scholarly journals Transcriptional profiles of genes related to electrophysiological function in Scn5a +/− murine hearts

2021 ◽  
Vol 9 (19) ◽  
Author(s):  
Michael Takla ◽  
Charlotte E. Edling ◽  
Kevin Zhang ◽  
Khalil Saadeh ◽  
Gary Tse ◽  
...  
Keyword(s):  
Transcriptional Profiles

scholarly journals Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyed-Mohammad Mazloomi ◽  
Mitra Foroutan-Ghaznavi ◽  
Vahid Montazeri ◽  
Gholamreza Tavoosidana ◽  
Ashraf Fakhrjou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Target Genes ◽  
Case Series ◽  
Clinicopathological Features ◽  
Cell Junctions ◽  
Homologous Gene ◽  
Axillary Lymph ◽  
Luminal A ◽  
Transcriptional Profiles ◽  
First Time

Abstract Background Metastasis accounts for ninety percent of breast cancer (BrCa) mortality. Cortactin, Ras homologous gene family member A (RhoA), and Rho-associated kinase (ROCK) raise cellular motility in favor of metastasis. Claudins (CLDN) belong to tight junction integrity and are dysregulated in BrCa. Thus far, epidemiologic evidence regarding the association of different pro-metastatic genes with pathological phenotypes of BrCa is largely inconsistent. This study aimed to determine the possible transcriptional models of pro-metastatic genes incorporate in holding the integrity of epithelial cell–cell junctions (CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4), for the first time, in association with clinicopathological features of primary BrCa. Methods In a consecutive case-series design, 206 newly diagnosed non-metastatic eligible BrCa patients with histopathological confirmation (30–65 years) were recruited in Tabriz, Iran (2015–2017). Real-time RT-PCR was used. Then fold changes in the expression of target genes were measured. Results ROCK amplification was associated with the involvement of axillary lymph node metastasis (ALNM; ORadj. = 3.05, 95%CI 1.01–9.18). Consistently, inter-correlations of CTTN-ROCK (β = 0.226, P < 0.05) and RhoA-ROCK (β = 0.311, P < 0.01) were determined among patients diagnosed with ALNM+ BrCa. In addition, the overexpression of CLDN-4 was frequently observed in tumors identified by ALNM+ or grade III (P < 0.05). The overexpression of CTTN, CLDN-1, and CLDN-4 genes was correlated positively with the extent of tumor size. CTTN overexpression was associated with the increased chance of luminal-A positivity vs. non-luminal-A (ORadj. = 1.96, 95%CI 1.02–3.77). ROCK was also expressed in luminal-B BrCa tumors (P < 0.05). The estrogen receptor-dependent transcriptions were extended to the inter-correlations of RhoA-ROCK (β = 0.280, P < 0.01), ROCK-CLDN-2 (β = 0.267, P < 0.05), and CLDN-1-CLDN-4 (β = 0.451, P < 0.001). Conclusions For the first time, our findings suggested that the inter-correlations of CTTN-ROCK and RhoA-ROCK were significant transcriptional profiles determined in association with ALNM involvement; therefore the overexpression of ROCK may serve as a potential molecular marker for lymphatic metastasis. The provided binary transcriptional profiles need more approvals in different clinical features of BrCa metastasis.

PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS

Shock ◽  
2016 ◽  
Vol 45 (4) ◽  
pp. 411-418 ◽  
Author(s):  
Steven M. Opal ◽  
James L. Ellis ◽  
Vipin Suri ◽  
Johannes M. Freudenberg ◽  
George P. Vlasuk ◽  
...  
Keyword(s):  
Experimental Sepsis ◽  
Transcriptional Profiles

Indistinguishable transcriptional profiles between in vitro- and in vivo-produced bovine fetuses

2011 ◽  
Vol 78 (9) ◽  
pp. 642-650 ◽  
Author(s):  
Le Jiang ◽  
Sadie L. Marjani ◽  
Marcelo Bertolini ◽  
Gary B. Anderson ◽  
Xiangzhong Yang ◽  
...  
Keyword(s):  
Transcriptional Profiles ◽  
Bovine Fetuses

scholarly journals Transcriptional profiles of the annual growth cycle in Populus deltoides

2008 ◽  
Vol 28 (3) ◽  
pp. 321-329 ◽  
Author(s):  
Sunchung Park ◽  
Daniel E. Keathley ◽  
Kyung-Hwan Han
Keyword(s):  
Populus Deltoides ◽  
Growth Cycle ◽  
Annual Growth ◽  
Transcriptional Profiles

scholarly journals An integrated analysis of mRNA and sRNA transcriptional profiles in tomato root: Insights on tomato wilt disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206765 ◽  
Author(s):  
Min Zhao ◽  
Hui-Min Ji ◽  
Ying Gao ◽  
Xin-Xin Cao ◽  
Hui-Ying Mao ◽  
...  
Keyword(s):  
Wilt Disease ◽  
Integrated Analysis ◽  
Tomato Root ◽  
Transcriptional Profiles ◽  
Tomato Wilt

scholarly journals Transcriptome Analyses Reveal Differential Transcriptional Profiles in Early- and Late-Dividing Porcine Somatic Cell Nuclear Transfer Embryos

Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1499
Author(s):  
Zhiguo Liu ◽  
Guangming Xiang ◽  
Kui Xu ◽  
Jingjing Che ◽  
Changjiang Xu ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Rna Processing ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Molecular Mechanisms ◽  
Differentially Expressed Gene ◽  
Blastocyst Stage ◽  
Developmental Competence ◽  
Rna Seq ◽  
Transcriptional Profiles

Somatic cell nuclear transfer (SCNT) is not only a valuable tool for understanding nuclear reprogramming, but it also facilitates the generation of genetically modified animals. However, the development of SCNT embryos has remained an uncontrollable process. It was reported that the SCNT embryos that complete the first cell division sooner are more likely to develop to the blastocyst stage, suggesting their better developmental competence. Therefore, to better understand the underlying molecular mechanisms, RNA-seq of pig SCNT embryos that were early-dividing (24 h postactivation) and late-dividing (36 h postactivation) was performed. Our analysis revealed that early- and late-dividing embryos have distinct RNA profiles, and, in all, 3077 genes were differentially expressed. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that early-dividing embryos exhibited higher expression in genes that participated in the meiotic cell cycle, while enrichment of RNA processing- and translation-related genes was found in late-dividing embryos. There are also fewer somatic memory genes such as FLRT2, ADAMTS1, and FOXR1, which are abnormally activated or suppressed in early-dividing cloned embryos. These results show that early-dividing SCNT embryos have different transcriptional profiles than late-dividing embryos. Early division of SCNT embryos may be associated with their better reprogramming capacity, and somatic memory genes may act as a reprogramming barrier in pig SCNT reprogramming.

Genotype‐dependent regulation of vitamin E biosynthesis in olive fruits as revealed through metabolic and transcriptional profiles

Plant Biology ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 604-614 ◽  
Author(s):  
E. C. Georgiadou ◽  
G. Koubouris ◽  
V. Goulas ◽  
C. Sergentani ◽  
N. Nikoloudakis ◽  
...  
Keyword(s):  
Vitamin E ◽  
Transcriptional Profiles
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