scholarly journals Effects of polymer type, polymer: direct tabletting agent ratio and tabletting method on verapamil hydrochloride extended release from hydroxypropylmethylcellulose matrix tablets: polimer tipinin, pol

2004 ◽  
pp. 001-013
Author(s):  
Evren ALĞIN
Keyword(s):  
Extended Release ◽  
Matrix Tablets ◽  
Verapamil Hydrochloride ◽  
Direct Tabletting ◽  
Polymer Type

Optimization of extended-release hydrophilic matrix tablets by support vector regression

2010 ◽  
Vol 37 (1) ◽  
pp. 80-87
Author(s):  
Nizar Al-Zoubi ◽  
Kyriakos Kachrimanis ◽  
Khaled Younis ◽  
Stavros Malamataris
Keyword(s):  
Support Vector Regression ◽  
Extended Release ◽  
Matrix Tablets ◽  
Support Vector ◽  
Hydrophilic Matrix

Evaluation of stereoselective dissolution of verapamil hydrochloride from matrix tablets press-coated with chiral excipients

1996 ◽  
Vol 136 (1-2) ◽  
pp. 43-51 ◽  
Author(s):  
L. Maggi ◽  
G. Massolini ◽  
E. De Lorenzi ◽  
U. Conte ◽  
G. Caccialanza
Keyword(s):  
Matrix Tablets ◽  
Verapamil Hydrochloride

scholarly journals Preparation and scale up of extended-release tablets of bromopride

2014 ◽  
Vol 50 (2) ◽  
pp. 291-300 ◽  
Author(s):  
Guilherme Neves Ferreira ◽  
Marcos Giovani Rodrigues Silva ◽  
Aline Guerra Manssour Fraga ◽  
Luiz Cláudio Rodrigues Pereira da Silva ◽  
Luiz Marcelo Lira ◽  
...  
Keyword(s):  
Sustained Release ◽  
Mathematical Models ◽  
Extended Release ◽  
Scale Up ◽  
Study Data ◽  
Matrix Tablets ◽  
Tableting Machine ◽  
Compaction Behavior ◽  
Mathematical Equations ◽  
And Control

Reproducibility of the tablet manufacturing process and control of its pharmaceutics properties depends on the optimization of formulation aspects and process parameters. Computer simulation such as Design of Experiments (DOE) can be used to scale up the production of this formulation, in particular for obtaining sustained-release tablets. Bromopride formulations are marketed in the form of extended-release pellets, which makes the product more expensive and difficult to manufacture. The aim of this study was to formulate new bromopride sustained release formulations as tablets, and to develop mathematical models to standardize the scale up of this formulation, controlling weight and hardness of the tablets during manufacture according to the USP 34th edition. DOE studies were conducted using Minitab(tm) software. Different excipient combinations were evaluated in order to produce bromopride sustained-release matrix tablets. In the scale-up study, data were collected and variations in tableting machine parameters were measured. Data were processed by Minitab(tm) software, generating mathematical equations used for prediction of powder compaction behavior, according to the settings of the tableting machine suitable for scale-up purposes. Bromopride matrix tablets with appropriate characteristics for sustained release were developed. The scale-up of the formulation with the most suitable sustained release profile was established by using mathematical models, indicating that the formulation can be a substitute for the pellets currently marketed.

scholarly journals Development and evaluation of natural gum-based extended release matrix tablets of two model drugs of different water solubilities by direct compression

2016 ◽  
Vol 24 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Kwabena Ofori-Kwakye ◽  
Kwadwo Amanor Mfoafo ◽  
Samuel Lugrie Kipo ◽  
Noble Kuntworbe ◽  
Mariam El Boakye-Gyasi
Keyword(s):  
Extended Release ◽  
Matrix Tablets ◽  
Direct Compression ◽  
Natural Gum
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