scholarly journals Impact of coronary artery disease on contractile function and ventricular‐arterial coupling during exercise: Simultaneous assessment of left‐ventricular pressure–volume and coronary pressure and flow during cardiac catheterization

2021 ◽  
Vol 9 (10) ◽  
Author(s):  
Tiffany Patterson ◽  
Simone Rivolo ◽  
Daniel Burkhoff ◽  
Jan Schreuder ◽  
Natalia Briceno ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Catheterization ◽  
Contractile Function ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Coronary Pressure ◽  
Artery Disease ◽  
Simultaneous Assessment

scholarly journals Analysis of left ventricular pressure during isovolumic relaxation in coronary artery disease.

Circulation ◽  
1982 ◽  
Vol 65 (4) ◽  
pp. 690-697 ◽  
Author(s):  
D S Thompson ◽  
C B Waldron ◽  
S M Juul ◽  
N Naqvi ◽  
R H Swanton ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Ventricular Pressure ◽  
Artery Disease ◽  
Isovolumic Relaxation

Effects of Respiratory Alkalosis and Acidosis on Myocardial Blood Flow and Metabolism in Patients with Coronary Artery Disease 

1998 ◽  
Vol 89 (4) ◽  
pp. 831-837 ◽  
Author(s):  
Stephan Kazmaier ◽  
Andreas Weyland ◽  
Wolfgang Buhre ◽  
Heidrun Stephan ◽  
Horst Rieke ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Left Ventricular Pressure ◽  
Respiratory Alkalosis ◽  
Left Ventricular ◽  
Systemic Hemodynamics ◽  
Ventricular Pressure ◽  
Maximal Increase ◽  
Artery Disease

Background Variation of the arterial carbon dioxide partial pressure (PaCO2) is not uncommon in anesthetic practice. However, little is known about the myocardial consequences of respiratory alkalosis and acidosis, particularly in patients with coronary artery disease. The aim of the current study was to investigate the effects of variation in PaCO2 on myocardial blood flow (MBF), metabolism, and systemic hemodynamics in patients before elective coronary artery bypass graft surgery. Methods In 10 male anesthetized patients, measurements of MBF, myocardial contractility, metabolism, and systemic hemodynamics were made in a randomized sequence at PaCO2 levels of 30, 40, and 50 mmHg, respectively. The MBF was measured using the Kety-Schmidt technique with argon as a tracer. End-diastolic left ventricular pressure and the maximal increase of left ventricular pressure were assessed using a manometer-tipped catheter. Results The cardiac index significantly changed with varying PaCO2 levels (hypocapnia, - 9%; hypercapnia, 13%). This reaction was associated with inverse changes in systemic vascular resistance index levels. The MBF significantly increased by 15% during hypercapnia, whereas no change was found during hypocapnia. Myocardial oxygen and glucose uptake and the maximal increase of left ventricular pressure were not affected by varying PaCO2 levels. Conclusions In anesthetized patients with coronary artery disease, short-term variations in PaCO2 have significant effects on MBF but do not influence global myocardial oxygen and glucose uptake. Changes in systemic hemodynamics associated with respiratory alkalosis and acidosis are caused by changes in systemic vascular resistance rather than by alterations in myocardial contractility.

scholarly journals Impact of Arrhythmia on Myocardial Perfusion: A Computational Model-Based Study

Mathematics ◽  
2021 ◽  
Vol 9 (17) ◽  
pp. 2128
Author(s):  
Xinyang Ge ◽  
Sergey Simakov ◽  
Youjun Liu ◽  
Fuyou Liang
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Perfusion ◽  
Myocardial Ischemia ◽  
Computational Model ◽  
Left Ventricular Pressure ◽  
Left Ventricular ◽  
Metabolic Demand ◽  
Severe Coronary Artery ◽  
Artery Disease

(1) Background: Arrhythmia, which is an umbrella term for various types of abnormal rhythms of heartbeat, has a high prevalence in both the general population and patients with coronary artery disease. So far, it remains unclear how different types of arrhythmia would affect myocardial perfusion and the risk/severity of myocardial ischemia. (2) Methods: A computational model of the coronary circulation coupled to the global cardiovascular system was employed to quantify the impacts of arrhythmia and its combination with coronary artery disease on myocardial perfusion. Furthermore, a myocardial supply–demand balance index (MSDBx) was proposed to quantitatively evaluate the severity of myocardial ischemia under various arrhythmic conditions. (3) Results: Tachycardia and severe irregularity of heart rates (HRs) depressed myocardial perfusion and increased the risk of subendocardial ischemia (evaluated by MSDBx), whereas lowering HR improved myocardial perfusion. The presence of a moderate to severe coronary artery stenosis considerably augmented the sensitivity of MSDBx to arrhythmia. Further data analyses revealed that arrhythmia induced myocardial ischemia mainly via reducing the amount of coronary artery blood flow in each individual cardiac cycle rather than increasing the metabolic demand of the myocardium (measured by the left ventricular pressure-volume area). (4) Conclusions: Both tachycardia and irregular heartbeat tend to increase the risk of myocardial ischemia, especially in the subendocardium, and the effects can be further enhanced by concomitant existence of coronary artery disease. In contrast, properly lowering HR using drugs like β-blockers may improve myocardial perfusion, thereby preventing or relieving myocardial ischemia in patients with coronary artery disease.

scholarly journals Quantifying “normalized” regional left ventricular contractile function in ischemic coronary artery disease

2015 ◽  
Vol 150 (1) ◽  
pp. 240-246 ◽  
Author(s):  
Matthew C. Henn ◽  
Brian P. Cupps ◽  
Julia Kar ◽  
Kevin Kulshrestha ◽  
Danielle Koerner ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Contractile Function ◽  
Left Ventricular ◽  
Ischemic Coronary Artery Disease ◽  
Artery Disease

scholarly journals Improvement of left ventricular contractile function by exercise training in patients with coronary artery disease.

Circulation ◽  
1986 ◽  
Vol 74 (2) ◽  
pp. 350-358 ◽  
Author(s):  
A A Ehsani ◽  
D R Biello ◽  
J Schultz ◽  
B E Sobel ◽  
J O Holloszy
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Exercise Training ◽  
Contractile Function ◽  
Left Ventricular ◽  
Artery Disease
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