scholarly journals Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma

2011 ◽  
Vol 58 (7) ◽  
pp. 527-534 ◽  
Author(s):  
Ryuji Kouyama ◽  
Kiichiro Hiraishi ◽  
Toru Sugiyama ◽  
Hajime Izumiyama ◽  
Takanobu Yoshimoto ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Adrenocortical Carcinoma ◽  
Clinicopathological Features

COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers

2010 ◽  
Vol 14 (7) ◽  
pp. 655-664 ◽  
Author(s):  
Antonella Miglietta ◽  
Marina Toselli ◽  
Nicoletta Ravarino ◽  
Walter Vencia ◽  
Andrea Chiecchio ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Clinicopathological Features ◽  
Breast Carcinomas ◽  
Human Breast ◽  
Human Breast Carcinomas ◽  
Cox 2

scholarly journals Clinicopathological Features of Pediatric Functional Adrenocortical Carcinoma Diagnosed by Weiss Criteria; An Analysis of Four Cases

2001 ◽  
Vol 10 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Yoko Misu ◽  
Shi-Xu Jiang ◽  
Yukifumi Yokota ◽  
Masahiko Shibata ◽  
Osamu Shinohara ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Clinicopathological Features ◽  
Weiss Criteria

scholarly journals Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma

2020 ◽  
Vol 9 (7) ◽  
pp. 705-714
Author(s):  
Anne Jouinot ◽  
Juliane Lippert ◽  
Martin Fassnacht ◽  
Bruno de La Villeon ◽  
Amandine Septier ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Molecular Markers ◽  
Adrenocortical Carcinoma ◽  
Somatic Mutations ◽  
Intratumor Heterogeneity ◽  
Tissue Samples ◽  
Molecular Alterations ◽  
Prognostic Assessment ◽  
Genomic Studies ◽  
Chromosome Alteration

Background: The prognosis of adrenocortical carcinoma (ACC) is heterogeneous. Genomic studies have identified ACC subgroups characterized by specific molecular alterations, including features measured at DNA level (somatic mutations, chromosome alterations, DNA methylation), which are closely associated with outcome. The aim of this study was to evaluate intratumor heterogeneity of prognostic molecular markers at the DNA level. Methods: Two different tissue samples (primary tumor, local recurrence or metastasis) were analyzed in 26 patients who underwent surgery for primary or recurrent ACC. DNA-related biomarkers with prognostic role were investigated in frozen and paraffin-embedded samples. Somatic mutations of p53/Rb and Wnt/β-catenin pathways were assessed using next-generation sequencing (n = 26), chromosome alteration profiles were determined using SNP arrays (n = 14) and methylation profiles were determined using four-gene bisulfite pyrosequencing (n = 12). Results: Somatic mutations for ZNRF3, TP53, CTNN1B and CDKN2A were found in 7, 6, 6 and 4 patients, respectively, with intratumor heterogeneity in 8/26 patients (31%). Chromosome alteration profiles were ‘Noisy’ (numerous and anarchic alterations) in 8/14 and ‘Chromosomal’ (extended patterns of loss of heterozygosity) in 5/14 of the study samples. For these profiles, no intratumor heterogeneity was observed. Methylation profiles were hypermethylated in 5/12 and non-hypermethylated in 7/12 of the study samples. Intratumor heterogeneity of methylation profiles was observed in 2/12 patients (17%). Conclusions: Intratumor heterogeneity impacts DNA-related molecular markers. While somatic mutation can differ, prognostic DNA methylation and chromosome alteration profile seem rather stable and might be more robust for the prognostic assessment.

scholarly journals Clinicopathological Features, Treatment Outcomes, and Prognostic Factors in Adrenocortical Carcinoma: A Single-Center Experience

2021 ◽  
Vol 7 (3) ◽  
pp. 133-138
Author(s):  
Nazım Can DEMİRCAN ◽  
Tuğba AKIN TELLİ ◽  
Tuğba BAŞOĞLU ◽  
Rukiye ARIKAN ◽  
Alper YAŞAR ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Treatment Outcomes ◽  
Adrenocortical Carcinoma ◽  
Clinicopathological Features ◽  
Single Center ◽  
Single Center Experience

433 A comparison of clinicopathological features and molecular markers in British and Nigerian women with breast cancer

2004 ◽  
Vol 2 (8) ◽  
pp. 129-130 ◽  
Author(s):  
I.D. Gukas ◽  
B.A. Jennings ◽  
B.M. Mandong ◽  
A. Girling ◽  
G. Igun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Markers ◽  
Clinicopathological Features ◽  
Nigerian Women

scholarly journals Clinicopathological features and outcomes of adrenocortical carcinoma: A single institution experience

2019 ◽  
Vol 35 (3) ◽  
pp. 213
Author(s):  
FrancisVadakkumparambil James ◽  
LekhaMadhavan Nair ◽  
KM Jagathnath Krishna ◽  
Aswin Kumar ◽  
Susan Mathews ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
Clinicopathological Features ◽  
Single Institution

scholarly journals Nonfunctioning adrenocortical carcinoma: a study of 12 cases

1970 ◽  
Vol 2 (3) ◽  
pp. 193-197
Author(s):  
S Ghanghoria ◽  
P Raje ◽  
R Jain ◽  
A Ghanghoria
Keyword(s):  
Adrenocortical Carcinoma ◽  
Epithelial Membrane Antigen ◽  
Clinicopathological Features ◽  
Adrenal Cortical Carcinoma ◽  
High Grade ◽  
Histological Features ◽  
Histological Criteria ◽  
Adrenal Cortical Tumor ◽  
High Grade Carcinoma ◽  
Weiss Criteria

Background: Adrenal cortical carcinoma is a rare malignant tumor. Several systems were proposed for diagnosis and evaluation of adrenocortical tumors.Weiss system is most commonly used method for assessment of malignancy, but only few studies has applied this criteria, for assesement of prognosis. The aim of this study was to analyzethe histological features & immunostaining status of adrenocortical carcinoma diagnosed according to Weiss criteria and correlate the data with patient clinical finding and outcomes. Materials and Methods: In this study clinicopathological features of 12 cases were reviewed and diagnosed as adrenocortical carcinoma on the basis of Weiss criteria and immunostaining. Grading was done according to the nine histopathological criteria of Weiss and is applied for assessment of prognosis. Each tumor was labeled malignant, when it scored ≥4 point of this histological criteria, tumors with ≤3 points were considered as adenoma and not included in the series. Immunostains applied were, Vimentin, Cytokeratin, synaptophysin, chromogranin, Vinyl mandilic acid, epithelial membrane antigen and Melan A. Results: All cases studied, presented at least four of the Weiss criteria and thus diagnosed as adrenocortical carcinoma. Patients with 7 and more score of Weiss criteria is considered as high grade carcinoma. Immunostains, have role in the diagnosis of adrenal cortical tumor, but does not have any significant clinical outcome.Conclusion: Weiss criteria was found to be a good prognostic factor in adrenal cortical carcinoma. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6020 JPN 2012; 2(3): 193-197

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