scholarly journals Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics

2014 ◽  
Vol 39 (6) ◽  
pp. 407-416 ◽  
Author(s):  
Natalie Matosin ◽  
Francesca Fernandez-Enright ◽  
Elisabeth Frank ◽  
Chao Deng ◽  
Jenny Wong ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anterior Cingulate Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Metabotropic Glutamate ◽  
Nonpsychotic Depression

Inhibition of Metabotropic Glutamate Receptor Subtype 1 Alters the Excitability of the Commissural Pyramidal Neuron in the Rat Anterior Cingulate Cortex after Chronic Constriction Injury to the Sciatic Nerve

2017 ◽  
Vol 127 (3) ◽  
pp. 515-533 ◽  
Author(s):  
Shi-Hao Gao ◽  
Lin-Lin Shen ◽  
Hui-Zhong Wen ◽  
Yan-Dong Zhao ◽  
Huai-Zhen Ruan
Keyword(s):  
Potassium Channel ◽  
Anterior Cingulate Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Chronic Constriction Injury ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Receptor Subtype ◽  
Voltage Gated ◽  
Metabotropic Glutamate

Abstract Background Inhibition of the metabotropic glutamate receptor subtype 1 in the anterior cingulate cortex has an analgesic effect during sustained nociceptive hypersensitivity. However, the specific changes in different subtypes of anterior cingulate cortex layer 5 pyramidal neurons, as well as the distinct effect of metabotropic glutamate receptor subtype 1 inhibition on different neuronal subtypes, have not been well studied. Methods Retrograde labeling combined with immunofluorescence, whole cell clamp recording, and behavioral tests combined with RNA interference were performed in a rat model of chronic constriction injury to the sciatic nerve. Results Commissural layer 5 pyramidal neurons (projecting to the contralateral cortex) existed in the anterior cingulate cortex. The voltage-gated potassium channel subunit 2–mediated current in these neurons were substantially reduced after chronic constriction injury (current densities at +30 mV for the sham, and chronic constriction injury neurons were [mean ± SD] 10.22 ± 3.42 pA/pF vs. 5.58 ± 2.71 pA/pF, respectively; n = 11; P < 0.01), which increased the spike width and fast afterhyperpolarization potential, resulting in hyperexcitability. Inhibition of metabotropic glutamate receptor subtype 1 alleviated the down-regulation of voltage-gated potassium channel subunit 2 currents (current density increased by 8.11 ± 3.22 pA/pF; n = 7; P < 0.01). Furthermore, knockdown of voltage-gated potassium channel subunit 2 current in the commissural neurons attenuated the analgesic effect of metabotropic glutamate receptor subtype 1 inhibition (n = 6 rats; P < 0.05). Conclusions The effect of metabotropic glutamate receptor subtype 1 inhibition on commissural anterior cingulate cortex layer 5 pyramidal neurons is likely different with the modification of previously studied hyperpolarization-activated/cyclic nucleotide-gated channel-dependent neurons but relies on the alteration of voltage-gated potassium channel subunit 2 currents. These results will contribute to a better understanding of the therapeutic role of metabotropic glutamate receptor subtype 1 in chronic pain.

scholarly journals Group II metabotropic glutamate receptor expressing neurons in anterior cingulate cortex become sensitized after inflammatory and neuropathic pain

2020 ◽  
Vol 16 ◽  
pp. 174480692091533
Author(s):  
Sisi Chen ◽  
Feni Kadakia ◽  
Steve Davidson
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Glutamate Receptor ◽  
Inflammatory Pain ◽  
Metabotropic Glutamate Receptor ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Receptor Subtype ◽  
Metabotropic Glutamate ◽  
Group Ii

The anterior cingulate cortex is a limbic region associated with the emotional processing of pain. How neuropathic and inflammatory pain models alter the neurophysiology of specific subsets of neurons in the anterior cingulate cortex remains incompletely understood. Here, we used a GRM2Cre:tdtomato reporter mouse line to identify a population of pyramidal neurons selectively localized to layer II/III of the murine anterior cingulate cortex. GRM2encodes the group II metabotropic glutamate receptor subtype 2 which possesses analgesic properties in mouse and human models, although its function in the anterior cingulate cortex is not known. The majority of GRM2-tdtomato anterior cingulate cortex neurons expressed GRM2gene product in situ but did not overlap with cortical markers of local inhibitory interneurons, parvalbumin or somatostatin. Physiological properties of GRM2-tdtomato anterior cingulate cortex neurons were investigated using whole-cell patch clamp techniques in slice from animals with neuropathic or inflammatory pain, and controls. After hind-paw injection of Complete Freund’s Adjuvant or chronic constriction injury, GRM2-tdtomato anterior cingulate cortex neurons exhibited enhanced excitability as measured by an increase in the number of evoked action potentials and a decreased rheobase. This hyperexcitability was reversed pharmacologically by bath application of the metabotropic glutamate receptor subtype 2 agonist (2R, 4R)-4-Aminopyrrolidine-2,4-dicarboxylate APDC (1 µM) in both inflammatory and neuropathic models. We conclude that layer II/III pyramidal GRM2-tdtomato anterior cingulate cortex neurons express functional group II metabotropic glutamate receptors and undergo changes to membrane biophysical properties under conditions of inflammatory and neuropathic pain.

In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder

2007 ◽  
Vol 116 (6) ◽  
pp. 467-472 ◽  
Author(s):  
A. Fornito ◽  
G. S. Malhi ◽  
J. Lagopoulos ◽  
B. Ivanovski ◽  
S. J. Wood ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder

2004 ◽  
Vol 55 (6) ◽  
pp. 652-655 ◽  
Author(s):  
Alan J Thomas ◽  
Sue Davis ◽  
I.Nicol Ferrier ◽  
Rajesh N Kalaria ◽  
John T O'Brien
Keyword(s):  
Bipolar Disorder ◽  
Cell Adhesion ◽  
Anterior Cingulate Cortex ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cingulate Cortex ◽  
Anterior Cingulate
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