scholarly journals A Common P2 Promoter Polymorphism of the Hepatocyte Nuclear Factor-4α Gene Is Associated with Insulin Secretion in Non-Obese Japanese with Type 2 Diabetes

2008 ◽  
Vol 55 (6) ◽  
pp. 999-1004 ◽  
Author(s):  
Ayumi TOKUNAGA ◽  
Yukio HORIKAWA ◽  
Etsuko FUKUDA-AKITA ◽  
Kohei OKITA ◽  
Hiromi IWAHASHI ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Promoter Polymorphism ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4Α

scholarly journals P2 Promoter Variants of the Hepatocyte Nuclear Factor 4α Gene Are Associated With Type 2 Diabetes in Mexican Americans

Diabetes ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 513-517 ◽  
Author(s):  
Donna M. Lehman ◽  
Dawn K. Richardson ◽  
Chris P. Jenkinson ◽  
Kelly J. Hunt ◽  
Thomas D. Dyer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mexican Americans ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4Α

scholarly journals Prediabetes Is Associated withHNF-4αP2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Changyi Wang ◽  
Sihan Chen ◽  
Tao Zhang ◽  
Zhongwei Chen ◽  
Shengyuan Liu ◽  
...  
Keyword(s):  
Chinese Population ◽  
Case Control Study ◽  
Meta Analysis ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Control Study

Background. Controversy remains for the association between hepatocyte nuclear factor4α(HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk.Methods. Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 ofHNF-4αin the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk.Results. Polymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16–1.68,P=0.0001) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14–1.92,P=0.003) after adjusting for age and body mass index (BMI). In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis.Conclusions. Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.

scholarly journals Hepatocyte Nuclear Factor-4  P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

Diabetes ◽  
2006 ◽  
Vol 55 (5) ◽  
pp. 1260-1264 ◽  
Author(s):  
K. Hara ◽  
M. Horikoshi ◽  
H. Kitazato ◽  
C. Ito ◽  
M. Noda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Japanese Population ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4 ◽  
Promoter Haplotypes

scholarly journals Common Variants of the Hepatocyte Nuclear Factor-4  P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Diabetes ◽  
2004 ◽  
Vol 53 (11) ◽  
pp. 3002-3006 ◽  
Author(s):  
M. N. Weedon ◽  
K. R. Owen ◽  
B. Shields ◽  
G. Hitman ◽  
M. Walker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Common Variants ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4

Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4α gene and insulin secretion index in Thais

2007 ◽  
Vol 44 (4) ◽  
pp. 227-232 ◽  
Author(s):  
W. Jongjaroenprasert ◽  
S. Chanprasertyothin ◽  
A. Kongsuksai ◽  
P. Bunnag ◽  
G. Puavilai ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Genetic Variations ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Hepatocyte Nuclear Factor 4Α

Association between Genetic Polymorphisms in Hepatocyte Nuclear Factor 4α and Type 2 Diabetes in Koreans

2006 ◽  
Vol 30 (1) ◽  
pp. 10
Author(s):  
Eun Jung Lee ◽  
Soo Heon Kwak ◽  
Sun Wook Jo ◽  
Hyung Jin Choi ◽  
Hyoung Doo Shin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Polymorphisms ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 4Α
Sign in / Sign up

Export Citation Format

Share Document