scholarly journals Plasma C-peptide level is inversely associated with family history of type 2 diabetes in Korean type 2 diabetic patients

2010 ◽  
Vol 57 (10) ◽  
pp. 931-938 ◽  
Author(s):  
Jin Ook Chung ◽  
Dong Hyeok Cho ◽  
Dong Jin Chung ◽  
Min Young Chung
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Peptide Level ◽  
History Of ◽  
Korean Type ◽  
Type 2 Diabetic

scholarly journals Risk Factors of Hypertension among Type 2 Diabetic Patients in Imo state, South East of Nigeria

2020 ◽  
pp. 65-72
Author(s):  
Ugonma, Winnie Dozie ◽  
Nnenna, Vivian Okonkwo ◽  
Okwuchi, Blessed Nworuh ◽  
Somtochukwu, Mercy Orji ◽  
Chidozie Joakin Nwaokoro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Dietary Pattern ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
History Of ◽  
Family History Of Hypertension ◽  
Type 2 Diabetic

Background: Hypertension is among the important causes of non-communicable disease burden worldwide. It has raised public health concerns in both developed and developing nations. It mostly occurs in patients with diabetes and the prevalence depends on duration, type and age of the patient. The study aimed at determining the risk factors of hypertension among type 2 diabetic patients in Imo State, Nigeria. Methods: A hospital-based descriptive survey design involving 50 patients attending hospital was used. Structured questionnaire complemented with interview schedule was used to collect data from the respondents. Data were analyzed using frequency and mean score. Hypotheses were tested using Chi-square at 5% significance level. Results: The result showed that the majority (70.0%) of the patients was hypertensive, 54.0% of the patients used dietary control and drugs in the treatment of the diseases. Furthermore, it was found that 54.0% ate salty foods always, 58.0% of the patients added extra table salt in their meals, 54.0% ate canned foods and 82.0% took sugary drinks always. It was also found that 66.0% ate always from restaurants and 58.0% ate more of starchy foods. The result further showed that 74.0% of the patients avoided physical exercise and 70.0% indicated that doing stress works made them get anxious. Eighty percent of the patients had hypertension in their family history and the 74.0% indicated it was their brother/sister. The X2 result showed a significantly association between family history of hypertension and type 2 diabetes X2(121, N = 50) = 187, p = 0.000. It was also found that dietary pattern was significantly associated with risk of type 2 diabetes X2(121, N = 50) = 187, p = 0.000. Conclusion: Dietary pattern and family history of hypertension were significantly associated with type 2 diabetes. It was recommended that sensitization campaigns be organized to educate women on the effect of diets on diabetes. Also, family history of hypertension should be ascertained from patients to ensure early detection and treatment of diabetes.

scholarly journals Basal C-peptide Level as a Surrogate Marker of Subclinical Atherosclerosis in Type 2 Diabetic Patients

2011 ◽  
Vol 35 (1) ◽  
pp. 41 ◽  
Author(s):  
Sung-Tae Kim ◽  
Byung-Joon Kim ◽  
Dong-Mee Lim ◽  
In-Geol Song ◽  
Jang-Han Jung ◽  
...  
Keyword(s):  
Subclinical Atherosclerosis ◽  
Surrogate Marker ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Peptide Level ◽  
Type 2 Diabetic

scholarly journals The effects of obesity along with other risk factors on type 2 diabetic patients in the northwest of Libya

2020 ◽  
Vol 8 (2) ◽  
pp. 117-123
Author(s):  
Khaled Ali ALawaini ◽  
Mustafa Ali Abugila
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Face To Face ◽  
High Fasting Plasma Glucose ◽  
Type 2 Diabetic

Type 2 diabetes has several causes, such as family history, age, physical inactivity, and unhealthy food. Obesity is a significant cause of type 2 diabetes (T2D). Microvascular and macrovascular complications are associated with long-term diabetes. However, the main objective in this study is to search for complications and risk factors related to diabetes. Therefore, 472 diabetic patients with type 2 diabetes from northwest Libya participated in this study. Face-to-face interviews conducted using a questionnaire asking each patient information about name, age, sex, duration of disease, family history, and measured body mass index (BMI). A biochemical analysis (FPG, HbA1c, cholesterol, and triglyceride) was also performed on diabetic patients. Our results showed that 60.6% of type 2 diabetic patients had a positive family history. Poor glycemic control identified by high fasting plasma glucose (FPG) 186±9 mg/dl, and glycated hemoglobin was (HbA1C) 8.36%±1.8.

scholarly journals Decrement of postprandial insulin secretion determines the progressive nature of type-2 diabetes

2006 ◽  
Vol 155 (4) ◽  
pp. 615-622 ◽  
Author(s):  
Wan Sub Shim ◽  
Soo Kyung Kim ◽  
Hae Jin Kim ◽  
Eun Seok Kang ◽  
Chul Woo Ahn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Diabetic Patients ◽  
Β Cell ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Duration Of Diabetes ◽  
Type 2 Diabetic ◽  
Postprandial Insulin

