scholarly journals TRAIL inhibits oxidative stress in human aortic endothelial cells exposed to pro‐inflammatory stimuli

2020 ◽  
Vol 8 (20) ◽  
Author(s):  
Hannah Forde ◽  
Emma Harper ◽  
Keith D. Rochfort ◽  
Robert G. Wallace ◽  
Colin Davenport ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Aortic Endothelial Cells ◽  
Inflammatory Stimuli ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial

scholarly journals Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Nicholas T Hogan ◽  
Michael B Whalen ◽  
Lindsey K Stolze ◽  
Nizar K Hadeli ◽  
Michael T Lam ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Regulatory Elements ◽  
Transcriptional Networks ◽  
Aortic Endothelial Cells ◽  
Genome Wide ◽  
A Genome ◽  
Gata Transcription Factors ◽  
Inflammatory Stimuli ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial

Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, but transcriptional mechanisms specifying their identities and functional states remain poorly understood. Here, we report a genome-wide assessment of regulatory landscapes of primary human aortic endothelial cells (HAECs) under basal and activated conditions, enabling inference of transcription factor networks that direct homeostatic and pro-inflammatory programs. We demonstrate that 43% of detected enhancers are EC-specific and contain SNPs associated to cardiovascular disease and hypertension. We provide evidence that AP1, ETS, and GATA transcription factors play key roles in HAEC transcription by co-binding enhancers associated with EC-specific genes. We further demonstrate that exposure of HAECs to oxidized phospholipids or pro-inflammatory cytokines results in signal-specific alterations in enhancer landscapes and associate with coordinated binding of CEBPD, IRF1, and NFκB. Collectively, these findings identify cis-regulatory elements and corresponding trans-acting factors that contribute to EC identity and their specific responses to pro-inflammatory stimuli.

Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells

2009 ◽  
Vol 44 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Noriko Miyazawa ◽  
Michiaki Abe ◽  
Tomokazu Souma ◽  
Masayuki Tanemoto ◽  
Takaaki Abe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Aortic Endothelial Cells ◽  
Human Aortic Endothelial Cells ◽  
Intracellular Oxidative Stress ◽  
Aortic Endothelial

Chemical Analysis of C-Reactive Protein Synthesized by Human Aortic Endothelial Cells Under Oxidative Stress

2012 ◽  
Vol 84 (21) ◽  
pp. 9646-9654 ◽  
Author(s):  
Ming-Hua Tsai ◽  
Chia-Liang Chang ◽  
Yu-San Yu ◽  
Ting-Yu Lin ◽  
Chin-Pong Chong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Chemical Analysis ◽  
C Reactive Protein ◽  
Aortic Endothelial Cells ◽  
Reactive Protein ◽  
Human Aortic Endothelial Cells ◽  
Aortic Endothelial
Sign in / Sign up

Export Citation Format

Share Document