scholarly journals Effect of Voluntary Wheel-Running on Insulin Sensitivity and Responsiveness in High-Fat-Fed Rats.

2001 ◽  
Vol 48 (5) ◽  
pp. 551-555 ◽  
Author(s):  
YANQING HAN ◽  
YOSHIHARU OSHIDA ◽  
LING LI ◽  
KEIICHI KOSHINAKA ◽  
NORIYUKI FUKU ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Wheel Running ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats

1999 ◽  
Vol 86 (4) ◽  
pp. 1374-1380 ◽  
Author(s):  
Deborah A. Podolin ◽  
Yuren Wei ◽  
Michael J. Pagliassotti
Keyword(s):  
High Fat Diet ◽  
Corn Oil ◽  
Wheel Running ◽  
Whole Body ◽  
Free Access ◽  
Fat Pad ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

The purpose of the present study was to determine the effects of diet composition and exercise on glycerol and glucose appearance rate (Ra) and on nonglycerol gluconeogenesis (Gneo) in vivo. Male Wistar rats were fed a high-starch diet (St, 68% of energy as cornstarch, 12% corn oil) for a 2-wk baseline period and then were randomly assigned to one of four experimental groups: St ( n = 7), high-fat (HF; 35% cornstarch, 45% corn oil; n = 8), St with free access to exercise wheels (StEx; n = 7), and HF with free access to exercise wheels (HFEx; n = 7). After 8 wk, glucose Rawhen using [3-3H]glucose, glycerol Rawhen using [2H5]glycerol (estimate of whole body lipolysis), and [3-13C]alanine incorporation into glucose (estimate of alanine Gneo) were determined. Body weight and fat pad mass were significantly ( P < 0.05) decreased in exercise vs. sedentary animals only. The average amount of exercise was not significantly different between StEx (3,212 ± 659 m/day) and HFEx (3,581 ± 765 m/day). The ratio of glucose to alanine enrichment and absolute glycerol Ra(μmol/min) were higher ( P < 0.05) in HF and HFEx compared with St and StEx rats. In separate experiments, the ratio of3H in C-2 to C-6 of glucose from3H2O (estimate of Gneo from pyruvate) was also higher ( P < 0.05) in HF ( n = 5) and HFEx ( n = 5), compared with St ( n = 5) and StEx ( n = 5) rats. Voluntary wheel running did not significantly increase estimated alanine or pyruvate Gneo or absolute glycerol Ra. Voluntary wheel running increased ( P< 0.05) glycerol Rawhen normalized to fat pad mass. These data suggest that a high-fat diet can increase in vivo Gneo from precursors that pass through pyruvate. They also suggest that changes in the absolute rate of glycerol Ramay contribute to the high-fat diet-induced increase in Gneo.

scholarly journals Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0130259 ◽  
Author(s):  
Thomas H. Reynolds ◽  
Sayani Banerjee ◽  
Vishva Mitra Sharma ◽  
Jacob Donohue ◽  
Sandrine Couldwell ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Wheel Running ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

scholarly journals PO-034 Effect of Voluntary Exercise on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Wenhao Zong ◽  
Yang Liu ◽  
Lulu Dai ◽  
Guijun Dong
Keyword(s):  
Articular Cartilage ◽  
Knee Osteoarthritis ◽  
High Fat Diet ◽  
Wheel Running ◽  
Cartilage Thickness ◽  
Obese Mice ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Exercise ◽  
Voluntary Wheel

Objective To examine the effect of voluntary wheel-running exercise on cartilage morphology of knee osteoarthritis(KOA) in obese mice induced by high-fat diet,and explore the protective role of 4 weeks voluntary wheel-running exercise on KOA,finally providing effective experimental evidence for clinical treatment of knee osteoarthritis. Methods C57BL/6J mice were randomly assigned to the C-Sed group,C-Ex group,HF-Sed group and HF-Ex group.The control groups were fed a control diet(13.5% kcal from fat),and the high-fat groups were fed a high-fat diet(60% kcal from fat).After feeding 8 weeks different diets,the exercise groups were starting running.In order to examine the effect of voluntary wheel-running exercise on cartilage morphology of KOA,the joint of knee were harvested to be fixed,decalcified and embedded in paraffin,and the four-micrometer-thick sections were stained with both HE and toluidine blue . Results After feeding twelve weeks different diets,the body mass of the high-fat diet group mice has a significant increase,which demonstrates that high-fat diet could successfully induce the mice obese.From the results of HE and toluidine blue,in comparison to the C-Sed group,the surface of the knee articular cartilage in the HF-Sed group was not intact and smooth,and the thickness of articular cartilage has a significant decrease（p<0.001）;contrary to the HF-Sed group,the surface of the knee articular cartilage in HF-Ex group was slightly smooth,and there was significant increase in cartilage thickness. Conclusions Four weeks voluntary wheel-running exercise can increase cartilage thickness ,decrease the Mankin’s score and delay the degeneration of knee cartilage in obese mice.To conclude,the short-term wheel-running exercise protects against obesity-induced KOA.

