scholarly journals Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI

2020 ◽  
Vol 45 (1) ◽  
pp. 55-68 ◽  
Author(s):  
Jiaying Gong ◽  
Junjing Wang ◽  
Xiaomei Luo ◽  
Guanmao Chen ◽  
Huiyuan Huang ◽  
...  
Keyword(s):  
Functional Mri ◽  
Resting State ◽  
Brain Activity ◽  
Meta Analysis ◽  
Chronic Schizophrenia ◽  
First Episode ◽  
Regional Brain ◽  
Regional Brain Activity

scholarly journals Evaluation of spontaneous regional brain activity in weight-recovered anorexia nervosa

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Maria Seidel ◽  
Daniel Geisler ◽  
Viola Borchardt ◽  
Joseph A. King ◽  
Fabio Bernardoni ◽  
...  
Keyword(s):  
Resting State ◽  
Grey Matter ◽  
Brain Activity ◽  
Low Frequency ◽  
Regional Homogeneity ◽  
Degree Centrality ◽  
Mean Square ◽  
Regional Brain ◽  
Cortical Grey Matter ◽  
Regional Brain Activity

AbstractWhereas research using structural magnetic resonance imaging (sMRI) reports sizable grey matter reductions in patients suffering from acute anorexia nervosa (AN) to be largely reversible already after short-term weight gain, many task-based and resting-state functional connectivity (RSFC) studies suggest persistent brain alterations even after long-term weight rehabilitation. First investigations into spontaneous regional brain activity using voxel-wise resting-state measures found widespread abnormalities in acute AN, but no studies have compared intrinsic brain activity properties in weight-recovered individuals with a history of AN (recAN) with healthy controls (HCs). SMRI and RSFC data were analysed from a sample of 130 female volunteers: 65 recAN and 65 pairwise age-matched HC. Cortical grey matter thickness was assessed using FreeSurfer software. Fractional amplitude of low-frequency fluctuations (fALFFs), mean-square successive difference (MSSD), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VHMC), and degree centrality (DC) were calculated. SMRI and RSFC data were analysed from a sample of 130 female volunteers: 65 recAN and 65 pairwise age-matched HCs. Cortical grey matter thickness was assessed using FreeSurfer software. Fractional amplitude of low-frequency fluctuations (fALFF), mean-square successive difference (MSSD), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VHMC), and degree centrality (DC) were calculated. Abnormal regional homogeneity found in acute AN seems to normalize in recAN, supporting assumptions of a state rather than a trait marker. Aberrant fALFF values in the cerebellum and the infertior temporal gyrus could possibly hint towards trait factors or a scar (the latter, e.g., from prolonged periods of undernutrition), warranting further longitudinal research.

scholarly journals EEG Microstate Differences in Medicated vs. Medication-Naïve First-Episode Psychosis Patients

2020 ◽  
Vol 11 ◽  
Author(s):  
Amatya J. Mackintosh ◽  
Stefan Borgwardt ◽  
Erich Studerus ◽  
Anita Riecher-Rössler ◽  
Renate de Bock ◽  
...  
Keyword(s):  
Antipsychotic Medication ◽  
Resting State ◽  
Psychotic Disorders ◽  
Brain Activity ◽  
Treatment Strategies ◽  
Chronic Schizophrenia ◽  
First Episode ◽  
Medication Effects ◽  
Class B ◽  
Eeg Recordings

There has been considerable interest in the role of synchronous brain activity abnormalities in the pathophysiology of psychotic disorders and their relevance for treatment; one index of such activity are EEG resting-state microstates. These reflect electric field configurations of the brain that persist over 60–120 ms time periods. A set of quasi-stable microstates classes A, B, C, and D have been repeatedly identified across healthy participants. Changes in microstate parameters coverage, duration and occurrence have been found in medication-naïve as well as medicated patients with psychotic disorders compared to healthy controls. However, to date, only two studies have directly compared antipsychotic medication effects on EEG microstates either pre- vs. post-treatment or between medicated and unmedicated chronic schizophrenia patients. The aim of this study was therefore to directly compare EEG resting-state microstates between medicated and medication-naïve (untreated) first-episode (FEP) psychosis patients (mFEP vs. uFEP). We used 19-channel clinical EEG recordings to compare temporal parameters of four prototypical microstate classes (A–D) within an overall sample of 47 patients (mFEP n = 17; uFEP n = 30). The results demonstrated significant decreases of microstate class A and significant increases of microstate class B in mFEP compared to uFEP. No significant differences between groups were found for microstate classes C and D. Further studies are needed to replicate these results in longitudinal designs that assess antipsychotic medication effects on neural networks at the onset of the disorder and over time during illness progression. As treatment response and compliance in FEP patients are relatively low, such studies could contribute to better understand treatment outcomes and ultimately improve treatment strategies.

Regional brain activity during jaw clenching with natural teeth and with occlusal splints: a preliminary functional MRI study

CRANIO® ◽  
2016 ◽  
Vol 34 (3) ◽  
pp. 188-194 ◽  
Author(s):  
Yoshiko Ariji ◽  
Shuji Koyama ◽  
Shigemitsu Sakuma ◽  
Miwa Nakayama ◽  
Eiichiro Ariji
Keyword(s):  
Functional Mri ◽  
Brain Activity ◽  
Occlusal Splints ◽  
Regional Brain ◽  
Natural Teeth ◽  
Regional Brain Activity ◽  
Mri Study
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