scholarly journals Endocarditis due to Bartonella quintana, the etiological agent of trench fever

2020 ◽  
Vol 192 (49) ◽  
pp. E1723-E1726
Author(s):  
Carl Boodman ◽  
Terence Wuerz ◽  
Philippe Lagacé-Wiens
Keyword(s):  
Etiological Agent ◽  
Bartonella Quintana ◽  
Trench Fever

scholarly journals Culture and Antibiotic Susceptibility of Bartonella quintana in Human Erythrocytes

2003 ◽  
Vol 47 (2) ◽  
pp. 614-619 ◽  
Author(s):  
Jean-Marc Rolain ◽  
Max Maurin ◽  
Marie-Noëlle Mallet ◽  
Daniel Parzy ◽  
Didier Raoult
Keyword(s):  
Culture System ◽  
Homeless People ◽  
Peak Level ◽  
Human Erythrocytes ◽  
Beta Lactams ◽  
Laser Confocal Microscopy ◽  
Bartonella Quintana ◽  
Trench Fever ◽  
Species Specific

ABSTRACT Bartonella quintana, the agent of trench fever, has recently been implicated in various diseases, in particular, bacteremia and endocarditis in homeless people. The host cell of Bartonella spp. is believed to be the erythrocyte, and in the present study we demonstrate that B. quintana can be cultured in vitro in human erythrocytes. The bacteria were found to be intraerythrocytic by laser confocal microscopy with Bartonella species-specific monoclonal antibodies. Infections with B. quintana decreased the life span of erythrocytes in culture from 8.6 to 4.8 days. In the culture system we found that most of the antibiotics that we tested (doxycycline, fluoroquinolone compounds, and beta-lactams) were not bactericidal. Gentamicin was bactericidal at 4 μg/ml, as was rifampin, but to a lesser extent. At this concentration, gentamicin has been shown to enter erythrocytes slowly and to reach a peak level of 0.26 μg/ml after 24 h. At 0.26 μg/ml, however, we found that gentamicin was not able to kill extracellular B. quintana, even after 96 h of incubation. We hypothesize that erythrocytes may be a reservoir for B. quintana and that the bactericidal activity of gentamicin that we observed occurs mainly when the bacteria emerge from the erythrocytes and are found extracellularly. It would appear that gentamicin should be administered for at least 5 days to cure patients infected with B. quintana.

scholarly journals Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever

2015 ◽  
Vol 9 (6) ◽  
pp. e0003871 ◽  
Author(s):  
Hamza Leulmi ◽  
Idir Bitam ◽  
Jean Michel Berenger ◽  
Hubert Lepidi ◽  
Jean Marc Rolain ◽  
...  
Keyword(s):  
Cimex Lectularius ◽  
Bed Bugs ◽  
Bartonella Quintana ◽  
Trench Fever

Bartonella (Rochalimaea) quintana infections.

1996 ◽  
Vol 9 (3) ◽  
pp. 273-292 ◽  
Author(s):  
M Maurin ◽  
D Raoult
Keyword(s):  
Endothelial Cells ◽  
Antibiotic Therapy ◽  
Homeless People ◽  
Chronic Alcoholism ◽  
The United States ◽  
Etiological Agent ◽  
Louse Infestation ◽  
Bacillary Angiomatosis ◽  
Trench Fever

