scholarly journals Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: Mood-congruent memory in male mice?

2013 ◽  
Vol 38 (4) ◽  
pp. 259-268 ◽  
Author(s):  
André Takatsu-Coleman
Keyword(s):  
Social Isolation ◽  
Male Mice ◽  
Short Term ◽  
Mood Congruent Memory

scholarly journals Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-1-25
Author(s):  
Muhammad Imran Khan ◽  
Vahid Nikoui ◽  
Jamal Ahmad ◽  
Bashir Ahmad ◽  
Ahmad-Reza Dehpour
Keyword(s):  
Social Isolation ◽  
Male Mice ◽  
Isolation Stress ◽  
Social Isolation Stress

scholarly journals Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-induced Weight Gain in Male Mice

2020 ◽  
Author(s):  
E. Matthew Morris ◽  
Roberto D. Noland ◽  
Michael E. Ponte ◽  
Michelle L. Montonye ◽  
Julie A. Christianson ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Weight Gain ◽  
Energy Metabolism ◽  
Energy Balance ◽  
Fatty Acid Oxidation ◽  
Positive Energy ◽  
Acid Oxidation ◽  
Male Mice ◽  
Short Term

AbstractCentral integration of peripheral neural signals is one mechanism by which systemic energy homeostasis is regulated. Previous work described increased acute food intake following chemical reduction of hepatic fatty acid oxidation and ATP levels, which was prevented by common hepatic branch vagotomy (HBV). However, possible offsite actions of the chemical compounds confound the precise role of liver energy metabolism. Herein, we used a liver-specific PGC1a heterozygous (LPGC1a) mouse model, with associated reductions in mitochondrial fatty acid oxidation and respiratory capacity, to assess the role of liver energy metabolism in systemic energy homeostasis. LPGC1a male mice have 70% greater high-fat/high-sucrose (HFHS) diet-induced weight gain and 35% greater positive energy balance compared to wildtype (WT) (p<0.05). The greater energy balance was associated with altered feeding behavior and lower activity energy expenditure during HFHS in LPGC1a males. Importantly, no differences in HFHS-induced weight gain or energy metabolism was observed between female WT and LPGC1a mice. WT and LPGC1a mice underwent sham or HBV to assess whether vagal signaling was involved in HFHS-induced weight gain of male LPGC1a mice. HBV increased HFHS-induced weight gain (85%, p<0.05) in male WT, but not LPGC1a mice. As above, sham LPGC1a males gain 70% more weight during short-term HFHS feeding than sham WT (p<0.05). These data demonstrate a sexspecific role of reduced liver energy metabolism in acute diet-induced weight gain, and the need of more nuanced assessment of the role of vagal signaling in short-term diet-induced weight gain.Key Points SummaryReduced liver PGC1a expression results in reduced mitochondrial fatty acid oxidation and respiratory capacity in male mice.Male mice with reduced liver PGC1a expression (LPGC1a) demonstrate greater short-term high-fat/high-sucrose diet-induced weight gain compared to wildtype.Greater positive energy balance during HFHS feeding in male LPGC1a mice is associated with altered food intake patterns and reduced activity energy expenditure.Female LPGC1a mice do not have differences in short-term HFHS-induced body weight gain or energy metabolism compared to wildtype.Disruption of vagal signaling through common hepatic branch vagotomy increases short-term HFHS-induced weight gain in male wildtype mice, but does not alter male LPGC1a weight gain.

scholarly journals Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20955 ◽  
Author(s):  
Xian-cang Ma ◽  
Dong Jiang ◽  
Wen-hui Jiang ◽  
Fen Wang ◽  
Min Jia ◽  
...  
Keyword(s):  
Social Isolation ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Male Mice ◽  
Unpredictable Chronic Mild Stress

scholarly journals Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction

2012 ◽  
Vol 1 (1) ◽  
pp. 3 ◽  
Author(s):  
Kerry M Cameron ◽  
Satomi Miwa ◽  
Cornelia Walker ◽  
Thomas von Zglinicki
Keyword(s):  
Glucose Tolerance ◽  
Dietary Restriction ◽  
Metabolic Memory ◽  
Adult Onset ◽  
Male Mice ◽  
Short Term

Effect of glatiramer acetate on short-term memory impairment induced by lipopolysaccharide in male mice

2016 ◽  
Vol 30 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Fatemeh Mohammadi ◽  
Reza Rahimian ◽  
Nahid Fakhraei ◽  
Seyed Mahdi Rezayat ◽  
Mehrak Javadi-Paydar ◽  
...  
Keyword(s):  
Glatiramer Acetate ◽  
Memory Impairment ◽  
Short Term Memory ◽  
Male Mice ◽  
Short Term ◽  
Term Memory

scholarly journals Short-term changes in behaviors resulting from COVID-19-related social isolation and their influences on mental health

2020 ◽  
Author(s):  
Nestor Asiamah ◽  
Frank Frimpong Opuni ◽  
Edwin Mends-Brew ◽  
Samuel Worlanyo Mensah ◽  
Henry Kofi Mensah ◽  
...  
Keyword(s):  
Mental Health ◽  
Sedentary Behavior ◽  
Social Isolation ◽  
Online Survey ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Negative Influence ◽  
Research Approach ◽  
Short Term ◽  
Social Distancing

