scholarly journals Longitudinal Study of Patients with Idiopathic Isolated TSH Deficiency: Possible Progression of Pituitary Dysfunction in Lymphocytic Adenohypophysitis

2006 ◽  
Vol 53 (5) ◽  
pp. 593-601 ◽  
Author(s):  
Ken-Ichi HASHIMOTO ◽  
Noriyoshi YAMAKITA ◽  
Tsuneko IKEDA ◽  
Takashi MATSUHISA ◽  
Akio KUWAYAMA ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Pituitary Dysfunction ◽  
Lymphocytic Adenohypophysitis ◽  
Tsh Deficiency

scholarly journals Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis

2002 ◽  
pp. 767-775 ◽  
Author(s):  
S Tanaka ◽  
KI Tatsumi ◽  
M Kimura ◽  
T Takano ◽  
Y Murakami ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Pituitary Gland ◽  
Pituitary Hormones ◽  
Lymphocytic Hypophysitis ◽  
Specific Factor ◽  
Pituitary Macroadenoma ◽  
Specific Proteins ◽  
Lymphocytic Adenohypophysitis ◽  
Pituitary Enlargement ◽  
Tsh Deficiency

OBJECTIVE: Several reports have described antipituitary antibodies by immunofluorescent or immunoblotting methods in patients with lymphocytic hypophysitis. However, with the exception of the pituitary hormones, individual antigens specific for the pituitary gland have not been studied. To understand the pathogenesis of lymphocytic hypophysitis and to diagnose this disease efficiently, we studied the presence of autoantibodies against three pituitary-specific proteins, GH and two novel pituitary-specific proteins, namely, pituitary gland specific factor 1a (PGSF1a) and PGSF2. DESIGN: Seventeen patients with lymphocytic hypophysitis, all of whom had pituitary enlargement (5 with lymphocytic adenohypophysitis and 12 with lymphocytic infundibuloneurohypophysitis, including 3 of the latter group proven by biopsy), and 14 patients with hypopituitarism without pituitary enlargement (10 with isolated ACTH deficiency and 4 with idiopathic TSH deficiency) were studied, and compared with 11 patients with non-functioning pituitary macroadenoma, 31 patients with other autoimmune diseases, and 36 healthy controls. METHODS: The presence of each antibody was studied by radioligand assay using recombinant human (35)S-labeled protein. RESULTS: Three (18%) patients with lymphocytic hypophysitis having pituitary enlargement, five (36%) patients with hypopituitarism without pituitary enlargement and three (9.7%) patients with other autoimmune diseases were positive for one or more of the antibodies studied. CONCLUSIONS: Anti-human GH, anti-PGSF1a, and anti-PGSF2 antibodies were detected in patients with lymphocytic hypophysitis and other hypopituitarism, but were not detected in patients with non-functioning pituitary macroadenoma. Detection of these antibodies may be useful for the diagnosis of lymphocytic hypophysitis.

School Achievement and Adult Qualifications among Adoptees: A Longitudinal Study

1998 ◽  
Vol 39 (5) ◽  
pp. 669-685 ◽  
Author(s):  
Barbara Maughan ◽  
Stephan Collishaw ◽  
Andrew Pickles
Keyword(s):  
Longitudinal Study ◽  
School Achievement

A Longitudinal Posthumous Study of Letter Writing in a Late Elderly Case

2015 ◽  
Vol 20 (1) ◽  
pp. 22-33
Author(s):  
Angel Ball ◽  
Jean Neils-Strunjas ◽  
Kate Krival
Keyword(s):  
Longitudinal Study ◽  
Elderly Woman ◽  
Semantic Content ◽  
Cognitive Status ◽  
Letter Writing ◽  
Linguistic Performance ◽  
Errors Analysis ◽  
Normal Status

This study is a posthumous longitudinal study of consecutive letters written by an elderly woman from age 89 to 93. Findings reveal a consistent linguistic performance during the first 3 years, supporting “normal” status for late elderly writing. She produced clearly written cursive form, intact semantic content, and minimal spelling and stroke errors. A decline in writing was observed in the last 6–9 months of the study and an analysis revealed production of clausal fragmentation, decreasing semantic clarity, and a higher frequency of spelling, semantic, and stroke errors. Analysis of writing samples can be a valuable tool in documenting a change in cognitive status differentiated from normal late aging.

1344: Metabolic Factors Associated with Benign Prostatic Hyperplasia: The Baltimore Longitudinal Study of Aging

2006 ◽  
Vol 175 (4S) ◽  
pp. 432-433 ◽  
Author(s):  
J. Kellogg Parsons ◽  
H. Ballentine Carter ◽  
Alan W. Partin ◽  
B. Gwen Windham ◽  
E. Jeffrey Metter ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Metabolic Factors ◽  
Factors Associated ◽  
Baltimore Longitudinal Study
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