scholarly journals Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control

2007 ◽  
Vol 54 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Satomi TAKAHASHI ◽  
Hiroshi UCHINO ◽  
Tomoaki SHIMIZU ◽  
Akio KANAZAWA ◽  
Yoshifumi TAMURA ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Glycated Hemoglobin ◽  
Glycated Albumin ◽  
Diabetic Patients ◽  
Short Term ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals The effect of short-term intensive insulin therapy in newly-diagnosed Type-2 diabetic patients

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Cengiz Karacaer ◽  
Taner Demirci ◽  
Hasret Cengiz ◽  
Ceyhun Varim ◽  
Ali Tamer
Keyword(s):  
Glycemic Control ◽  
Insulin Therapy ◽  
Intensive Insulin Therapy ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Short Term ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objectives: We aimed to determine the effect of short-term intensive insulin therapy (SIIT) on long-term glycemic control in newly-diagnosed Type-2 diabetes mellitus (nT2DM) patients. Methods: In this retrospectively study conducted at Sakarya University Medical Faculty Training and Research Hospital Outpatient Clinic between 2016 and 2019, 65 nT2DM patients were enrolled soon after their SIIT was initiated and were followed for at least a year. Intensive insulin treatment was discontinued after three or 12 months in a total of 65 (23–73-year-old) patients who had been newly diagnosed with T2DM. Intensive insulin therapy was discontinued when glycemic control and the target Glycated Hemoglobin (HbA1c) level had been attained, after which oral anti-diabetic drug (OAD), long-term insulin, and diet therapies were pursued. Results: There was a significant decrease in mean HbA1c from 11.25±1.96% to 6.67±1.07%. Fasting plasma glucose (FPG) was found to be an independent predictor of whether intensive insulin therapy could be discontinued after three months in a model that included FPG, HbA1c, and body mass index measured at baseline. Patients with FPG >13.8 mmol/L were 7.6 times more likely to require intensive insulin therapy beyond three months. There were significant decreases in HbA1c and low-density lipoprotein-cholesterol concentration, but no change in C-peptide between baseline and 3 months of therapy. Conclusion: These results demonstrate that in nT2DM patients, intensive insulin therapy could be effective on long-term glycemic control and high FPG prior to three months of SIIT may predict poor long-term glycemic control. doi: https://doi.org/10.12669/pjms.37.7.4013 How to cite this:Karacaer C, Demirci T, Cengiz H, Varim C, Tamer A. The effect of short-term intensive insulin therapy in newly-diagnosed Type-2 diabetic patients. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4013 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

A STUDY TO CORRELATE TOTAL CALCIUM AND GLYCATED HEMOGLOBIN IN TYPE-2 DIABETES PATIENTS.

2021 ◽  
pp. 62-63
Author(s):  
V Indhumathi ◽  
M. Priyatharshini ◽  
P. Muraliswaran ◽  
S Dhanoushyaa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Glycated Hemoglobin ◽  
Diabetic Patients ◽  
Total Calcium ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Background: The risk for developing diabetic complications are related to glycemic control which is measured by estimating the glycated hemoglobin (HbA1c) level. Calcium increases the GLUT 4 activity. Change in calcium alters the insulin receptor phosphorylation, and decreases the activity of glucose transporter Objective: To nd out the correlation between serum Calcium and glycated Haemoglobin in Type 2 Diabetes Mellitus patients. Materials And Methodology: A cross sectional study which included 100 type 2 Diabetes mellitus patients, divided into 2 groups based on HbA1c levels. Group 1 : Type 2 Diabetic patients with HbA1c more than 7 percent and Group 2 : Type 2 Diabetic patients with HbA1c less than 7 percent. Total calcium level was correlated with glycated hemoglobin level. Statistical analysis was done using unpaired t test. Result: The mean value of serum total calcium was lower in the diabetic group whose HbA1c was > 7 (p value – 0.000) when compared to the diabetic group whose HbA1c was <7. A strong negative correlation (r = -0.391) between calcium and HbA1c in the T2 diabetic patients with HbA1c >7 (p = 0.000) was observed. Conclusion: Alteration in calcium levels will have adverse effects on insulin secretion and release. Estimating the level of calcium becomes important to know the status of insulin in diabetic patients and correlating the levels of HbA1c and Serum Calcium in Type 2 DM patients, can monitor the levels of glycemic control and the risk of development of complications. Calcium supplementation to the diabetic patients can help in better glycemic control and prevent diabetes related complications

scholarly journals Ischemia modified albumin among type 2 diabetic patients visiting a tertiary care center of Kathmandu

2020 ◽  
Vol 10 (3) ◽  
pp. 74-78
Author(s):  
Sangita Thapa ◽  
Rabindra Jang Rayamajhi ◽  
Surakshya Gautam ◽  
Sirjana Dahal
Keyword(s):  
Oxidative Stress ◽  
Glycemic Control ◽  
Glycated Hemoglobin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Ischemia Modified Albumin ◽  
Group 2 ◽  
Type 2 Diabetic ◽  
Group 1

Background: Chronic hyperglycemia in diabetes may increase oxidative stress causing ischemia and long-term complications of diabetes. It may also alter albumin, increasing the concentration of serum ischemia modified albumin. The present study was conducted to estimate serum isch­emia modified albumin level and to assess its relationship with parameters of glycemic control in diabetic patients. Methods: In this study, 130 type 2 diabetic patients were enrolled and blood samples were ana­lyzed for ischemia modified albumin, glycated hemoglobin, fasting and postprandial blood glu­cose. Parameters of glycemic control were estimated using routine standard methods and serum ischemia modified albumin was measured manually by spectrophotometric cobalt-albumin bind­ing assay. Participants with glycated hemoglobin level less than 7% were labeled as group 1 and participants with glycated hemoglobin value more than or equal to 7% were labeled as group 2. Results: Group 2 participants had significantly higher mean serum ischemia modified albumin as compared to group 1 (p<0.001). There was significant positive correlation between ischemia modi­fied albumin and parameters of glycemic control; glycated hemoglobin (r=0.300, p=0.001), fasting blood glucose (r=0.239, p=0.006), postprandial blood glucose (r=0.318, p<0.001). However the relationship of ischemia modified albumin with age, body mass index and duration of diabetes were statistically insignificant. Conclusions: The present study shows increase in serum ischemia modified albumin with increase in all three glycemic parameters. This finding suggests that ischemia modified albumin can be used as a marker of hyperglycemia induced oxidative stress in diabetes.

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