Abstract Withdrawing from social activities abruptly can be associated with anxiety and mental health struggles, but this behavior is unavoidable when an infectious disease such as Coronavirus 2019 (COVID-19) is spreading. With many governments taking to social distancing protocols, short-term changes in behaviors and their influences on health are expected. This study adopted a correlational research approach to assess the behavioral outcomes of the social distancing protocols and its influences on mental health. An online survey hosted by Survey Monkey was utilized to collect data from residents of three cities under a COVID-19 mandatory lockdown. A total of 621 surveys were analyzed using descriptive statistics and multiple linear regression analysis, with a sensitivity analysis utilized to select potential covariates for the final regression model. Findings indicate that reduced physical activity time, increased sedentary behavior time, and a change in sexual activity and smoking frequency are some short-term changes in behavior resulting from social isolation during the lockdown. An increase in sedentary behavior made a negative influence on mental health (β = -0.85; t = -46.76, p = 0.000). The only change in behavior that has a positive influence on mental health is substance use. For the most part, changes in behaviors in the short-term attributable to COVID-19 social isolation were associated with lower mental health scores. Our findings imply that COVID-19 social distancing measures should be rolled out alongside public education programs for discouraging unhealthy changes in behaviors.

scholarly journals The effect of oxytocin on the level and monoamines turnover in the brain of isolated mice of highand low-aggressive lines

2017 ◽  
Vol 15 (2) ◽  
pp. 23-30
Author(s):  
Inessa V Karpova ◽  
Evgenii R Bychkov ◽  
Vera V Marysheva ◽  
Vladimir V Mikheyev ◽  
Petr D Shabanov
Keyword(s):  
Cerebral Cortex ◽  
Social Isolation ◽  
Olfactory Tubercle ◽  
Male Mice ◽  
Hydroxyindoleacetic Acid ◽  
Aggressive Male ◽  
Outbred Mice ◽  
Left And Right ◽  
The Right ◽  
The Brain

Objective. In the course of the study, the effect of oxytocin on the behavior and level of monoamines of the brain in aggressive male isolates of the initially low-aggressive C57Bl/6 line with similar indices of highly aggressive white outbred mice was compared. Methods. In experiments on isolated male mice of the low-aggressive C57Bl/6 line and highly aggressive white outbred mice, the effects of oxytocin on the aggressive behavior and the activity of monoaminergic systems of the left and right cerebral hemispheres was investigated. After prolonged social isolation, the male mice, who attacked in the resident-intruder test, were selected for further research. Oxytocin (5 IU/ml, 20μl) was admitrated intranasally. Control animals was treated with saline. With the HPLC-method, in the cerebral cortex, hippocampus, olfactory tubercle and striatum of the left and right sides of the brain the concentrations of dopamine, norepinephrine, serotonin and their metabolites of dioxyphenylacetic, homovaniline and 5-hydroxyindoleacetic acids were measured. Results. Among the male isolates of the C57Bl/6 line, the proportion of aggressive individuals was 56.5%, and among white outbred mice 87.5%. The investigated lines also differed in the attack latency time: aggressive C57Bl/6 mice attacked an average on the 113.1±23.5 second, while in white outbred mice the attack followed on the 35.3±14.7 second (p < 0.01). In the aggressive male isolates of the C57Bl/6 line, which received intranasally saline solution, the content of serotonin and 5-hydroxyindoleacetic acid in the hippocampus was significantly higher on the right. In C57Bl/6, oxytocin reduced the manifestation of aggression caused by prolonged social isolation (p < 0.05), but had no absolute ability to stop this type of behavior. Under its influence, the level of dopamine in the left cortex (p = 0.054), as well as serotonin content in the right hippocampus (p < 0.05) and in the left striatum (p < 0.05) decreased. In addition, the use of oxytocin in C57Bl/6 neutralized the asymmetry of serotonin and 5-hydroxyindoleacetic acid levels in the hippocampus. At the same time there was an asymmetry in the content of dopamine in the cerebral cortex with the predominance of this mediator in the right hemisphere (p < 0.05). In male isolates of highly aggressive white outbred mice, the effect of oxytocin on behavior was not found. However, in these animals oxytocin caused certain changes in monoaminergic systems of the brain. Under the action of oxytocin, the inicial right-sided asymmetry of the level of dopamine metabolites in the striatum and left-sided asymmetry in the level of serotonin in the cortex disappeared. Oxytocin caused an increase in the content of 5-hydroxyacetic acid in the right striatum (p < 0.05) and norepinephrine in the left hippocampus (p < 0.05). In addition, white outbred mice under the influence of oxytocin developed asymmetry with the predominance of norepinephrine in the right olfactory tubercle (p < 0.05). Conclusions. It can be assumed that relatively weak changes in the state of serotonergic and dopaminergic systems against the background of high reactivity of the noradrenergic system are a feature of the reaction of the brain of highly aggressive animals to oxytocin. The data obtained are discussed in terms of the lateralization of neurotransmitter systems responsible for intraspecific aggression caused by prolonged social isolation. (For citation: Karpova IV, Bychkov ER, Marysheva VV, et al. The effect of oxytocin on the level and monoamines turnover in the brain of isolated mice of high- and low-aggressive lines. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):23-30. doi: 10.17816/RCF15223-30).

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