Bartonella (formerly Rochalimaea) quintana is the etiological agent of trench fever, a disease extensively reported during the World Wars. Recent molecular biology approaches have allowed dramatic extension of the spectrum of Bartonella infections. B. quintana is now also recognized as an etiological agent of fever and bacteremia, endocarditis, bacillary angiomatosis, and chronic lymphadenopathy. Human immunodeficiency virus-infected patients and/or homeless people are the most vulnerable to infection. Poverty and louse infestation were the main epidemiological factors associated with B. quintana infections during wartime. Although poverty and chronic alcoholism have been associated with modern cases of trench fever and bacteremia due to B. quintana in Europe and the United States, vectors for B. quintana have not been clearly identified and B. quintana has not been isolated from modern-day lice. Microscopic bacillary angiomatosis lesions are characterized by tumor-like capillary lobules, with proliferating endothelial cells. In vitro experiments have shown that B. quintana survives within endothelial cells and stimulates cell proliferation. These observations, together with the finding that lesions may regress when antibiotic therapy is administered, strongly suggest that B. quintana itself stimulates angiogenesis. Bartonella infections are characterized by a high frequency of relapses after brief courses of antibiotic therapy. It is to be noted that in vitro, although Bartonella species are highly susceptible to antibiotics, only the aminoglycosides have proved to be bactericidal. However, the most effective antibiotic regimen for Bartonella infections remains to be established.

scholarly journals 1.Proliferation sites of Bartonella quintana, agent of trench fever in body lice(Proceedings of the 59th Annual Meeting of Eastern Region)

2008 ◽  
Vol 59 (2) ◽  
pp. 103
Author(s):  
M. Kobayashi ◽  
N. Seki ◽  
S. Kasai ◽  
K. Tanaka ◽  
O. Komagata ◽  
...  
Keyword(s):  
Annual Meeting ◽  
Eastern Region ◽  
Bartonella Quintana ◽  
Trench Fever ◽  
Body Lice

scholarly journals Bartonella quintana and Urban Trench Fever

2000 ◽  
Vol 31 (1) ◽  
pp. 131-135 ◽  
Author(s):  
M. E. Ohl ◽  
D. H. Spach
Keyword(s):  
Bartonella Quintana ◽  
Trench Fever

scholarly journals Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever

2015 ◽  
Vol 9 (5) ◽  
pp. e0003789 ◽  
Author(s):  
Hamza Leulmi ◽  
Idir Bitam ◽  
Jean Michel Berenger ◽  
Hubert Lepidi ◽  
Jean Marc Rolain ◽  
...  
Keyword(s):  
Cimex Lectularius ◽  
Bed Bugs ◽  
Bartonella Quintana ◽  
Trench Fever

Trench Fever: A Bartonella Quintana Infection

2020 ◽  
pp. 171-175
Author(s):  
Muhammad Imran Qadir ◽  
Basra Manzoor
Keyword(s):  
Bartonella Quintana ◽  
Trench Fever

scholarly journals Five millennia of Bartonella quintana bacteremia

2020 ◽  
Author(s):  
Ba-Hoang-Anh Mai ◽  
Rémi Barbieri ◽  
Thomas Chenal ◽  
Dominique Castex ◽  
Richard Jonvel ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Bartonella Quintana ◽  
Exact Test ◽  
Trench Fever ◽  
Positive Rate ◽  
Military Populations ◽  
The Difference ◽  
Negative Controls ◽  
The Relationship

ABSTRACTBartonella quintana caused trench fever in the framework of two World Wars and is now recognized as an agent of re-emerging infection. Many reports indicated the popularity of B. quintana exposure since the 90s. For evaluating its prevalence in ancient populations, we used real-time PCR to detect B. quintana DNA in 400 teeth collected from 145 individuals dating from the 1st to 19th centuries in nine archeological sites with the presence of negative controls. Fisher’s exact test was used to compare the prevalence of B. quintana detection in civil and military populations. B. quintana DNA was confirmed in a total of 28/145 (19.3%) individuals, comprising 78 citizens and 67 soldiers, 20.1% and 17.9% of which were positive for B. quintana bacteremia, respectively. This study collected previous studies on these ancient samples and showed that the presence of B. quintana infection followed the course of time in human history; a total of 14/15 sites from five European countries had a positive prevalence. The positive rate in soldiers was higher than those of citizens, with 20% and 18.8%, respectively, in the 18th - 19th centuries, but the difference in frequency was not significant. These results confirmed the role of dental pulp in diagnosing B. quintana bacteremia in ancient populations and showed the incidence of B. quintana in both citizens and soldiers. Many recent findings contributed to understanding the coevolution of the relationship between B. quintana and humans.

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