scholarly journals Human Corticotropin-Releasing Hormone (hCRH) Test: Sex and Age Differences in Plasma ACTH and Cortisol Responses and their Reproducibility in Healthy Adults.

1993 ◽  
Vol 40 (5) ◽  
pp. 571-579 ◽  
Author(s):  
KOSHI TANAKA ◽  
NAOKATA SHIMIZU ◽  
HIROO IMURA ◽  
JUNICHI FUKATA ◽  
ITSURO HIBI ◽  
...  
Keyword(s):  
Age Differences ◽  
Healthy Adults ◽  
Corticotropin Releasing Hormone ◽  
Plasma Acth ◽  
Releasing Hormone ◽  
Cortisol Responses ◽  
Sex And Age Differences

Schizotypal Personality in Healthy Adults Is Related to Blunted Cortisol Responses to the Combined Dexamethasone/ Corticotropin-Releasing Hormone Test

2011 ◽  
Vol 63 (4) ◽  
pp. 232-241 ◽  
Author(s):  
Hiroaki Hori ◽  
Toshiya Teraishi ◽  
Yuji Ozeki ◽  
Kotaro Hattori ◽  
Daimei Sasayama ◽  
...  
Keyword(s):  
Healthy Adults ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Schizotypal Personality ◽  
Cortisol Responses

Consistent Reduction of ACTH responses to stimulation with CRH, Vasopressin and Hypoglycaemia in Patients with Major Depression

1989 ◽  
Vol 155 (4) ◽  
pp. 468-478 ◽  
Author(s):  
Roger G. Kathol ◽  
Richard S. Jaeckle ◽  
Juan F. Lopez ◽  
William H. Meller
Keyword(s):  
Major Depression ◽  
Hpa Axis ◽  
Negative Correlation ◽  
Arginine Vasopressin ◽  
Corticotropin Releasing Hormone ◽  
Hypothalamic Pituitary Adrenal ◽  
Releasing Hormone ◽  
Control Subjects ◽  
Basal Cortisol ◽  
Cortisol Responses

Eleven patients with major depression and 12 control subjects were administered corticotropin-releasing hormone (CRH), aqueous arginine vasopressin (AVP), and insulin hypoglycaemia (IH) to test for differences in hypothalamic–pituitary–adrenal (HPA) axis function. Patients with major depression demonstrated lower ACTH responses to CRH when compared with controls, and a trend toward such after administration of AVP. Despite lower ACTH responses in patients with depression, there were no differences in Cortisol responses to these stimuli. In the CRH and AVP tests, there was no correlation between the basal Cortisol and ACTH responses in either controls or patients, but in the IH test there was a negative correlation between these responses for both groups. The ACTH responses to CRH and AVP were positively correlated in controls and patients. Cortisol responses to all three provocative stimuli were positively correlated in both subject groups. These findings are consistent with the hypothesis that hypothalamic or supra-hypothalamic overactivity may be involved in the development of HPA-axis abnormalities in patients with depression.

Lack of effect of desmopressin on ACTH and cortisol responses to ovine corticotropin-releasing hormone in anorexia nervosa

1996 ◽  
Vol 26 (10) ◽  
pp. 879-883 ◽  
Author(s):  
L. FOPPIANI ◽  
P. SESSAREGO ◽  
S. VALENTI ◽  
M. R. FALIVENE ◽  
C. M. CUTTIC ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Cortisol Responses

scholarly journals 28 Sex- and age-differences in native t1 relaxation times in healthy adults at 1.5 and 3.0 tesla

Heart ◽  
2015 ◽  
Vol 101 (Suppl 2) ◽  
pp. A16.1-A16
Author(s):  
S Rauhalammi ◽  
P Hall Barrientos ◽  
D Carrick ◽  
C McComb ◽  
K Mangion ◽  
...  
Keyword(s):  
Age Differences ◽  
Relaxation Times ◽  
Healthy Adults ◽  
3.0 Tesla ◽  
Native T1 ◽  
T1 Relaxation ◽  
Sex And Age Differences

Human corticotropin releasing hormone test performance in the differential diagnosis between Cushing's disease and pseudo-Cushing state is enhanced by combined ACTH and cortisol analysis

2009 ◽  
Vol 160 (6) ◽  
pp. 891-898 ◽  
Author(s):  
Giorgio Arnaldi ◽  
Giacomo Tirabassi ◽  
Roberta Papa ◽  
Giorgio Furlani ◽  
Laura Trementino ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Cushing’S Disease ◽  
Peak Plasma ◽  
Serum Cortisol ◽  
Cushing's Syndrome ◽  
Peak Serum ◽  
Cushing's Disease ◽  
Corticotropin Releasing Hormone ◽  
Plasma Acth ◽  
Releasing Hormone

ObjectiveCorticotropin releasing hormone (CRH) test does not reliably distinguish Cushing's disease (CD) from normality or pseudo-Cushing state (PC). We assessed whether this could be achieved with a novel approach while preserving the ability of the test to distinguish CD from ectopic ACTH syndrome (EAS).DesignRetrospective/prospective study.Subjects and methodsWe studied 51 subjects with CD, 7 with EAS, 26 with PC, and 31 controls (CT). Human CRH (hCRH) test was performed at 0830 h by measuring plasma ACTH and serum cortisol at −15, 0, 15, 30, 45, 60, 90, and 120 min.ResultsThe area under the curve–ACTH exhibited a significant negative correlation with baseline serum cortisol in CT and PC, but not in CD or EAS patients. ACTH response to hCRH was blunted in PC compared with CT, whereas peak serum cortisol was higher in PC than in CT subjects. These findings suggested that ACTH-dependent Cushing's syndrome can be diagnosed by the presence of two hCRH test parameters and excluded if either or both are absent. Application of i) basal serum cortisol >12 μg/dl and peak plasma ACTH >54 pg/ml, or ii) peak serum cortisol >21 μg/dl and peak plasma ACTH >45 pg/ml, had 91.3% (95% confidence intervals (CI) 81–97.1) and 94.8% (CI 85.6–98.9) sensitivity and 98.2% (CI 90.6–99.9) and 91.2% (CI 80.7–97) specificity respectively, in diagnosing ACTH-dependent Cushing's syndrome. The >14% serum cortisol increase from mean baseline values to the mean of 15 and 30 min values in patients who were positive for the test completely discriminated between CD and EAS.ConclusionsSimultaneous plasma ACTH and serum cortisol analysis enables the hCRH test to distinguish CD from PC and from normality, while preserving its ability to discriminate CD from EAS.

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