scholarly journals Vitamin D Receptor Genotype Is Associated with Cortical Bone Loss in Japanese Patients with Primary Hyperparathyroidism.

1998 ◽  
Vol 45 (1) ◽  
pp. 123-125 ◽  
Author(s):  
TATSUYA KOBAYASHI ◽  
TOSHITSUGU SUGIMOTO ◽  
AKIRA KOBAYASHI ◽  
KAZUO CHIHARA
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Primary Hyperparathyroidism ◽  
Cortical Bone ◽  
Vitamin D Receptor ◽  
Japanese Patients ◽  
Cortical Bone Loss

scholarly journals Vitamin D deficiency is associated with cortical bone loss and fractures in the elderly

2019 ◽  
Vol 181 (5) ◽  
pp. 509-517 ◽  
Author(s):  
F P Paranhos-Neto ◽  
L Vieira Neto ◽  
M Madeira ◽  
A B Moraes ◽  
L M C Mendonça ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Vitamin D Deficiency ◽  
Cortical Bone ◽  
Vertebral Fractures ◽  
Elderly Women ◽  
Bone Microarchitecture ◽  
Quantitative Computed Tomography ◽  
X Rays ◽  
Cortical Bone Loss

Introduction The role of vitamin D on bone microarchitecture and fragility is not clear. Objective To investigate whether vitamin D deficiency (25(OH)D <20 ng/mL) increases cortical bone loss and the severity of fractures. Design Cross-sectional study of 287 elderly women with at least one prevalent low-impact fracture. Methods Biochemistry, X-rays to identify vertebral fractures (VFs) and to confirm non-vertebral fractures (NonVFs), and high-resolution peripheral quantitative computed tomography (HR-pQCT) to evaluate bone microstructure. Results Serum 25(OH)D levels were associated with body mass index (BMI: r = −0.161, P = 0.006), PTH (r = −0.165; P = 0.005), CTX (r = −0.119; P = 0.043) and vBMD at cortical bone (Dcomp: r = 0.132; P = 0.033) and entire bone (D100: r = 0.162 P = 0.009) at the distal radius, but not at the tibia. Age and PTH levels were potential confounding variables, but in the multiple linear regressions only BMI (95% CI: 0.11–4.16; P < 0.01), 25(OH)D (95% CI: −0.007 to 1.70; P = 0.05) and CTX (95% CI: −149.04 to 21.80; P < 0.01) predicted Dcomp, while BMI (95% CI: 1.13–4.18; P < 0.01) and 25(OH)D (95% CI: 0.24–1.52; P < 0.01) predicted D100. NonVFs predominated in patients with 25(OH)D <20 ng/mL (P = 0.013). Logistic regression analysis showed a decrease in the likelihood of presenting grade 2–3 VFs/NonVFs for every increase in 25(OH)D (OR = 0.962, 95% CI: 0.940–0.984; P = 0.001), BMI (OR = 0.932, 95% CI: 0.885–0.981; P = 0.007) and D100 at radius (OR = 0.994, 95% CI: 0.990–0.998; P = 0.005). Conclusion In elderly patients with prevalent fractures, vitamin D deficiency was associated with cortical bone loss and severity of fractures.

scholarly journals SAT0169 Influence of vitamin d receptor (vdr) genotype in the bone loss induced by corticosteroid therapy

2001 ◽  
Author(s):  
M Gantes ◽  
A Arteaga ◽  
Y Barrios ◽  
E Uruburu ◽  
I Ferraz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Corticosteroid Therapy ◽  
Vitamin D Receptor

Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss

2018 ◽  
Vol 11 (4) ◽  
pp. 1145-1154 ◽  
Author(s):  
Nima Montazeri-Najafabady ◽  
Younes Ghasemi ◽  
Mohammad Hossein Dabbaghmanesh ◽  
Pedram Talezadeh ◽  
Farhad Koohpeyma ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Cortical Bone Loss ◽  
Supportive Role ◽  
Probiotic Strains

scholarly journals Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

JCI Insight ◽  
2020 ◽  
Vol 5 (19) ◽  
Author(s):  
Ha-Neui Kim ◽  
Jinhu Xiong ◽  
Ryan S. MacLeod ◽  
Srividhya Iyer ◽  
Yuko Fujiwara ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Cortical Bone Loss

Biomechanical Effects of the Nail Entry Zone and Anterior Cortical Bone Loss on the Proximal Tibia

2013 ◽  
Vol 27 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Hassan R. Mir ◽  
Ruxi C. Marinescu ◽  
Haden Janda ◽  
Thomas A. Russell
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Proximal Tibia ◽  
Entry Zone ◽  
Cortical Bone Loss

scholarly journals Simultaneous expression analysis of vitamin D receptor, calcium-sensing receptor, cyclin D1, and PTH in symptomatic primary hyperparathyroidism in Asian Indians

2013 ◽  
Vol 169 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Shweta Varshney ◽  
Sanjay Kumar Bhadada ◽  
Uma Nahar Saikia ◽  
Naresh Sachdeva ◽  
Arunanshu Behera ◽  
...  
Keyword(s):  
Vitamin D ◽  
Primary Hyperparathyroidism ◽  
Cyclin D1 ◽  
Vitamin D Receptor ◽  
Asian Indians ◽  
Parathyroid Tissue ◽  
Fold Change ◽  
Mrna Levels ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

BackgroundTo explore underlying molecular mechanisms in the pathogenesis of symptomatic sporadic primary hyperparathyroidism (PHPT).Materials and methodsForty-one parathyroid adenomas from patients with symptomatic PHPT and ten normal parathyroid glands either from patients with PHPT (n=3) or from euthyroid patients without PHPT during thyroid surgery (n=7) were analyzed for vitamin D receptor (VDR), calcium-sensing receptor (CASR), cyclin D1 (CD1), and parathyroid hormone (PTH) expressions. The protein expressions were assessed semiquantitatively by immunohistochemistry, based on percentage of positive cells and staining intensity, and confirmed by quantitative real-time PCR.ResultsImmunohistochemistry revealed significant reductions in VDR (both nuclear and cytoplasmic) and CASR expressions and significant increases in CD1 and PTH expressions in adenomatous compared with normal parathyroid tissue. Consistent with immunohistochemistry findings, bothVDRandCASRmRNAs were reduced by 0.36- and 0.45-fold change (P<0.001) andCD1andPTHmRNAs were increased by 9.4- and 17.4-fold change respectively (P<0.001) in adenomatous parathyroid tissue.PTHmRNA correlated with plasma PTH (r=0.864;P<0.001), but not with adenoma weight, whileCD1mRNA correlated with adenoma weight (r=0.715;P<0.001). There were no correlations betweenVDRandCASRmRNA levels and serum Ca, plasma intact PTH, or 25-hydroxyvitamin D levels. In addition, there was no relationship between the decreases inVDRandCASRmRNA expressions and the increases inPTHandCD1mRNA expressions.ConclusionsThe expression of both VDR and CASR are reduced in symptomatic PHPT in Asian Indians. In addition,CD1expression was greatly increased and correlated with adenoma weight, implying a potential role for CD1 in adenoma growth and differential clinical expression of PHPT.

Vitamin D Receptor Initiation Codon Polymorphism in Japanese Patients with Graves' Disease

Thyroid ◽  
2000 ◽  
Vol 10 (6) ◽  
pp. 475-480 ◽  
Author(s):  
Yoshiyuki Ban ◽  
Yoshio Ban ◽  
Matsuo Taniyama ◽  
Takashi Katagiri
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Japanese Patients ◽  
Initiation Codon ◽  
Graves Disease
Sign in / Sign up

Export Citation Format

Share Document