Long term effects of human growth hormone on 1,959 patients with pituitary dwarfism throughout Japan.

1984 ◽  
Vol 31 (2) ◽  
pp. 201-206 ◽  
Author(s):  
KAZUO SHIZUME
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Long Term Effects ◽  
Pituitary Dwarfism

SULPHATION FACTOR ACTIVITY AND GROWTH RATE DURING LONG-TERM TREATMENT OF PATIENTS WITH PITUITARY DWARFISM WITH HUMAN GROWTH HORMONE

1972 ◽  
Vol 69 (3) ◽  
pp. 417-433 ◽  
Author(s):  
Kerstin Hall ◽  
Patrick Olin
Keyword(s):  
Growth Hormone ◽  
Growth Rate ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Term Treatment ◽  
Factor Activity ◽  
Duration Of Treatment ◽  
Pituitary Dwarfism ◽  
Long Term Treatment

ABSTRACT Twenty patients with pituitary dwarfism were treated for nine months to 2½ years with human growth hormone (HGH) prepared according to Roos et al. (1963). Eleven of them had previously been given other HGH preparations for one to five years. During the first two years of treatment with HGH in a dose of 0.2 mg (0.4 IU) and 0.3 mg (0.6 IU) per kg body weight per week, the increase in growth rate was two- to threefold, and three- to fivefold, respectively. Long-termed treatment with HGH was accompanied by a decreasing ability of the hormone to stimulate growth. Cortisone acetate, in replacement doses, had no influence on this growth rate. During the present study only one of the 20 patients developed antibodies to HGH. The levels of sulphation factor (SF) activity in serum were low before treatment and increased significantly during treatment with HGH. There was a linear relationship between the SF activity in the serum and the slope of the growth carves. Both increased with the dose of HGH administered but decreased with duration of treatment.

Long-term effects of human growth hormone-releasing hormone and photoperiod on hormone release and puberty in dairy heifers1

1994 ◽  
Vol 72 (10) ◽  
pp. 2709-2717 ◽  
Author(s):  
H. Ringuet ◽  
G. Pelletier ◽  
P. Brazeau ◽  
P. Gaudreau ◽  
L. A. Guilbault ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Hormone Release ◽  
Growth Hormone Releasing Hormone ◽  
Long Term Effects ◽  
Releasing Hormone

LONG-TERM EFFECTS OF HUMAN GROWTH HORMONE (LI) IN A PITUITARY DWARF*

1961 ◽  
Vol 21 (6) ◽  
pp. 721-726 ◽  
Author(s):  
ROBERTO F. ESCAMILLA ◽  
JOHN J. HUTCHINGS ◽  
WILLIAM C. DEAMER ◽  
CHOH HAO LI ◽  
PETER H. FORSHAM
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Long Term Effects

SERUM LEVELS OF SOMATOMEDIN A AND GROWTH DURING LONG-TERM TREATMENT OF PATIENTS WITH PITUITARY DWARFISM WITH HUMAN GROWTH HORMONE

1979 ◽  
Vol 92 (3) ◽  
pp. 385-397 ◽  
Author(s):  
Kazue Takano ◽  
Naomi Hizuka ◽  
Kazuo Shizume ◽  
Yoko Hasumi
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Bone Age ◽  
Serum Levels ◽  
Term Treatment ◽  
Duration Of Treatment ◽  
Pituitary Dwarfism ◽  
Long Term Treatment

ABSTRACT Eighteen patients with pituitary dwarfism were treated for 1 7/12 to 6 years with human growth hormone (hGH) at a dose of 0.19–0.62 unit (U) per kg of body weight per week. The mean increment in height was 2.0 ± 0.4 and 8.8 ± 0.5 cm/year before and the first year after treatment of hGH, respectively. A significant positive correlation was observed between serum levels of somatomedin A and growth rate, especially in children with bone age below 10 and a duration of treatment of less than one year (r = 0.66, P < 0.005). Long-term treatment with hGH was accompanied by a decreasing response. However, the serum levels of somatomedin A did not decrease significantly. Therefore, decreased growth increment in these situations was not due to decreased serum levels of somatomedin A.

Glucose Metabolism in Ullrich Turner Syndrome: Long-Term Effects of Therapy with Human Growth Hormone

1993 ◽  
Vol 39 (1-2) ◽  
pp. 36-41 ◽  
Author(s):  
M. Weise ◽  
D. James ◽  
C.H. Leitner ◽  
K.K.P. Hartmann ◽  
H.J. B&ouml;hles ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Glucose Metabolism ◽  
Turner Syndrome ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Long Term Effects

scholarly journals Results of Long-Term Human Growth Hormone Therapy for Pituitary Dwarfism

1970 ◽  
Vol 17 (4) ◽  
pp. 297-306 ◽  
Author(s):  
KAZUO SHIZUME ◽  
FUKASHI MATSUZAKI ◽  
MINORU IRIE ◽  
NAKAAKI OSAWA
Keyword(s):  
Growth Hormone ◽  
Hormone Therapy ◽  
Human Growth Hormone ◽  
Growth Hormone Therapy ◽  
Human Growth ◽  
Pituitary Dwarfism
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