Non-Newtonian blood flow and coupled blood-wall oxygen mass transport in a 180° curved artery

Author(s):  
Mohammad Amin Raoufi ◽  
Hamid Niazmand ◽  
Mahdi Pourramezan
1999 ◽  
Vol 65 (632) ◽  
pp. 1362-1369
Author(s):  
Yoshiyuki WAKI ◽  
Takuji ISHIKAWA ◽  
Shuzo OSHIMA ◽  
Ryuichiro YAMANE ◽  
Motoharu HASEGAWA

Angiology ◽  
2016 ◽  
Vol 68 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Antonis I. Sakellarios ◽  
Paschalis Bizopoulos ◽  
Michail I. Papafaklis ◽  
Lambros Athanasiou ◽  
Themis Exarchos ◽  
...  

Carotid atherosclerosis may lead to devastating clinical outcomes such as stroke. Data on the value of local factors in predicting progression in carotid atherosclerosis are limited. Our aim was to investigate the association of local endothelial shear stress (ESS) and low-density lipoprotein (LDL) accumulation with the natural history of atherosclerotic disease using a series of 3 time points of human magnetic resonance data. Three-dimensional lumen/wall reconstruction was performed in 12 carotids, and blood flow and LDL mass transport modeling were performed. Our results showed that an increase in plaque thickness and a decrease in lumen size were associated with low ESS and high LDL accumulation in the arterial wall. Low ESS (odds ratio [OR]: 2.99; 95% confidence interval [CI]: 2.31-3.88; P < .001 vs higher ESS) and high LDL concentration (OR: 3.26; 95% CI: 2.44-4.36; P < .001 vs higher LDL concentration) were significantly associated with substantial local plaque growth. Low ESS and high LDL accumulation both presented a diagnostic accuracy of 67% for predicting plaque growth regions. Modeling of blood flow and LDL mass transport show promise in predicting progression of carotid atherosclerosis.


1999 ◽  
Vol 42 (3) ◽  
pp. 680-688 ◽  
Author(s):  
Takuji ISHIKAWA ◽  
Shuzo OSHIMA ◽  
Ryuichiro YAMANE

2019 ◽  
Vol 16 (03) ◽  
pp. 1842003 ◽  
Author(s):  
Biyue Liu ◽  
Dalin Tang

Computer simulations of the blood flow through right coronary arteries with two stenoses in the same arterial segment are carried out to investigate the interactions of serial stenoses, especially the effect of the distal stenosis. Various mathematical models are developed by varying the location of the distal stenosis. The numerical results show that the variation of the distal stenosis has significant impact on coronary hemodynamics, such as the pressure drop, flow shifting, wall shear stress and flow separation. Our simulations demonstrate that the distal stenosis has insignificant effect on the disturbed flow pattern in the regions of upstream and across the proximal stenosis. In a curved artery segment with two moderate stenoses of the same size, the distal stenosis causes a larger pressure drop and a more disturbed flow field in the poststenotic region than the proximal stenosis does. A distal stenosis located at a further downstream position causes a larger pressure drop and a stronger reverse flow.


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