Objective: Type-2 diabetes is a progressive disease. However, little is known about whether decreased fasting or postprandial pancreatic β-cell responsiveness is more prominent with increased duration of diabetes. The aim of this study was to evaluate the relationship between insulin secretion both during fasting and 2 h postprandial, and the duration of diabetes in type-2 diabetic patients. Design: Cross-sectional clinical investigation. Methods: We conducted a meal tolerance test in 1466 type-2 diabetic patients and calculated fasting (M0) and postprandial (M1) β-cell responsiveness. Results: The fasting C-peptide, postprandial C-peptide, M0, and M1 values were lower, but HbA1c values were higher, in patients with diabetes duration > 10 years than those in other groups. There was no difference in the HbA1c levels according to the tertiles of their fasting C-peptide level. However, in a group of patients with highest postprandial C-peptide tertile, the HbA1c values were significantly lower than those in other groups. After adjustment of age, sex, and body mass index (BMI), the duration of diabetes was found to be negatively correlated with fasting C-peptide (γ = −0.102), postprandial C-peptide (γ = −0.356), M0 (γ = −0.263), and M1 (γ = −0.315; P < 0.01 respectively). After adjustment of age, sex, and BMI, HbA1c was found to be negatively correlated with postprandial C-peptide (γ = −0.264), M0 (γ = −0.379), and M1 (γ = −0.522), however, positively correlated with fasting C-peptide (γ = 0.105; P < 0.01 respectively). In stepwise multiple regression analysis, M0, M1, and homeostasis model assessment for insulin resistance (HOMA-IR) emerged as predictors of HbAlc after adjustment for age, sex, and BMI (R2 = 0.272, 0.080, and 0.056 respectively). Conclusions: With increasing duration of diabetes, the decrease of postprandial insulin secretion is becoming more prominent, and postprandial β-cell responsiveness may be a more important determinant for glycemic control than fasting β-cell responsiveness.

scholarly journals The Management of Type 2 Diabetic Patients with Hypoglycemic Agents

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
G. P. Carnevale Schianca ◽  
D. Sola ◽  
L. Rossi ◽  
G. P. Fra ◽  
E. Bartoli
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Scientific Evidence ◽  
Clinical Aspect ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Aims And Scope ◽  
Type 2 Diabetic

Aims and Scope. Aims of the paper are to suggest the best treatment to improve the glycemic control in patients with Type 2 diabetes using hypoglycemic agents, in particularly, we think that every patient is different from another one in terms of BMI, family history, duration of the disease and so on. We propose for every clinical aspect the best hypoglycemic agents to use, considering the scientific evidence and physiopathology.

scholarly journals Small Intestinal Glucose Delivery Affects the Lowering of Blood Glucose by Acute Vildagliptin in Type 2 Diabetes

2016 ◽  
Vol 101 (12) ◽  
pp. 4769-4778 ◽  
Author(s):  
Tongzhi Wu ◽  
Xiang Zhang ◽  
Laurence G. Trahair ◽  
Michelle J. Bound ◽  
Tanya J. Little ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Emptying ◽  
Plasma Glucose ◽  
Glucose Infusion ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Glucose Lowering ◽  
C Peptide ◽  
Type 2 Diabetic

Context: The rate of gastric emptying is an important determinant of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion and may influence the magnitude of glucose lowering by dipeptidyl peptidase-4 (DPP-4) inhibitors. Objective: To evaluate the effects of the DPP-4 inhibitor, vildagliptin (VILD), during intraduodenal (ID) glucose infusion at 2 different rates within the physiological range of gastric emptying, in type 2 diabetes. Participants and Design: A total of 16 diet-controlled type 2 diabetic patients were studied on 4 separate days in double-blind, randomized, fashion. On each day, either 5-mg VILD or placebo (PLBO) was given 60 minutes before a 120-minute ID glucose infusion at 2 or 4 kcal/min (ID2 or ID4). Plasma glucose and hormones were measured frequently. Results: Plasma glucose, insulin, C-peptide, glucagon, total GIP, and total and intact GLP-1 concentrations were higher during ID4 than ID2 (P &lt; .01 for each). Compared with PLBO, VILD was associated with higher intact GLP-1, insulin, and C-peptide and lower glucose and total GIP and GLP-1 (P &lt; .01 for each), without affecting glucagon. There were significant interactions between the rate of ID glucose and VILD treatment on plasma glucose, intact and total GLP-1, and GIP (P &lt; .05 for each) but not insulin, C-peptide, or glucagon. The reduction in glucose and the increment in intact GLP-1 after VILD vs PLBO were 3.3- and 3.8-fold greater, respectively, during ID4 compared with ID2. Conclusions/Interpretation: These observations warrant further study to clarify whether type 2 diabetic patients with relatively more rapid gastric emptying have greater glucose lowering during treatment with DPP-4 inhibitors.

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