scholarly journals High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement

2017 ◽  
Vol 8 ◽  
Author(s):  
Heather L. Vellers ◽  
Ayland C. Letsinger ◽  
Nicholas R. Walker ◽  
Jorge Z. Granados ◽  
J. Timothy Lightfoot
Keyword(s):  
Wheel Running ◽  
Sex Hormone ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
High Sugar ◽  
Voluntary Wheel

Introduction Of A High-fat/sucrose Diet Modulates Voluntary Wheel Running Activity In Adult Female Rats

2017 ◽  
Vol 49 (5S) ◽  
pp. 440
Author(s):  
Jon-Philippe K. Hyatt ◽  
Lindsay Caprio ◽  
Elisa J. Bienenstock ◽  
Jung A. Kim ◽  
Gary E. McCall
Keyword(s):  
Adult Female ◽  
Wheel Running ◽  
Female Rats ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Sucrose Diet ◽  
Voluntary Wheel

Voluntary wheel-running attenuates insulin and weight gain and affects anxiety-like behaviors in C57BL6/J mice exposed to a high-fat diet

2016 ◽  
Vol 310 ◽  
pp. 1-10 ◽  
Author(s):  
Jasmin A. Hicks ◽  
Aikaterini Hatzidis ◽  
Nicole L. Arruda ◽  
Rachel R. Gelineau ◽  
Isabella Monteiro De Pina ◽  
...  
Keyword(s):  
Weight Gain ◽  
High Fat Diet ◽  
Wheel Running ◽  
High Fat ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Voluntary wheel running reduces colon inflammation in female but not male mice fed a high-fat diet

2019 ◽  
Vol 15 (1) ◽  
pp. 35-47
Author(s):  
P.J. Wisniewski ◽  
G. Wahler ◽  
C. Gardner ◽  
S.A. Lightfoot ◽  
L.B. Joseph ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Wheel Running ◽  
Distal Colon ◽  
High Fat ◽  
Spatial Organisation ◽  
Epithelial Surface ◽  
Voluntary Wheel Running ◽  
Female Mice ◽  
Mucin 2 ◽  
Voluntary Wheel

The influence of diet and exercise on intestinal mucus and the spatial organisation of the microbiota is poorly understood. Though, it has been observed that the spatial organisation of the microbiota can be altered extensively in Crohn’s disease and ulcerative colitis. This study aims to investigate the pathophysiological events in mouse colon that are associated with a high fat diet and lack of exercise. Forty-eight, 6-week old C57BL/6NTac male and female mice were fed a normal or high-fat diet for 12 weeks and randomly assigned to free wheel running or sedentary groups. After 12 weeks, animals were sacrificed and distal colon tissue sections with and without faecal material were fixed for histomorphometric analysis, immunohistochemistry for cyclooxygenase-2 and mucin-2, or fluorescent in situ hybridization with the universal bacterial probe EUB338 (5’-GCTGCCTCCCGTAGGAGT-3’). Goblet cell counts and distance between the microbiota and epithelial surface were determined using ImageJ software. All mice had a normal colon morphology except for high-fat fed female mice who ran, demonstrating a reduction of goblet cells that approached significance and a reduced mucin-2 expression. Voluntary wheel running attenuated high-fat diet induced COX-2 expression in female mice only. The distance between the microbiota and epithelial surface remained the same. Taken together, these results show that voluntary wheel running protect against high-fat diet-induced inflammation in the distal colon of female mice and responses to changes in host behaviour may differ between sex.

Sign in / Sign up

Export Citation Format

Share Document