scholarly journals Lung transplantation for acute COVID-19: the Toronto Lung Transplant Program experience

2021 ◽  
Vol 193 (38) ◽  
pp. E1494-E1497
Author(s):  
Jonathan C. Yeung ◽  
Marcelo Cypel ◽  
Cecilia Chaparro ◽  
Shaf Keshavjee
Keyword(s):  
Lung Transplantation ◽  
Lung Transplant ◽  
Transplant Program

Clinical characteristics and epidemiology survey of lung transplantation recipients accepting surgeries during COVID-19 pandemic：from area near Hubei Province (Preprint)

2020 ◽  
Author(s):  
Lingxiao Qiu ◽  
Shanshan Chen ◽  
Cong Wang ◽  
Caihong Liu ◽  
Huaqi Wang ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Clinical Characteristics ◽  
Lung Transplant ◽  
The Novel ◽  
Web Based ◽  
Transplant Program ◽  
Medical Institutions ◽  
Survey Results ◽  
Wbc Count ◽  
Novel Coronavirus

BACKGROUND Lung transplantation recipients (LTx) are more susceptible to severe acute respiratory syndrome-corona virus-2 (SARS-Cov-2) and suffer severer outcomes than healthy subjects. OBJECTIVE Here we aim to analyze whether it was appropriate to maintain lung transplant programs in medical institutions accepting coronavirus disease 2019 (COVID-19) patients. METHODS Methods: the clinical characteristics, laboratory testing, and epidemiology survey results of 10 LTx recipients undergoing allograft lung transplantation surgeries in the First Affiliated Hospital of Zhengzhou University during the COVID-19 pandemic were collected. A web-based epidemiology questionnaire was used to collect the information of LTx recipients after discharge. RESULTS A total of 10 LTx recipients were identified. The main cause of lung transplantation was idiopathic interstitial pneumonia (60%), with another rare case of cystic fibrosis. Comorbidities involved hyperlipidemia, subclinical hyperthyroidism, diabetes, viral hepatitis of type B. The average white blood cell (WBC) count and average lymphocyte count were 9.5±3.9×109 cells/liter and 1.7±1.1×109 cells/liter, respectively. 40% of the LTx recipients had lymphopenia. Impaired alanine aminotransferase (ALT) and aspartate transaminase (AST) were observed in LTx recipients. Good habitats of hand hygiene (100%), wearing protective masks behaviors (100%), indoor ventilation behaviors (100%), indoor disinfection measures (83%), personal tableware (67%), separate room (100%), personal bedsheets/ quilts (100%) and drinking glasses (100%) were observed during the follow-up. None of the LTx recipients or their family members get infected with SARS-CoV-2 during the novel coronavirus pandemic. CONCLUSIONS Under the premise of taking appropriate preventive measures during hospitalization and after discharge, the lung transplant program can be maintained in the medical institution that accepts patients with COVID-19. INTERNATIONAL REGISTERED REPORT RR2-doi: https://doi.org/10.1101/2020.07.06.20147264

scholarly journals Implantable System for Treprostinil and Lung Transplantation: Case Series from Delivery for Pulmonary Arterial Hypertension Study

2021 ◽  
pp. 204589402199929
Author(s):  
Jeremy Feldman ◽  
Mardi Gomberg-Maitland ◽  
Shelly M Shapiro ◽  
Amy Lautenbach ◽  
Marty Morris ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Lung Transplantation ◽  
Lung Transplant ◽  
Case Series ◽  
Patient Characteristics ◽  
Effective Strategies ◽  
Transplant Program ◽  
Pulmonary Arterial ◽  
Bilateral Lung

Background The implanted system for treprostinil (IST) has been described in previous publications. There is no information published about how to handle this system around lung or heart lung transplantation. We present the experience from the DelIVery for Pulmonary Arterial Hypertension (PAH) study. Methods Of the 60 subjects enrolled in the DelIVery study, seven subjects from five pulmonary arterial hypertension (PAH) centers had been listed for bilateral lung or heart and lung transplant, and were included in this analysis. All subjects were participating in the previously described DelIVery for PAH study. 1,2 Results Seven subjects with implanted pumps have been listed for lung or heart-lung transplant. Six subjects underwent lung or heart lung transplantation and one remains on the transplant list. Three different methods of patient management for transplant were used. In three subjects the implanted system was filled with saline prior to transplantation and treprostinil was infused via an external system. Three subjects had their drug-filled implanted pump and catheter system explanted at the time of transplant. One patient had the drug-filled implanted system removed prior to being listed for transplantation. Four subjects were hospitalized while waiting for transplantation. Conclusion The eight year experience from the DelIVery for PAH study confirms that the IST is not a barrier to safe lung or heart lung transplantation. The experience described here provides three effective strategies for managing the implanted system around lung or heart lung transplantation. The optimal strategy will depend on patient characteristics and lung transplant program preferences and wait list times.

