scholarly journals Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis

2021 ◽  
Vol 9 (22) ◽  
Author(s):  
Zahra K. Farahani ◽  
Mahnaz Taherianfard ◽  
Mohamad Mehdi Naderi ◽  
Hortensia Ferrero
Keyword(s):  
Therapeutic Effect ◽  
Rat Model ◽  
Neurotrophic Factors ◽  
Pain Sensitivity ◽  
Royal Jelly ◽  
Lesion Size ◽  
Endometriotic Lesion

Therapeutic Effect of Ribbon-Type Nuclear Factor-κB Decoy Oligonucleotides in a Rat Model of Inflammatory Bowel Disease

2012 ◽  
Vol 12 (6) ◽  
pp. 484-492 ◽  
Author(s):  
Kazunari Ozaki ◽  
Hirofumi Makino ◽  
Motokuni Aoki ◽  
Takashi Miyake ◽  
Natsuki Yasumasa ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Bowel Disease ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Inflammatory Bowel

Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study

2015 ◽  
Vol 31 (5) ◽  
pp. 388-391 ◽  
Author(s):  
Oytun Erbas ◽  
Halil Gursoy Pala ◽  
Emel Ebru Pala ◽  
Burcu Artunc Ulkumen ◽  
Levent Akman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Model Study ◽  
Experimental Rat Model

scholarly journals Do Early MRI Signals Predict Lesion Size in a Neonatal Stroke Rat Model?

2012 ◽  
Vol 34 (7) ◽  
pp. E73-E76 ◽  
Author(s):  
S. Fau ◽  
C. Po ◽  
C. Goyenvalle ◽  
P. Meric ◽  
C. Charriaut-Marlangue
Keyword(s):  
Rat Model ◽  
Lesion Size ◽  
Neonatal Stroke

scholarly journals The Therapeutic Effect of Human Adult Stem Cells Derived from Adipose Tissue in Endotoxemic Rat Model

2013 ◽  
Vol 10 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Soyoung Shin ◽  
Yonggoo Kim ◽  
Sikyoung Jeong ◽  
Sungyoup Hong ◽  
Insoo Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Adult Stem Cells ◽  
Human Adult

scholarly journals Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model

2018 ◽  
Vol Volume 11 ◽  
pp. 2663-2674 ◽  
Author(s):  
Baowen Liu ◽  
Yi Liu ◽  
Ningbo Li ◽  
Jin Zhang ◽  
Xianwei Zhang
Keyword(s):  
Rat Model ◽  
Neurotrophic Factors ◽  
Post Surgery

scholarly journals Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Zhixing Jin ◽  
Li Wang ◽  
Zhiling Zhu
Keyword(s):  
Cell Proliferation ◽  
Rat Model ◽  
Flow Cytometric Analysis ◽  
Lesion Size ◽  
Negative Control ◽  
Terminal Deoxynucleotidyl Transferase ◽  
High Dose ◽  
Sprague Dawley ◽  
Induced Apoptosis ◽  
Cd4 Lymphocytes

Objective. To evaluate the effect of GuiXiong Xiaoyi Wan (GXXYW) on the development of endometriosis in a rat model.Methods. Sprague-Dawley rats with surgically induced endometriosis were randomly treated with low-dose GXXYW, high-dose GXXYW, or vehicle (negative control) for 28 days. Immunohistochemistry was used to assess cell proliferation in the lesions. The terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP biotin nick end labelling (TUNEL) method was performed to analyse the apoptosis induced by GuiXiong Xiaoyi Wan. The percentages of CD3+ lymphocytes, CD4+ lymphocytes, and CD8+ lymphocytes in the spleens of the rats were evaluated using flow cytometric analysis.Results. Treatment with GXXYW significantly decreased the lesion size, inhibited cell proliferation, and induced apoptosis in endometriotic tissue. The spleens of GXXYW-treated rats also demonstrated a significant increase in the percentage of CD4+ lymphocytes and a significant decrease in the percentage of CD8+ lymphocytes.Conclusions. These results suggest that, in a rat model, GXXYW may be effective in the suppression of the growth of endometriosis, possibly through the inhibition of cell proliferation, the induction of apoptosis of endometriotic cells, and the regulation of the immune system.

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