulation induce stochastic dynamics of NF- B responses in single living cells

2010 ◽  
Vol 123 (16) ◽  
pp. 2834-2843 ◽  
Author(s):  
D. A. Turner ◽  
P. Paszek ◽  
D. J. Woodcock ◽  
D. E. Nelson ◽  
C. A. Horton ◽  
...  
Keyword(s):  
Stochastic Dynamics ◽  
Living Cells ◽  
Single Living Cells ◽  
Single Living

Nesprin isoforms: are they inside or outside the nucleus?

2010 ◽  
Vol 38 (1) ◽  
pp. 278-280 ◽  
Author(s):  
Glenn E. Morris ◽  
K. Natalie Randles
Keyword(s):  
Membrane Proteins ◽  
Experimental Evidence ◽  
Nuclear Membrane ◽  
Nuclear Import ◽  
Nuclear Lamina ◽  
Cellular Organization ◽  
Inner Nuclear Membrane

The giant isoforms of nesprins 1 and 2 are emerging as important players in cellular organization, particularly in the positioning of nuclei, and possibly other organelles, within the cytoplasm. The experimental evidence suggests that nesprins also occur at the inner nuclear membrane, where they interact with the nuclear lamina. In this paper, we consider whether this is consistent with current ideas about nesprin anchorage and about mechanisms for nuclear import of membrane proteins.

scholarly journals A live-cell marker to visualize the dynamics of stable microtubules

2021 ◽  
Author(s):  
Klara I Jansen ◽  
Mithila Burute ◽  
Lukas C Kapitein
Keyword(s):  
Cell Division ◽  
Intracellular Transport ◽  
Living Cells ◽  
Live Cell ◽  
Organelle Transport ◽  
Cellular Organization ◽  
Cell Marker ◽  
Post Translational Modifications ◽  
And Function

The microtubule (MT) cytoskeleton underlies processes such as intracellular transport and cell division. Immunolabeling for post-translational modifications of tubulin has revealed the presence of different MT subsets, which are believed to differ in stability and function. Whereas dynamic MTs can readily be studied using live-cell plus-end markers, the dynamics of stable MTs have remained obscure due to a lack of tools to directly visualize these MTs in living cells. Here, we present a live-cell marker to visualize stable MTs and explore their dynamics. We demonstrate that a rigor mutant of kinesin-1 binds selectively to acetylated MTs without affecting MT organization and organelle transport. These MTs are long-lived, do not depolymerize upon nocadozale-treatment or laser-based severing, and display rich dynamics, including undulation, looping and sliding. This marker will help to explore how different MT subsets contribute to cellular organization and transport.

The Buzz on the Queen Bee and Other Characterizations of Women’s Intrasexual Competition at Work

2016 ◽  
Author(s):  
Lucie Kocum ◽  
Delphine S. Courvoisier ◽  
Saundra Vernon
Keyword(s):  
Social Identity ◽  
Experimental Evidence ◽  
Working Life ◽  
Intrasexual Competition ◽  
Negative Consequences ◽  
Women In The Workplace ◽  
Growing Body ◽  
Similarities And Differences ◽  
Prejudice And Discrimination ◽  
Zero Sum

Competition is a normal part of working life. It is expected of both women and men as they enter the workforce, and as they ascend the corporate ladder. Interestingly, women are often vilified for engaging in competition, particularly with members of their own sex. The focus of this essay is intrasexual competition among women in the workplace. It provides a description of workplace competition and its positive and negative consequences for workers and organizations, followed by similarities and differences in women’s and men’s competitive experiences and styles. The ways zero-sum contexts such as tokenism affect social identity and give rise to the intrasexual prejudice and discrimination—most notably, the queen bee—are discussed. The essay ends with a discussion based on the authors’ experimental evidence of intragroup favoritism among women, and a growing body of work underscoring the importance of not expecting women to be allies without accompanying organizational change.

scholarly journals Modelling based in the stochastic dynamics for the time evolution of the COVID-19

2020 ◽  
Author(s):  
Leonardo dos Santos Lima
Keyword(s):  
Differential Equation ◽  
Evolution Equation ◽  
Stochastic Model ◽  
Stochastic Differential Equation ◽  
Stochastic Dynamics ◽  
Planck Equation ◽  
Time Dynamics ◽  
Health Agencies ◽  
System Of Particles ◽  
Effective Description

Abstract The stochastic differential equation (SDE) corresponding to nonlinear Fokker-Planck equation where the nonlinearity appearing in this evolution equation can be interpreted as providing an effective description of a system of particles interacting is obtained. Additionally, we propose a stochastic model for time dynamics of the COVID-19 based in the set of data supported by the Brazilian health agencies.

Biochemical topology: From vectorial metabolism to morphogenesis

1991 ◽  
Vol 11 (6) ◽  
pp. 347-385 ◽  
Author(s):  
Franklin M. Harold
Keyword(s):  
Living Cells ◽  
Energy Transduction ◽  
Self Organization ◽  
Cellular Space ◽  
Biochemical Processes ◽  
Cellular Physiology ◽  
Cytoplasmic Transport ◽  
Fungal Hyphae ◽  
Vectorial Metabolism ◽  
Point Of Departure

In living cells, many biochemical processes are spatially organized: they have a location, and often a direction, in cellular space. In the hands of Peter Mitchell and Jennifer Moyle, the chemiosmotic formulation of this principle proved to be the key to understanding biological energy transduction and related aspects of cellular physiology. For H. E. Huxley and A. F. Huxley, it provided the basis for unravelling the mechanism of muscle contraction; and vectorial biochemistry continues to reverberate through research on cytoplasmic transport, motility and organization. The spatial deployment of biochemical processes serves here as a point of departure for an inquiry into morphogenesis and self-organization during the apical growth of fungal hyphae.

From Dynamics to Details: Live-Cell Light Microscopy and Highresolution (25 nm) Soft X-Ray Microscopy

2000 ◽  
Vol 6 (S2) ◽  
pp. 84-85
Author(s):  
C. A. Larabell ◽  
D. Yager ◽  
W. Meyer-Ilse ◽  
B. A. Rowning
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Cell Function ◽  
Living Cells ◽  
Live Cell ◽  
Specimen Preparation ◽  
Cellular Organization ◽  
X Ray ◽  
Structural Details ◽  
Microscopy Techniques

Imaging cells using a variety of microscopy techniques has generated information about the organization of cells and subcellular structures that is the foundation for understanding cell function. Invaluable information about the dynamics of cells has been obtained from a variety of light microscopy techniques, and the exquisite structural details of cellular organization have been obtained from electron microscopy. Each of these approaches, however, has its limitations. The resolution provided by light microscopy is limited by the wavelength of light, whereas the specimen preparation required for examining cells using electron microscopy is extremely tedious and time consuming. We show that soft x-ray microscopy can bridge the gap between these two forms of microscopy by providing a method for examining whole, hydrated cells up to 10 um thick at 25 nm resolution. Examination of rapidly frozen cells provides information that closely approximates that seen in living cells.

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