scholarly journals Lung transplantation: how we do it

2021 ◽  
Author(s):  
John Santosh Murala ◽  
Hashim Muhammad Hanif ◽  
Matthias Peltz ◽  
Sreekanth Reddy Cheruku ◽  
Lynn Custer Huffman ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Pulmonary Disease ◽  
Median Survival ◽  
Gold Standard ◽  
Lung Transplant ◽  
Transplant Program ◽  
The World ◽  
End Stage

AbstractLung transplantation is considered the gold standard for patients with chronic end-stage pulmonary disease. However, due to the complexity of management and relatively lower median survival as compared to other solid organs, many programs across the world have been slow to adopt the same. In our institution, we started lung transplantation in September 1990. And since then, we performed close to 900 lung transplantations. Here, we describe in detail the operative steps adopted in our institution for a successful lung transplantation. There have been very few variations over the years. We believe that having a standardized technique is one of the important features for success of a lung transplant program.

scholarly journals Clinical characteristics and epidemiology survey of lung transplantation recipients accepting surgeries during the COVID-19 pandemic : from area near Hubei Province

2020 ◽  
Author(s):  
Lingxiao Qiu ◽  
Shan shan Chen ◽  
Cong Wang ◽  
Caihong Liu ◽  
Huaqi Wang ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Clinical Characteristics ◽  
Lung Transplant ◽  
Preventive Measures ◽  
The Novel ◽  
Web Based ◽  
Transplant Program ◽  
Medical Institutions ◽  
Survey Results ◽  
Novel Coronavirus

AbstractLung transplantation recipients (LTx) were susceptible to severe acute respiratory syndrome-corona virus-2 (SARS-Cov-2) and suffered a higher mortality risk than healthy subjects. Here we aim to analyze whether it was appropriate or and valuable to maintain lung transplant programs in medical institutions accepting coronavirus disease 2019 (COVID-19) patients. In this study, the clinical characteristics, laboratory testing and epidemiology survey results of 10 LTx recipients undergoing allograft lung transplantation surgeries in the First Affiliated Hospital of Zhengzhou University during the COVID-19 pandemic were collected. A web-based epidemiology questionnaire was used to collect the information of LTx recipients after discharge. Up to now, none of the LTx recipients or their family members get infected with SARS-CoV-2 during the novel coronavirus pandemic. In conclusion, under the premise of taking appropriate preventive measures during hospitalization and after discharge, the lung transplant program can be maintained in the medical institution that accepts patients with COVID-19.

Deciding about Lung Transplantation: Informational Needs of Patients and Support Persons

2007 ◽  
Vol 17 (3) ◽  
pp. 183-192 ◽  
Author(s):  
Sharon Moloney ◽  
Lisa Cicutto ◽  
Michael Hutcheon ◽  
Lianne Singer
Keyword(s):  
Decision Making ◽  
Lung Transplantation ◽  
Lung Transplant ◽  
Qualitative Content Analysis ◽  
Informed Decision ◽  
Supplementary Information ◽  
Learning Needs ◽  
Informational Needs ◽  
Support Person ◽  
Transplant Program

Context Information is essential for informed decision making. To date, the informational needs of patients and support persons making the lung transplant decision are unexplored; in addition, the role of support persons in the transplant decision is unknown. Objective To identify the informational needs of patients and support persons attending a transplant clinic for consultation on lung transplantation, and to identify the involvement of support persons in the decision. Design A qualitative descriptive study and qualitative content analysis. Setting—Participants were recruited from the Toronto General Hospital Lung Transplant Program. Participants Twenty-two patients (8 candidates, 14 recipients) and 16 support persons. Results Most patients made the lung transplant decision in collaboration with their support person and reported receiving adequate information to make an informed decision. Diverse learning needs were identified among and between patients and support persons. Many participants identified the need for more information on practical issues, life after transplantation, and the experiences of transplant recipients. Conclusion Most patients attending a transplant clinic for consultation on lung transplantation felt they made an informed decision; however, modifications to the content, timing, and ways of providing information could enhance the decision-making process for patients and support persons. Specifically, the transplant team can provide information on core lung transplant topics with access to supplementary information to meet specific needs and use materials that vary in source, formats, and time points during the decision-making period.

