scholarly journals Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder

2017 ◽  
Vol 42 (6) ◽  
pp. 404-413 ◽  
Author(s):  
Fiona D. Zeeb ◽  
Zhaoxia Li ◽  
Daniel C. Fisher ◽  
Martin H. Zack ◽  
Paul J. Fletcher
Keyword(s):  
Decision Making ◽  
Gambling Disorder ◽  
Male Rats ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Behavioural Sensitization

scholarly journals Risk-based Decision Making in Rats: Modulation by Sex and Amphetamine

2020 ◽  
Author(s):  
Dannia Islas-Preciado ◽  
Steven R. Wainwright ◽  
Julia Sniegocki ◽  
Stephane E. Lieblich ◽  
Shunya Yagi ◽  
...  
Keyword(s):  
Decision Making ◽  
Sex Differences ◽  
Gonadal Hormones ◽  
Risky Choice ◽  
Female Rats ◽  
Male Rats ◽  
Risky Decision Making ◽  
Risky Decision ◽  
17Β Estradiol ◽  
Males And Females

AbstractDecision-making is a complex process essential to daily adaptation in many species. Risk is an inherent aspect of decision-making and it is influenced by gonadal hormones. Testosterone and 17β-estradiol may modulate decision making and impact the mesocorticolimbic dopamine pathway. Here, we explored sex differences, the effect of gonadal hormones and the dopamine agonist amphetamine on risk-based decision making. Intact or gonadectomised (GDX) male and female rats underwent to a probabilistic discounting task. High and low doses of testosterone propionate (1.0 or 0.2 mg) and 17β-estradiol benzoate (0.3 μg) were administered to assess acute effects on risk-based decision making. After 3-days of washout period, intact and GDX rats received high or low (0.5 or 0.125 mg/kg) doses of amphetamine and re-tested in the probabilistic discounting task. Under baseline conditions, males made more risky choices during probability discounting compared to female rats, particularly in the lower probability blocks, but GDX did not influence risky choice. The high, but not the low dose, of testosterone modestly reduced risky decision making in GDX male rats. Conversely, 17β-estradiol had no significant effect on risky choice regardless of GDX status in either sex. Lastly, a higher dose of amphetamine increased risky decision making in both intact males and females, but had no effect in GDX rats. These findings demonstrated sex differences in risk-based decision making, with males showing a stronger bias towards larger, uncertain rewards. GDX status influenced the effects of amphetamine, suggesting different dopaminergic regulation in risk-based choices among males and females.

scholarly journals Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder

2018 ◽  
Vol 18 (2) ◽  
pp. 269-285 ◽  
Author(s):  
Iris M. Balodis ◽  
Jakob Linnet ◽  
Fiza Arshad ◽  
Patrick D. Worhunsky ◽  
Michael C. Stevens ◽  
...  
Keyword(s):  
Decision Making ◽  
Gambling Disorder ◽  
Neural Processing ◽  
Risky Decision Making ◽  
Risky Decision

scholarly journals Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder

2021 ◽  
pp. 97-113
Author(s):  
Iris M. Balodis ◽  
Jakob Linnet ◽  
Fiza Arshad ◽  
Patrick D. Worhunsky ◽  
Michael C. Stevens ◽  
...  
Keyword(s):  
Decision Making ◽  
Gambling Disorder ◽  
Neural Processing ◽  
Risky Decision Making ◽  
Risky Decision

scholarly journals Dopamine and Risky Decision-Making in Gambling Disorder

eNeuro ◽  
2020 ◽  
Vol 7 (3) ◽  
pp. ENEURO.0461-19.2020 ◽  
Author(s):  
Jan Peters ◽  
Taylor Vega ◽  
Dawn Weinstein ◽  
Jennifer Mitchell ◽  
Andrew Kayser
Keyword(s):  
Decision Making ◽  
Gambling Disorder ◽  
Risky Decision Making ◽  
Risky Decision

Planning and Search in Multi-Stage Risky Decision Making

2011 ◽  
Author(s):  
Jared Hotaling ◽  
Jerry Busemeyer ◽  
Richard Shiffrin
Keyword(s):  
Decision Making ◽  
Risky Decision Making ◽  
Risky Decision ◽  
Multi Stage
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