Screening of novel epitopes in Klebsiella pneumoniae, as target for vaccine design

Laila H. El Sayed; Medhat Haroun; Ahmed A. Hussein; El Sayed H. El Ashry; Tarek A. Ahmad

doi:10.1504/ijis.2012.051235

Screening of novel epitopes in Klebsiella pneumoniae, as target for vaccine design

International Journal of Immunological Studies ◽

10.1504/ijis.2012.051235 ◽

2012 ◽

Vol 1 (4) ◽

pp. 336 ◽

Cited By ~ 1

Author(s):

Laila H. El Sayed ◽

Medhat Haroun ◽

Ahmed A. Hussein ◽

El Sayed H. El Ashry ◽

Tarek A. Ahmad

Keyword(s):

Klebsiella Pneumoniae ◽

Vaccine Design

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Impact of branching on the conformational heterogeneity of the lipopolysaccharide from Klebsiella pneumoniae: Implications for vaccine design

Carbohydrate Research ◽

10.1016/j.carres.2019.02.003 ◽

2019 ◽

Vol 475 ◽

pp. 39-47 ◽

Cited By ~ 2

Author(s):

Asaminew H. Aytenfisu ◽

Raphael Simon ◽

Alexander D. MacKerell

Keyword(s):

Klebsiella Pneumoniae ◽

Vaccine Design ◽

Conformational Heterogeneity

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D-galactan II is an immunodominant antigen in O1 lipopolysaccharide and affects virulence in Klebsiella pneumoniae: implication in vaccine design

Frontiers in Microbiology ◽

10.3389/fmicb.2014.00608 ◽

2014 ◽

Vol 5 ◽

Cited By ~ 16

Author(s):

Pei-Fang Hsieh ◽

Meng-Chuan Wu ◽

Feng-Ling Yang ◽

Chun-Tang Chen ◽

Tzu-Chi Lou ◽

...

Keyword(s):

Klebsiella Pneumoniae ◽

Vaccine Design ◽

Immunodominant Antigen

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The structure of the core region of the lipopolysaccharide from Klebsiella pneumoniae O3 3-Deoxy-alpha-D-manno-octulosonic acid (alpha-Kdo) residue in the outer part of the core, a common structural element of Klebsiella pneumoniae O1, O2, O3, O4, O5, O8, and O12 lipopolysaccharides

European Journal of Biochemistry ◽

10.1046/j.1432-1033.2001.02047.x ◽

2001 ◽

Vol 268 (6) ◽

pp. 1722-1729 ◽

Cited By ~ 3

Author(s):

Evgeny Vinogradov ◽

Maciej Cedzynski ◽

Andrzej Ziolkowski ◽

Anna Swierzko

Keyword(s):

Klebsiella Pneumoniae ◽

Outer Part ◽

Core Region ◽

Structural Element ◽

The Core

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Is the antigenic nonapeptide of the HSP60 of Klebsiella pneumoniae the triggering factor in ankylosing spondylitis?

Immunology Letters ◽

10.1016/s0165-2478(97)88073-x ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 306

Author(s):

E García-Latorre

Keyword(s):

Ankylosing Spondylitis ◽

Klebsiella Pneumoniae ◽

Triggering Factor

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Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642520 ◽

1994 ◽

Vol 71 (06) ◽

pp. 768-772 ◽

Cited By ~ 14

Author(s):

Gerhard Dickneite ◽

Jörg Czech

Keyword(s):

Septic Shock ◽

Klebsiella Pneumoniae ◽

Organ Failure ◽

Therapeutic Effect ◽

Disseminated Intravascular Coagulation ◽

Post Infection ◽

Thrombin Inhibitor ◽

Bolus Administration ◽

Bacterial Burden ◽

Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

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