scholarly journals Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one‐carbon metabolism

2020 ◽  
Vol 8 (18) ◽  
Author(s):  
Nicha P. Boonpattrawong ◽  
Saeid Golbidi ◽  
Daven C. Tai ◽  
Rika E. Aleliunas ◽  
Pascal Bernatchez ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Adult Male ◽  
Carbon Metabolism ◽  
Vascular Function ◽  
Maternal Obesity ◽  
Male Offspring ◽  
One Carbon Metabolism ◽  
Exercise During Pregnancy

scholarly journals Antenatal Hypoxia Affects Pulmonary Artery Contractile Functions via Downregulating L‐type Ca 2+ Channels Subunit Alpha1 C in Adult Male Offspring

2021 ◽  
Author(s):  
Huan Li ◽  
Bingyu Ji ◽  
Ting Xu ◽  
Meng Zhao ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Pulmonary Artery ◽  
Adult Male ◽  
Vascular Function ◽  
Pulmonary Arteries ◽  
Adverse Outcomes ◽  
Male Offspring ◽  
Epigenetic Mechanism ◽  
Vascular Health ◽  
Antenatal Hypoxia

Background Antenatal intrauterine fetal hypoxia is a common pregnancy complication that has profound adverse effects on an individual's vascular health later in life. Pulmonary arteries are sensitive to hypoxia, but adverse effects of antenatal hypoxia on pulmonary vasoreactivities in the offspring remain unknown. This study aimed to determine the effects and related mechanisms of antenatal hypoxia on pulmonary artery functions in adult male offspring. Methods and Results Pregnant Sprague‐Dawley rats were housed in a normoxic or hypoxic (10.5% O 2 ) chamber from gestation days 10 to 20. Male offspring were euthanized at 16 weeks old (adult offspring). Pulmonary arteries were collected for vascular function, electrophysiology, target gene expression, and promoter methylation studies. In pulmonary artery rings, contractions to serotonin hydrochloride, angiotensin II, or phenylephrine were reduced in the antenatal hypoxic offspring, which resulted from inactivated L‐type Ca 2+ channels. In pulmonary artery smooth muscle cells, the basal whole‐cell Ca 2+ currents, as well as vasoconstrictor‐induced Ca 2+ transients were significantly reduced in antenatal hypoxic offspring. In addition, increased promoter methylations within L‐type Ca 2+ channel subunit alpha1 C were compatible with its reduced expressions. Conclusions This study indicated that antenatal hypoxia programmed long‐lasting vascular hypocontractility in the male offspring that is linked to decreases of L‐type Ca 2+ channel subunit alpha1 C in the pulmonary arteries. Antenatal hypoxia resulted in pulmonary artery adverse outcomes in postnatal offspring, was strongly associated with reprogrammed L‐type Ca 2+ channel subunit alpha1 C expression via a DNA methylation‐mediated epigenetic mechanism, advancing understanding toward the effect of antenatal hypoxia in early life on long‐term vascular health.

scholarly journals Maternal obesity in the ewe increases cardiac ventricular expression of glucocorticoid receptors, proinflammatory cytokines and fibrosis in adult male offspring

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0189977 ◽  
Author(s):  
Adel B. Ghnenis ◽  
John F. Odhiambo ◽  
Richard J. McCormick ◽  
Peter W. Nathanielsz ◽  
Stephen P. Ford
Keyword(s):  
Proinflammatory Cytokines ◽  
Adult Male ◽  
Glucocorticoid Receptors ◽  
Maternal Obesity ◽  
Male Offspring

scholarly journals Maternal Obesity in Sheep Increases Fatty Acid Synthesis, Upregulates Nutrient Transporters, and Increases Adiposity in Adult Male Offspring after a Feeding Challenge

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122152 ◽  
Author(s):  
Nathan M. Long ◽  
Daniel C. Rule ◽  
Nuermaimaiti Tuersunjiang ◽  
Peter W. Nathanielsz ◽  
Stephen P. Ford
Keyword(s):  
Fatty Acid ◽  
Adult Male ◽  
Fatty Acid Synthesis ◽  
Maternal Obesity ◽  
Acid Synthesis ◽  
Male Offspring ◽  
Nutrient Transporters

Liver metabolism in adult male mice offspring: consequences of a maternal, paternal or both maternal and paternal high-fructose diet

2018 ◽  
Vol 9 (4) ◽  
pp. 450-459 ◽  
Author(s):  
P. V. Carapeto ◽  
F. Ornellas ◽  
C. A. Mandarim-de-Lacerda ◽  
M. B. Aguila
Keyword(s):  
Adverse Effects ◽  
Adult Male ◽  
Liver Metabolism ◽  
High Plasma ◽  
Male Offspring ◽  
High Fructose Diet ◽  
High Fructose ◽  
Tnf Α ◽  
Plasma Leptin ◽  
Hepatic Triacylglycerol

