scholarly journals EFFECT OF GROWTH HORMONE AND CORTISONE ACETATE UPON MITOTIC ACTIVITY IN NORMAL AND REGENERATING TISSUES OF AMPHIBIA

1956 ◽  
Vol 3 (4) ◽  
pp. 236-241 ◽  
Author(s):  
SAKAE INOUE
Keyword(s):  
Growth Hormone ◽  
Mitotic Activity ◽  
Cortisone Acetate

EFFECTS OF STILBOESTROL ON GROWTH HORMONE SECRETION AND PITUITARY CELL PROLIFERATION IN THE MALE RAT

1971 ◽  
Vol 51 (3) ◽  
pp. 473-481 ◽  
Author(s):  
H. M. LLOYD ◽  
J. D. MEARES ◽  
JOAN JACOBI ◽  
FRANCES J. THOMAS
Keyword(s):  
Growth Hormone ◽  
Cell Proliferation ◽  
Mitotic Activity ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Mean Value ◽  
Pituitary Cell ◽  
Male Rats ◽  
Male Rat ◽  
Serum Growth Hormone

SUMMARY A single 12 mg dose of stilboestrol dipropionate given to 100-day-old male rats resulted in increased pituitary mitotic activity, pituitary weight and serum growth hormone; the latter rose from a mean value of 20 ng/ml to a maximum of 342 ng/ml 9 days later. Serum growth hormone and pituitary mitotic activity then gradually diminished but were still slightly increased on day 28. Serum growth hormone and pituitary weight were significantly correlated during the periods of rapidly rising and of sustained high levels of serum growth hormone. Indices of mitotic activity were correlated with serum growth hormone during the periods of rapidly rising and of falling levels of serum growth hormone.

Acute effects of cortisone acetate on growth hormone response to growth hormone-releasing hormone in normal adult subjects

1990 ◽  
Vol 122 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Andrea Giustina ◽  
Mauro Doga ◽  
Corrado Bodini ◽  
Angela Girelli ◽  
Fabio Legati ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Random Order ◽  
Serum Cortisol ◽  
Cortisone Acetate ◽  
Acute Administration ◽  
Acute Effects ◽  
Gh Secretion ◽  
Normal Man ◽  
The Relationship ◽  
Dose Dependent

Abstract Glucocorticoids have been shown to inhibit GH secretion in normal man when administered in large amounts for several days. The aim of our study was 1. to investigate the acute effects of a single dose of glucocorticoids on GH secretion in normal man; 2. to look at the relationship between the increase in serum cortisol concentration and GH response to the stimuli. Six healthy volunteers received on three occasions in random order an iv injection of GHRH (1–29) NH2, 100 μg, alone or 60 min after oral administration of either 25 or 50 mg of cortisone acetate. Mean stimulated GH levels, GH peak and integrated GH concentration were significantly lower after GHRH plus cortisone 25 mg than after GHRH alone. Mean GH levels at 15 and 30 min after GHRH injection and the peak GH level showed a further decrease after GHRH plus cortisone 50 mg. We conclude that acute administration of pharmacological doses of glucocorticoids is able to inhibit GH response to GHRH, probably through enhancement of endogenous somatostatin release. Moreover, this pharmacological effect of glucocorticoids seems to be dose-dependent and thus directly related to serum cortisol concentrations.

EARLY EFFECTS OF STILBOESTROL ON GROWTH HORMONE AND PROLACTIN SECRETION AND ON PITUITARY MITOTIC ACTIVITY IN THE MALE RAT

1973 ◽  
Vol 58 (2) ◽  
pp. 227-231 ◽  
Author(s):  
H. M. LLOYD ◽  
J. D. MEARES ◽  
JOAN JACOBI
Keyword(s):  
Growth Hormone ◽  
Mitotic Activity ◽  
Single Injection ◽  
Prolactin Secretion ◽  
Male Rats ◽  
Male Rat ◽  
Serum Prolactin ◽  
Serum Growth Hormone ◽  
Total Period ◽  
Early Effects

SUMMARY The effects of a single injection of 1 mg diethylstilboestrol dipropionate on pituitary mitotic activity and on secretion of growth hormone and prolactin were investigated in male rats on each of the first 15 days following the single dose and then at intervals for a total period of 63 days. Mitotic activity increased to a maximum on day 4 and then gradually diminished. Serum growth hormone was moderately increased during the 2nd week and serum prolactin showed a gradual rise with a return to normal on day 63. In the pituitary gland, growth hormone concentration diminished until day 28, whereas prolactin rose quickly at first, maintained a raised level and increased further on day 43. During the first 12 days, pituitary weight was significantly correlated with serum growth hormone and prolactin concentration. During days 13–28, serum prolactin, but not growth hormone, was significantly correlated with the pituitary mitotic index.

