scholarly journals Prolactin Causes the Dissociation of Prolactin from Plasma Membrane Receptor in Lactating Mouse Mammary Cell: Action of High Prolactin Concentration.

1996 ◽  
Vol 43 (1) ◽  
pp. 93-100
Author(s):  
SENKITI SAKAI
Keyword(s):  
Plasma Membrane ◽  
Membrane Receptor ◽  
Mammary Cell ◽  
Plasma Membrane Receptor

scholarly journals Plasma Membrane Receptor Complexes

2008 ◽  
Vol 147 (4) ◽  
pp. 1560-1564 ◽  
Author(s):  
José Aker ◽  
Sacco C. de Vries
Keyword(s):  
Plasma Membrane ◽  
Membrane Receptor ◽  
Receptor Complexes ◽  
Plasma Membrane Receptor

scholarly journals Anthrax toxin rafts into cells

2003 ◽  
Vol 160 (3) ◽  
pp. 295-296 ◽  
Author(s):  
Teymuras Kurzchalia
Keyword(s):  
Plasma Membrane ◽  
Lipid Rafts ◽  
Membrane Receptor ◽  
Anthrax Toxin ◽  
Plasma Membrane Receptor ◽  
Toxin Uptake ◽  
Dependent Pathway

Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin-dependent pathway.

scholarly journals Comment on "A G Protein Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid"

Science ◽  
2007 ◽  
Vol 318 (5852) ◽  
pp. 914c-914c ◽  
Author(s):  
C. A. Johnston ◽  
B. R. Temple ◽  
J.-G. Chen ◽  
Y. Gao ◽  
E. N. Moriyama ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Abscisic Acid ◽  
G Protein ◽  
Plant Hormone ◽  
Membrane Receptor ◽  
G Protein Coupled Receptor ◽  
Plasma Membrane Receptor ◽  
G Protein Coupled

scholarly journals Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3

2021 ◽  
Vol 9 ◽  
Author(s):  
Elena Candelotti ◽  
Roberto De Luca ◽  
Roberto Megna ◽  
Mariangela Maiolo ◽  
Paolo De Vito ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Plasma Membrane ◽  
Cell Migration ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Integrin Αvβ3 ◽  
Membrane Receptor ◽  
Αvβ3 Integrin ◽  
Plasma Membrane Receptor ◽  
Cell Migration And Proliferation

Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for insulin-like growth factor-1 (IGF-1). Previous data from our laboratory show a crosstalk between thyroid hormones and IGF-1 because thyroid hormones inhibit the IGF-1-stimulated glucose uptake and cell proliferation in L-6 myoblasts, and the effects are mediated by integrin αvβ3. IGF-1 also behaves as a chemokine, being an important factor for tissue regeneration after damage. In the present study, using THP-1 human leukemic monocytes, expressing αvβ3 integrin in their cell membrane, we focused on the crosstalk between thyroid hormones and either IGF-1 or monocyte chemoattractant protein-1 (MCP-1), studying cell migration and proliferation stimulated by the two chemokines, and the role of αvβ3 integrin, using inhibitors of αvβ3 integrin and downstream pathways. Our results show that IGF-1 is a potent chemoattractant in THP-1 monocytes, stimulating cell migration, and thyroid hormone inhibits the effect through αvβ3 integrin. Thyroid hormone also inhibits IGF-1-stimulated cell proliferation through αvβ3 integrin, an example of a crosstalk between genomic and non-genomic effects. We also studied the effects of thyroid hormone on cell migration and proliferation induced by MCP-1, together with the pathways involved, by a pharmacological approach and docking simulation. Our findings show a different downstream signaling for IGF-1 and MCP-1 in THP-1 monocytes mediated by the plasma membrane receptor of thyroid hormones, integrin αvβ3.

Some properties of the plasma membrane receptor for granulocyte colony-stimulating factor

1990 ◽  
Vol 18 (2) ◽  
pp. 290-290
Author(s):  
COLIN P. McGUCKIN ◽  
NIAMH D. CUNNINGHAM ◽  
MICHELLE McCABE ◽  
CLAIRE ADAMS ◽  
WILLIAM S. GILMORE
Keyword(s):  
Plasma Membrane ◽  
Membrane Receptor ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Plasma Membrane Receptor ◽  
Stimulating Factor
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