AbstractThe study aimed to evaluate the consequences of the consumption of a high-fructose diet (HFR; fructose was responsible for 45% of the energy from carbohydrates) by the mother, the father, or both on C57BL/6 adult male offspring. Non-consanguineous parents received the diet (HFR or control, C) from 8 weeks before mating until weaning (n=10 fathers and n=10 mothers on each diet). After weaning, only the C diet was offered to offspring. The groups were formed by one male randomly taken from each litter. The offspring groups were identified according to the mother’s diet (the first letter), then the father’s diet (the second letter), that is, C/C, C/HFR, HFR/C, HFR/HFR (n=10 per group). The parents exhibited the following characteristics: compared with those of the C group, the HFR parents had higher blood pressure (BP), enlarged liver, increased hepatic triacylglycerol content, hypercholesterolemia, hypertriglyceridemia, high plasma leptin and low adiponectin. The offspring exhibited the following characteristics: compared with the C/C group, the HFR/HFR group had high BP. The C/HFR, HFR/C and HFR/HFR showed elevated uric acid and leptin levels and diminished adiponectin. The HFR/HFR group showed liver inflammation (increased NFκB, SOCS3, JNK, TNF-α, IL1-β and IL6 levels). Likewise, SREBP-1c and FAS were upregulated. In conclusion, the consumption of a HFR by the mother and/or father is associated with adverse effects on liver metabolism in adult male offspring. When both mother and father are fed a HFR, the adverse effects on the offspring are more severe.

1395-P: Maternal Exercise during Pregnancy Affects Offspring Adiposity through One Carbon Metabolism Cycle

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1395-P
Author(s):  
NICHA BOONPATTRAWONG ◽  
ARYA MEHRAN ◽  
ISMAIL LAHER ◽  
ANGELA M. DEVLIN
Keyword(s):  
Carbon Metabolism ◽  
Maternal Exercise ◽  
One Carbon Metabolism ◽  
Exercise During Pregnancy ◽  
Offspring Adiposity

scholarly journals Cardiometabolic Phenotypic Differences in Male Offspring Born to Obese Preeclamptic-Like BPH/5 Mice

2021 ◽  
Vol 9 ◽  
Author(s):  
Kalie F. Beckers ◽  
Viviane C. L. Gomes ◽  
Kassandra J. Raven Crissman ◽  
Daniella M. Adams ◽  
Chin-Chi Liu ◽  
...  
Keyword(s):  
Adult Male ◽  
Maternal Obesity ◽  
Gestational Hypertension ◽  
Female Offspring ◽  
Left Ventricular ◽  
Male Offspring ◽  
Hypertensive Disorder ◽  
Male And Female ◽  
Similar Body ◽  
The Impact

Preeclampsia (PE) is a hypertensive disorder of pregnancy occurring in approximately 10% of women worldwide. While it is life threatening to both the mother and baby, the only effective treatment is delivery of the placenta and fetus, which is often preterm. Maternal obesity is a risk factor for PE, and the effects of both on offspring are long standing with increased incidence of cardiometabolic disease in adulthood. Obese BPH/5 mice spontaneously exhibit excessive gestational weight gain and late-gestational hypertension, similar to women with PE, along with fetal growth restriction and accelerated compensatory growth in female offspring. We hypothesized that BPH/5 male offspring will demonstrate cardiovascular and metabolic phenotypes similar to BPH/5 females. As previously described, BPH/5 females born to ad libitum-fed dams are overweight with hyperphagia and increased subcutaneous, peri-renal, and peri-gonadal white adipose tissue (WAT) and cardiomegaly compared to age-matched adult female controls. In this study, BPH/5 adult male mice have similar body weights and food intake compared to age-matched control mice but have increased inflammatory subcutaneous and peri-renal WAT and signs of cardiovascular disease: left ventricular hypertrophy and hypertension. Therefore, adult male BPH/5 do not completely phenocopy the cardiometabolic profile of female BPH/5 mice. Future investigations are necessary to understand the differences observed in BPH/5 male and female mice as they age. In conclusion, the impact of fetal programming due to PE has a transgenerational effect on both male and female offspring in the BPH/5 mouse model. The maternal obesogenic environment may play a role in PE pregnancy outcomes, including offspring health as they age.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

scholarly journals Effect of a Tailored Dietary Intervention with High or Standard Protein Intake on B-Vitamin and One Carbon Metabolism Status in Healthy Older Males: A 10 Week Randomised Controlled Trial

Proceedings ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 19
Author(s):  
Nicola Gillies ◽  
Amber M. Milan ◽  
Pankaja Sharma ◽  
Brenan Durainayagam ◽  
Sarah M. Mitchell ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Carbon Metabolism ◽  
Protein Intake ◽  
Dietary Intervention ◽  
Controlled Trial ◽  
One Carbon Metabolism ◽  
Randomised Controlled ◽  
B Vitamin ◽  
Standard Protein ◽  
Older Males

Background: Maintaining optimal status of folate and metabolically [...]

One carbon (metabolism) to rule T cell identity

2021 ◽  
Vol 21 (4) ◽  
pp. 206-206
Author(s):  
Felix Clemens Richter ◽  
Alexander J. Clarke
Keyword(s):  
T Cell ◽  
Carbon Metabolism ◽  
Cell Identity ◽  
One Carbon Metabolism
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