Evolution of Donor Lung Utilization after Initiation of New Lung Transplant Program

2014 ◽  
Vol 33 (4) ◽  
pp. S262-S263
Author(s):  
T. Laisaar ◽  
M. Savisaar ◽  
A. Küüsvek ◽  
J. Milk ◽  
A. Rehme ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Transplant Program ◽  
Donor Lung

Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection

2004 ◽  
Vol 286 (6) ◽  
pp. L1129-L1139 ◽  
Author(s):  
Tina L. Sumpter ◽  
David S. Wilkes
Keyword(s):  
Lung Transplantation ◽  
Lung Transplant ◽  
Transplant Rejection ◽  
Survival Rates ◽  
Definitive Treatment ◽  
Solid Organ ◽  
Type V Collagen ◽  
End Stage ◽  
Type V

Lung transplantation is the only definitive treatment modality for many forms of end-stage lung disease. However, the lung is rejected more often than any other type of solid organ allograft due to chronic rejection known as bronchiolitis obliterans (BO). Indeed, BO is the primary reason why the 5- and 7-yr survival rates are worse for the lung than for any other transplanted organ. Alloimmunity to donor antigens is established as the primary mechanism that mediates rejection responses. However, newer immunosuppressive regimens designed to abrogate alloimmune activation have not improved survival. Therefore, these data suggest that other antigens, unrelated to donor transplantation antigens, are involved in rejection. Utilizing human and rodent studies of lung transplantation, our laboratory has documented that a native collagen, type V collagen [col(V)], is a target of the rejection response. Col(V) is highly conserved; therefore, these data indicate that transplant rejection involves both alloimmune and autoimmune responses. The role of col(V) in lung transplant rejection is described in this review article. In addition, the potential role of regulatory T cells that are crucial to modulating autoimmunity and alloimmunity is also discussed.

Outcomes After Lung Transplantation and Practices of Lung Transplant Programs in the United States Regarding Hepatitis C Seropositive Recipients

2011 ◽  
Vol 91 (11) ◽  
pp. 1293-1296 ◽  
Author(s):  
Tse-Ling Fong ◽  
Yong W. Cho ◽  
Linda Hou ◽  
Ian V. Hutchinson ◽  
Richard G. Barbers ◽  
...  
Keyword(s):  
United States ◽  
Hepatitis C ◽  
Lung Transplantation ◽  
Lung Transplant ◽  
The United States

scholarly journals Detrimental Association of Hypogammaglobulinemia With Chronic Lung Allograft Dysfunction and Death Is Not Mitigated by On-Demand Immunoglobulin G Replacement After Lung Transplantation

2018 ◽  
Vol 29 (1) ◽  
pp. 18-25
Author(s):  
Alicia B. Lichvar ◽  
Christopher R. Ensor ◽  
Adriana Zeevi ◽  
Matthew R. Morrell ◽  
Joseph M. Pilewski ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Immunoglobulin G ◽  
Lung Transplant ◽  
Primary Outcome ◽  
Transplant Recipients ◽  
Chronic Lung Allograft Dysfunction ◽  
On Demand ◽  
Allograft Dysfunction ◽  
Group 2 ◽  
Lung Transplant Recipients

Background: Hypogammaglobulinemia (HGG), immunoglobulin G (IgG) <700 mg/dL, is associated with infections, chronic lung allograft dysfunction, and death following lung transplantation. This study evaluates the use of on-demand intravenous IgG in lung transplant recipients with HGG. Materials and Methods: This single-center retrospective cohort study of adult lung recipients evaluated 3 groups, no, untreated (u), or treated (t) HGG at first IgG administration or a matched time posttransplant. Primary outcome was freedom from allograft dysfunction. Secondary outcomes included development of advanced dysfunction, rejection, infection burden, and mortality. Results: Recipients included 484 (no HGG: 76, uHGG: 192, tHGG: 216). Freedom from chronic allograph dysfunction was highest in the non-HGG group 2 years post-enrollment (no HGG 77.9% vs uHGG 56.4% vs tHGG 52.5%; P = .002). Freedom from advanced dysfunction was significantly different 2 years post-enrollment (no HGG 90.5% vs uHGG 84.7% vs tHGG 75.4%; P = .017). Patients without HGG and those with uHGG had less mortality at 2 years post-enrollment (no HGG 84.2% vs uHGG 81.3% vs tHGG 64.8%; P < .001). Gram-negative pneumonias occurred more often in the tHGG group ( P = .02). Conclusions: Development of chronic lung allograft dysfunction, patient survival, rejection burden, and key infectious outcomes in lung transplant recipients were still problematic in the context of on-demand IgG therapy. Prospective studies are warranted.

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