PLASMA AND ERYTHROCYTE SELENIUM (Se), GLUTATHIONE PEROXYDASE (GSH-Px), MALONDIALDEHYDE (MDA) AND PLASMA LIPID HYDROPEROXIDES (LH) AS A FUNCTION OF Se SUPPLEMENTATION IN 12 TREATED PHENYLKETONURIC (PKU) CHILDREN

1988 ◽  
pp. 337-340 ◽  
Author(s):  
B. Wilke ◽  
M. Vidailhet ◽  
C. Guillemin ◽  
A. Favier ◽  
V. Ducros ◽  
...  
Keyword(s):  
Plasma Lipid ◽  
Lipid Hydroperoxides

scholarly journals Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Kazunobu Ishikawa ◽  
Mohamad Navab ◽  
Aldons J. Lusis
Keyword(s):  
Heme Oxygenase ◽  
Knockout Mice ◽  
Plasma Lipid ◽  
Heme Oxygenase 1 ◽  
Chow Diet ◽  
Lipid Hydroperoxides ◽  
Standard Chow Diet ◽  
Lower Body Weight ◽  
One Year ◽  
Plasma Lipid Peroxidation

To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice. Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak formation even on a standard chow diet. Levels of plasma total cholesterol and HDL were similar among the three genotypes. However, homozygous HO-1-knockout mice had lower body weight and plasma triglyceride. HO-1-deficiency resulted in alteration of the composition of HDL. The ratio of apolipoprotein AI to AII in HO-1-knockout mice was reduced about 10-fold as compared to wild-type mice. In addition, paraoxonase, an enzyme against oxidative stress, was reduced less than 50% in HO-1-knockout mice. The knockout mice also exhibited significant elevation of plasma lipid hydroperoxides. This study using aged HO-1-knockout mice strengthened the idea that HO-1 functions to suppress systemic inflammation in artery wall and prevents plasma lipid peroxidation.

Elevated plasma lipid hydroperoxides in patients with coronary artery disease

1997 ◽  
Vol 134 (3) ◽  
pp. 572-576 ◽  
Author(s):  
Iren B. Kovacs ◽  
Marjan Jahangiri ◽  
Gareth M. Rees ◽  
Peter Görög
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Lipid ◽  
Lipid Hydroperoxides ◽  
Elevated Plasma ◽  
Artery Disease

scholarly journals Values of plasma lipid hydroperoxides and total antioxidant status in healthy dairy cows: preliminary observations

2003 ◽  
Vol 46 (3) ◽  
pp. 227-233 ◽  
Author(s):  
C. Castillo ◽  
J. Hernández ◽  
M. López-Alonso ◽  
M. Miranda ◽  
J. Luís
Keyword(s):  
Dairy Cows ◽  
Milk Yield ◽  
Antioxidant Status ◽  
Clinical Medicine ◽  
Plasma Lipid ◽  
Total Antioxidant Status ◽  
Metabolic Parameters ◽  
Lipid Hydroperoxides ◽  
Free Radical Damage ◽  
Total Antioxidant

Abstract. Metabolic parameters have been used in an attempt to monitor the health, reproductive and nutritional status of dairy cows. Nevertheless, in the last few years the detection of free radical damage, and the protection against it has become very important in the practice of clinical medicine. This report aims to establish values for plasma lipid hydroperoxides (LOOH) and total antioxidant status (TAS) in healthy cows and its relationship with milk yield. The study was carried out with 22 healthy dairy cows divided into two groups: animals with a low production rate and animals with a high milk yield. Results showed that the animals with a high milk yield present higher LOOH levels than the other group. This increase in oxidant compounds is not accompanied by higher levels in protective antioxidant substances. LOOH and TAS measurements give complementary information about the metabolic status of the animal than metabolic parameters alone.

scholarly journals Low-density lipoprotein is the major carrier of lipid hydroperoxides in plasma. Relevance to determination of total plasma lipid hydroperoxide concentrations

1996 ◽  
Vol 313 (3) ◽  
pp. 781-786 ◽  
Author(s):  
Jaffar NOUROOZ-ZADEH ◽  
Jarad TAJADDINI-SARMADI ◽  
K. L. Eddie LING ◽  
Simon P. WOLFF
Keyword(s):  
Total Lipid ◽  
Xylenol Orange ◽  
Low Density Lipoprotein ◽  
Lipid Hydroperoxide ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Ldl Oxidation ◽  
Lipid Hydroperoxides ◽  
Very Low Density Lipoprotein ◽  
Low Density