scholarly journals Effects of Pituitary and Adrenal Hormones on the Numbers of Thoracic Duct Lymphocytes

Blood ◽  
1952 ◽  
Vol 7 (2) ◽  
pp. 193-206 ◽  
Author(s):  
GERALD F. HUNGERFORD ◽  
WILLIAM O. REINHARDT ◽  
CHOH HAO LI
Keyword(s):  
Growth Hormone ◽  
Adrenal Cortex ◽  
Thoracic Duct ◽  
Anterior Pituitary ◽  
Cortisone Acetate ◽  
Adrenal Hormones ◽  
Peptide Mixture ◽  
Peptide Mixtures ◽  
Hypophysectomized Rats ◽  
Adrenalectomized Rats

Abstract The endocrine influences of hypophysectomy, adrenalectomy, and the administration of pituitary and adrenal hormones on the level of thoracic duct lymphocytes have been studied in test animals under standardized conditions. The following effects have been noted: 1. Numbers of thoracic duct lymphocytes are elevated after either hypophysectomy or adrenalectomy in the rat. 2. After the administration of either ACTH protein or pepsin peptide mixtures to normal or hypophysectomized rats, the number of thoracic duct lymphocytes is significantly reduced. This effect was not noted in adrenalectomized rats. These effects were observed two hours after administration of the ACTH preparations. If a shorter time elapsed, no effect was noted with the ACTH protein, nor was any effect noted with an ACTH acid peptide mixture under the conditions employed. 3. Administration of epinephrine to normal or hypophysectomized rats, singly or in combination with ACTH protein (in which case its effect was potentiated), produced a significant reduction in the number of thoracic duct lymphocytes. This effect was not observed in the adrenalectomized rat, suggesting that epinephrine may act directly in producing this effect. 4. Growth hormone (beef anterior pituitary), Pitressin, Pitocin, Adrenal Cortex Extract, cortisone acetate, and desoxycorticosterone glucoside did not alter the levels of thoracic duct lymphocytes under the conditions of these experiments.

THE EFFECTS OF GROWTH HORMONE AND CORTICOTROPHIN UPON THE ADRENAL WEIGHT AND ADRENOCORTICAL MITOTIC ACTIVITY IN THE HYPOPHYSECTOMIZED RAT

1955 ◽  
Vol 12 (3) ◽  
pp. 174-184 ◽  
Author(s):  
D. B. CATER ◽  
M. P. STACK-DUNNE
Keyword(s):  
Growth Hormone ◽  
Cell Division ◽  
Mitotic Activity ◽  
Great Increase ◽  
Adrenal Weight ◽  
Synergic Effect ◽  
Single Test ◽  
Pituitary Growth Hormone ◽  
Artificial Mixtures ◽  
Stimulation Of

SUMMARY 1. Treatment of rats 17–24 days after hypophysectomy with pituitary growth hormone for 3 days causes a definite, although limited, increase in adrenal weight. When growth hormone and corticotrophin are given simultaneously, the increase in adrenal weight is greater than the sum of the effects with the hormones separately. The larger the dose of corticotrophin the greater the synergic effect. 2. The action of growth hormone on the adrenal is characterized by a striking stimulation of cell division with relatively little effect on adrenal weight. Corticotrophin also stimulates adrenocortical mitotic activity, but to obtain mitotic activity equivalent to that with growth hormone, doses must be given sufficient to cause a great increase in adrenal weight. This is true whether corticotrophin is injected in saline or in a beeswax/arachis oil mixture. 3. The characteristic activity of each preparation in stimulating the adrenal can be expressed in terms of a quotient, Qmw, the ratio of mitosis-stimulating activity to increase of adrenal weight in a single test. This index is effectively independent of the absolute responses. For growth hormone, Qmw is high; for biologically pure corticotrophin, it is low. Artificial mixtures of the two hormones give intermediate values of the quotient; crude corticotrophin preparations give values higher than those for purified preparations.

HGH and Cartilage

2021 ◽  
Author(s):  
Gordon Slater
Keyword(s):  
Growth Hormone ◽  
Mitotic Activity ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Cell Maturation ◽  
Improve Treatment ◽  
Cartilage Differentiation ◽  
And Cartilage ◽  
Proof Of Principle

Recombinant human growth hormone (rHGH) which plays an important role for remodeling of bone has an effect on cartilage differentiation and regeneration, as well. Herein, we reviewed human growth hormone and its roles on cartilage. We discussed different roles on growth, regeneration, inflammation, cell maturation, and mitotic activity. These findings provide proof of principle that therapeutics based on rHGH can improve treatment for numerous disorders.

Sign in / Sign up

Export Citation Format

Share Document