scholarly journals Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition

2017 ◽  
Vol 42 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Dennis van der Meer ◽  
Catharina A. Hartman ◽  
Daan van Rooij ◽  
Barbara Franke ◽  
Dirk J. Heslenfeld ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Response Inhibition ◽  
Attention Deficit ◽  
Neural Correlates ◽  
Hyperactivity Disorder ◽  
Dopaminergic Genes

scholarly journals Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments

2021 ◽  
pp. 1-9 ◽  
Author(s):  
Isabella Vainieri ◽  
Joanna Martin ◽  
Anna-Sophie Rommel ◽  
Philip Asherson ◽  
Tobias Banaschewski ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Reaction Time ◽  
Response Inhibition ◽  
Attention Deficit ◽  
Random Effect ◽  
Risk Scores ◽  
Time Variability ◽  
Attention Regulation ◽  
Hyperactivity Disorder ◽  
Meta Analyses

Abstract Background A recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE). Methods The discovery GWAS included 19 099 ADHD cases and 34 194 control participants. The combined target sample included 845 people with ADHD (age: 8–40 years). RTV and CE were available from reaction time and response inhibition tasks. ADHD PRS were calculated from the GWAS using a leave-one-study-out approach. Regression analyses were run to investigate whether ADHD PRS were associated with CE and RTV. Results across sites were combined via random effect meta-analyses. Results When combining the studies in meta-analyses, results were significant for RTV (R2 = 0.011, β = 0.088, p = 0.02) but not for CE (R2 = 0.011, β = 0.013, p = 0.732). No significant association was found between ADHD PRS and RTV or CE in any sample individually (p > 0.10). Conclusions We detected a significant association between PRS for ADHD and RTV (but not CE) in individuals with ADHD, suggesting that common genetic risk variants for ADHD influence attention regulation.

Neural correlates of visuospatial working memory in attention-deficit/hyperactivity disorder and healthy controls

2015 ◽  
Vol 233 (2) ◽  
pp. 233-242 ◽  
Author(s):  
Hanneke van Ewijk ◽  
Wouter D. Weeda ◽  
Dirk J. Heslenfeld ◽  
Marjolein Luman ◽  
Catharina A. Hartman ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Working Memory ◽  
Attention Deficit ◽  
Neural Correlates ◽  
Healthy Controls ◽  
Visuospatial Working Memory ◽  
Hyperactivity Disorder
Sign in / Sign up

Export Citation Format

Share Document