scholarly journals Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness

2017 ◽  
Vol 42 (6) ◽  
pp. 395-403 ◽  
Author(s):  
Oana Georgiana Rus ◽  
Tim Jonas Reess ◽  
Gerd Wagner ◽  
Michael Zaudig ◽  
Claus Zimmer ◽  
...  
Keyword(s):  
Surface Area ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Structural Alterations ◽  
Compulsive Disorder ◽  
Cortical Volume

scholarly journals Gray matter structural alterations in obsessive–compulsive disorder: Relationship to neuropsychological functions

2008 ◽  
Vol 164 (2) ◽  
pp. 123-131 ◽  
Author(s):  
Christopher J. Christian ◽  
Todd Lencz ◽  
Delbert G. Robinson ◽  
Katherine E. Burdick ◽  
Manzar Ashtari ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Gray Matter ◽  
Obsessive Compulsive ◽  
Structural Alterations ◽  
Compulsive Disorder ◽  
Neuropsychological Functions

Surface anatomical profile of the cerebral cortex in obsessive–compulsive disorder: a study of cortical thickness, folding and surface area

2012 ◽  
Vol 43 (5) ◽  
pp. 1081-1091 ◽  
Author(s):  
Q. Fan ◽  
L. Palaniyappan ◽  
L. Tan ◽  
J. Wang ◽  
X. Wang ◽  
...  
Keyword(s):  
Surface Area ◽  
Obsessive Compulsive Disorder ◽  
Cortical Thickness ◽  
Unbiased Estimation ◽  
Grey Matter Volume ◽  
Cortical Surface ◽  
Subcortical Structures ◽  
Obsessive Compulsive ◽  
Whole Brain ◽  
Compulsive Disorder

BackgroundStudying the distribution of anatomical abnormalities over the entire cortical surface can help to identify key neural circuits implicated in generating symptoms of neuropsychiatric disorders. There is a significant inconsistency among studies investigating the neuroanatomy of obsessive–compulsive disorder (OCD) because of the confounding influence of co-morbid depression and medication use and the lack of unbiased estimation of whole-brain morphometric changes. It is also unknown whether the distinct surface anatomical properties of thickness, surface area and gyrification, which collectively contribute to grey matter volume (GMV), are independently affected in OCD.MethodThe cortical maps of thickness, gyrification and surface areal change were acquired from 23 unmedicated OCD patients and 20 healthy controls using an unbiased whole-brain surface-based morphometric (SBM) method to detect regional changes in OCD. Subcortical structures were not assessed in this study.ResultsPatients showed a significant increase in the right inferior parietal cortical thickness. Significant increases in gyrification were also noted in the left insula, left middle frontal and left lateral occipital regions extending to the precuneus and right supramarginal gyrus in OCD. Areal contraction/expansion maps revealed no significant regional differences between the patients and controls. In patients, gyrification of the insula significantly predicted the symptom severity measured using Yale–Brown Obsessive–Compulsive Scale (YBOCS).ConclusionsAn alteration in the cortical surface anatomy is an important feature of OCD seen in unmedicated samples that relates to the severity of the illness. The results underscore the presence of a neurodevelopmental aberration underlying the pathophysiology of OCD.

scholarly journals Brain Structural Alterations in Obsessive-Compulsive Disorder Patients with Autogenous and Reactive Obsessions

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75273 ◽  
Author(s):  
Marta Subirà ◽  
Pino Alonso ◽  
Cinto Segalàs ◽  
Eva Real ◽  
Clara López-Solà ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Structural Alterations ◽  
Compulsive Disorder
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