High-density lipoprotein (HDL) has been proposed as the principal carrier of hydroperoxides in plasma, based upon data gathered with an HPLC-chemiluminescence technique. To test this hypothesis we have measured total lipid hydroperoxides in native plasma using the ferrous oxidation in Xylenol Orange (FOX) assay and then fractionated plasma into very-low-density lipoprotein, low-density lipoprotein (LDL) and HDL fractions. Hydroperoxides were found to accumulate principally (more than 65%) in LDL, as judged by hydroperoxide content per amount of protein or cholesterol, or expressed as a proportion of total hydroperoxide in plasma. Plasma was also incubated at 37 °C in the presence and absence of 2,2´-azo-bis-(2-amidinopropane) hydrochloride (AAPH), an azo-initiator of lipid peroxidation. The majority of hydroperoxides generated in plasma were recovered in the LDL fraction. Furthermore, when isolated lipoproteins were subject to oxidation initiated by AAPH, very-low-density lipoprotein and LDL showed the greatest propensity for hydroperoxide accumulation, whereas HDL seemed relatively resistant. Estimates for plasma and LDL peroxidation based upon techniques which measure total lipid hydroperoxides suggest that levels of hydroperoxides in plasma and LDL are far higher than that those estimates generated by ostensibly more selective techniques. Higher levels of hydroperoxides in LDL than those reported by HPLC-chemiluminescence also seem in greater accordance with other available data concerning LDL oxidation.

Vitamin E intake and systemic antioxidant status in competitive endurance horses

2005 ◽  
Vol 2 (3) ◽  
pp. 149-152 ◽  
Author(s):  
CA Williams ◽  
DS Kronfeld ◽  
TM Hess ◽  
KE Saker ◽  
JE Waldron ◽  
...  
Keyword(s):  
Vitamin E ◽  
Antioxidant Status ◽  
Plasma Lipid ◽  
Measured Data ◽  
Lipid Hydroperoxides ◽  
Total Glutathione ◽  
Blood Samples ◽  
Total Diet ◽  
And Performance ◽  
Commercial Feeds

AbstractThe objective was to compare vitamin E content in the total diet of Arabian horses competing in the 80 km Research Ride 2002 to the oxidative stress and antioxidant measures throughout the race. Prior to the race, riders completed a detailed nutritional survey, which was used to calculate vitamin E intake. Blood samples, temperature and heart rate were taken the day before the race, at 27 and 48 km during the race, at race completion or elimination and 3 h after race completion. Plasma lipid hydroperoxides, α-tocopherol (TOC), creatine kinase (CK), aspartate aminotransferase (AST), albumin, red and white blood cell total glutathione and glutathione peroxidase were measured. Data were analyzed by Pearson's correlation in SAS. From the survey, it was estimated that horses consumed 2265±114 IU day−1 of vitamin E. A negative correlation was found between the vitamin E intake and CK (r = −0.23; P = 0.002), and AST (r = −0.22; P = 0.003). A positive correlation was found between the vitamin E intake and plasma TOC (r = 0.15; P = 0.005) at all sample times. This suggests that intensely exercising horses supplemented with vitamin E may not have an improved welfare and performance if they are supplemented vitamin E versus what is naturally found in forages and commercial feeds.

Postprandial Plasma Lipid Hydroperoxides: A Possible Link Between Diet and Atherosclerosis

1998 ◽  
Vol 25 (2) ◽  
pp. 250-252 ◽  
Author(s):  
Fulvio Ursini ◽  
Adriana Zamburlini ◽  
Giuseppe Cazzolato ◽  
Matilde Maiorino ◽  
Gabriele Bittolo Bon ◽  
...  
Keyword(s):  
Plasma Lipid ◽  
Lipid Hydroperoxides

scholarly journals Red wine prevents the postprandial increase in plasma cholesterol oxidation products: a pilot study

2011 ◽  
Vol 105 (12) ◽  
pp. 1718-1723 ◽  
Author(s):  
F. Natella ◽  
A. Macone ◽  
A. Ramberti ◽  
M. Forte ◽  
F. Mattivi ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Red Wine ◽  
Plasma Cholesterol ◽  
Plasma Lipid ◽  
Oxidation Products ◽  
Cholesterol Oxidation ◽  
Lipid Hydroperoxides ◽  
Water Control ◽  
Cholesterol Oxidation Products ◽  
Wine Consumption

Moderate wine consumption has been shown to lower cardiovascular risk. One of the mechanisms could involve the control of postprandial hyperlipaemia, a well-defined risk factor for atherosclerosis, reasonably by reducing the absorption of lipid oxidised species from the meal. The objective of the present study was to investigate whether wine consumption with the meal is able to reduce the postprandial increase in plasma lipid hydroperoxides and cholesterol oxidation products, in human subjects. In two different study sessions, twelve healthy volunteers consumed the same test meal rich in oxidised and oxidisable lipids (a double cheeseburger), with 300 ml of water (control) or with 300 ml of red wine (wine). The postprandial plasma concentration of cholesterol oxidation products was measured by GC–MS. The control meal induced a significant increase in the plasma concentration of lipid hydroperoxides and of two cholesterol oxidation products, 7-β-hydroxycholesterol and 7-ketocholesterol. The postprandial increase in lipid hydroperoxides and cholesterol oxidation products was fully prevented by wine when consumed with the meal. In conclusion, the present study provides evidence that consumption of wine with the meal could prevent the postprandial increase in plasma cholesterol oxidation products.

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