scholarly journals Investigation on the flow properties and compresibilities of different direct tableting agents by using pyridoxine hydrochloride as a model drug

2009 ◽  
Vol 38 (4) ◽  
pp. 331-344
Author(s):  
KILIÇARSLAN Müge; ÇAMCA
Keyword(s):  
Pyridoxine Hydrochloride ◽  
Flow Properties ◽  
Model Drug ◽  
Direct Tableting

scholarly journals Contrasting the crospovidones functionality as excipients for direct compression

2015 ◽  
Vol 51 (1) ◽  
pp. 155-171 ◽  
Author(s):  
Daniel García Ramírez ◽  
Leopoldo Villafuerte Robles
Keyword(s):  
Drug Product ◽  
Absolute Number ◽  
Powder Flow ◽  
Direct Compression ◽  
Flow Properties ◽  
Technological Performance ◽  
A Value ◽  
Tablet Disintegration ◽  
Input Variables ◽  
Model Drug

Specific values of technological properties of excipients allow the establishment of numerical parameters to define and compare their functionality. This study investigates the functionality of Polyplasdones XL and XL10. Parameters studied included tablet disintegration profiles, compactibility profiles and powder flow. The results allowed the establishment of quantitative surrogate functionalities of technological performance, such as absolute number, and as a value relative to the known microcrystalline cellulose type 102. Moreover, the establishment of an explicit functionality to improve the technological performance of two diluents and a model drug was investigated, as was setting up of these functionalities, as quantitative values, to determine the input variables of each material and its probable functionality in a drug product. Disintegration times of pure Polyplasdone XL and its admixtures were around half that of Polyplasdone XL10. The improvement in tablet compactibility was 25-50% greater for Polyplasdone XL10 than Polyplasdone XL. Crospovidones proportions of up to 10% have little effect on the flow properties of other powders, although pure Polyplasdone XL10 and its admixtures display compressibility indexes about 20% greater than Polyplasdone XL. The observed results are in line with a smaller particle size of Polyplasdone XL10 compared to Polyplasdone XL.

scholarly journals Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient

2021 ◽  
Author(s):  
Kumbakonam Balachandran Ilango ◽  
Senguttuvan Gowthaman ◽  
Kumbakonam Ilango Seramaan ◽  
Kumarappan Chidambaram ◽  
Mohammad F Bayan ◽  
...  
Keyword(s):  
In Vitro Cytotoxicity ◽  
In Vitro Dissolution ◽  
Wet Granulation ◽  
Flow Properties ◽  
Disintegration Time ◽  
Coccinia Grandis ◽  
Mtt Method ◽  
Model Drug ◽  
Instrumental Methods

Mucilage from Coccinia grandis was extracted, isolated by maceration technique and precipitated, accordingly. The mucilage was evaluated for its physicochemical, binding, and disintegrant properties in tablets using paracetamol as a model drug. The crucial physicochemical properties such as flow properties, solubility, swelling index, loss on drying, viscosity, pH, microbial load, cytotoxicity were evaluated and the compatibility was analysed using sophisticated instrumental methods (TGA, DTA, DSC, and FTIR). The binding properties of the mucilage were used at three different concentrations and compared with starch and PVP as standard binders. The disintegrant properties of mucilage were used at two different concentrations and compared with standard disintegrants MCCP, SSG, and CCS. The wet granulation technique was used for the preparation of granules and was evaluated for the flow properties. The tablets were punched and evaluated for their hardness, friability, assay, disintegration time, in vitro dissolution profiles. In vitro cytotoxicity study of the mucilage was performed in human embryonic kidney (HEK) cell line using cytotoxic assay by MTT method. The outcome of the study indicated that the mucilage had good performance when compared with starch and PVP. Further, the mucilage acts as a good disintegrant than MCCP, SSG and CCS to paracetamol tablets. Moreover, the in vitro cytotoxicity evaluation results demonstrated that the mucilage is non-cytotoxic to human cells and is safe.

Physical and Hydrologic-Flow Properties of Fractures Las Vegas, Nevada—Zion Canyon, Utah—Grand Canyon, Arizona—Yucca Mountain, Nevada July 20–24, 1989

10.1029/ft385 ◽  
1989 ◽  
Author(s):  
Christopher C. Barton ◽  
Paul A. Hsieh ◽  
Jacques Angelier ◽  
Francoise Bergerat ◽  
Catherine Bouroz ◽  
...  
Keyword(s):  
Las Vegas ◽  
Grand Canyon ◽  
Yucca Mountain ◽  
Flow Properties

Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Mashkura Ashrafi ◽  
Jakir Ahmed Chowdhury ◽  
Md Selim Reza
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
In Vitro Release ◽  
Correlation Coefficients ◽  
High Ratio ◽  
Water Soluble ◽  
Metformin Hydrochloride ◽  
Model Drug ◽  
Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size ‘1’. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Blood Cell Separation Device Using Serially Connected Membrane Filters for Adapting to Blood Flow Properties

2009 ◽  
Vol 129 (11) ◽  
pp. 380-386 ◽  
Author(s):  
Taizo Kobayashi ◽  
Daiki Kato ◽  
Hiroyuki Koga ◽  
Kenichi Morimoto ◽  
Makoto Fukuda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Cell Separation ◽  
Flow Properties ◽  
Separation Device ◽  
Membrane Filters

Capillary flow properties of porous wicks

1988 ◽  
Author(s):  
J. AMBROSE ◽  
L. CHOW ◽  
J. BEAM
Keyword(s):  
Capillary Flow ◽  
Flow Properties

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

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