scholarly journals The Stability of Truncated Epidermal Growth Factor Receptor mRNA is Higher Than That of the Full-Length Receptor mRNA in Rat Hepatoma Cells.

1997 ◽  
Vol 44 (3) ◽  
pp. 403-408 ◽  
Author(s):  
YUKIO SATOH ◽  
MIKA OOMAE ◽  
YOSHIKO HOSHIKAWA ◽  
MASAO IZAWA ◽  
TAKESHI SAIRENJI ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Hepatoma Cells ◽  
Receptor Mrna ◽  
Epidermal Growth ◽  
The Stability ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

scholarly journals Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression–induced apoptosis in hepatoma cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769502 ◽  
Author(s):  
Kai Liu ◽  
Dongdong Lin ◽  
Yabo Ouyang ◽  
Lijun Pang ◽  
Xianghua Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Hepg2 Cells ◽  
Apoptotic Cell ◽  
Growth Factor Receptor ◽  
Hepatoma Cells ◽  
Epidermal Growth ◽  
Induced Apoptosis

Overexpression of apoptosis-stimulating protein 2 of p53 (ASPP2) induces apoptotic cell death in hepatoma cells (e.g. HepG2 cells) by enhancing the transactivation activity of p53, but long-term ASPP2 overexpression fails to induce more apoptosis since activation of the epidermal growth factor/epidermal growth factor receptor/SOS1 pathway impairs the pro-apoptotic role of ASPP2. In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner. Although amphiregulin initially contributes to ASPP2-induced apoptosis, it eventually impairs the pro-apoptotic function of ASPP2 by activating the epidermal growth factor/epidermal growth factor receptor/SOS1 pathway, leading to apoptosis resistance. Moreover, blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis. Thus, our data elucidate an apoptosis-evasion mechanism in hepatocellular carcinoma and have potential implications for hepatocellular carcinoma therapy.

The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells

2012 ◽  
Vol 319 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Annemarie Losert ◽  
Daniela Lötsch ◽  
Andreas Lackner ◽  
Herwig Koppensteiner ◽  
Barbara Peter-Vörösmarty ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Hepatoma Cells ◽  
Major Vault Protein ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Receptor Inhibition ◽  
Epidermal Growth

Detection of epidermal growth factor receptor mRNA in peripheral blood of cervical cancer patients

2003 ◽  
Vol 89 (3) ◽  
pp. 480-485 ◽  
Author(s):  
Akira Mitsuhashi ◽  
Naotake Tanaka ◽  
Kiyomi Suzuka ◽  
Hideo Matsui ◽  
Katsuyoshi Seki ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Growth Factor Receptor ◽  
Receptor Mrna ◽  
Epidermal Growth
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