scholarly journals An intact animal model for the assessment of coronary blood flow regulation “Coronary blood flow regulation”

2020 ◽  
Vol 8 (14) ◽  
Author(s):  
Céline Boudart ◽  
Fuhong Su ◽  
Antoine Herpain ◽  
Jacques Creteur ◽  
Robert Naeije ◽  
...  
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Intact Animal ◽  
Flow Regulation ◽  
Blood Flow Regulation

scholarly journals Early Hyperdynamic Sepsis Alters Coronary Blood Flow Regulation in Porcine Fecal Peritonitis

2021 ◽  
Vol 12 ◽  
Author(s):  
Céline Boudart ◽  
Fuhong Su ◽  
Lorenzo Pitisci ◽  
Arnaud Dhoine ◽  
Olivier Duranteau ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Ex Vivo ◽  
Flow Regulation ◽  
Flow Reserve ◽  
Vasodilatory Response ◽  
Blood Flow Regulation ◽  
Microvascular Resistance ◽  
Hyperdynamic Sepsis

Background: Sepsis is a common condition known to impair blood flow regulation and microcirculation, which can ultimately lead to organ dysfunction but such contribution of the coronary circulation remains to be clarified. We investigated coronary blood flow regulatory mechanisms, including autoregulation, metabolic regulation, and endothelial vasodilatory response, in an experimental porcine model of early hyperdynamic sepsis.Methods: Fourteen pigs were randomized to sham (n = 7) or fecal peritonitis-induced sepsis (n = 7) procedures. At baseline, 6 and 12 h after peritonitis induction, the animals underwent general and coronary hemodynamic evaluation, including determination of autoregulatory breakpoint pressure and adenosine-induced maximal coronary vasodilation for coronary flow reserve and hyperemic microvascular resistance calculation. Endothelial-derived vasodilatory response was assessed both in vivo and ex vivo using bradykinin. Coronary arteries were sampled for pathobiological evaluation.Results: Sepsis resulted in a right shift of the autoregulatory breakpoint pressure, decreased coronary blood flow reserve and increased hyperemic microvascular resistance from the 6th h after peritonitis induction. In vivo and ex vivo endothelial vasomotor function was preserved. Sepsis increased coronary arteries expressions of nitric oxide synthases, prostaglandin I2 receptor, and prostaglandin F2α receptor.Conclusion: Autoregulation and metabolic blood flow regulation were both impaired in the coronary circulation during experimental hyperdynamic sepsis, although endothelial vasodilatory response was preserved.

scholarly journals Role of adenosine in coronary blood flow regulation after reductions in perfusion pressure.

1985 ◽  
Vol 56 (4) ◽  
pp. 517-524 ◽  
Author(s):  
W P Dole ◽  
N Yamada ◽  
V S Bishop ◽  
R A Olsson
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Perfusion Pressure ◽  
Flow Regulation ◽  
Blood Flow Regulation

Impairment of Coronary Blood Flow Regulation by Endothelium-Derived Nitric Oxide in Dogs with Alloxan-Induced Diabetes

1996 ◽  
Vol 28 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Toshiro Matsunaga ◽  
Ken Okumura ◽  
Hiroshi Ishizaka ◽  
Ryusuke Tsunoda ◽  
Shinji Tayama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Flow Regulation ◽  
Blood Flow Regulation

Role of endothelium-derived relaxing factor on coronary blood flow regulation in the dog

1993 ◽  
Vol 238 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Raúl Domenech ◽  
Pilar Macho ◽  
Mario Penna ◽  
Hermann Schwarze ◽  
Juan P. Huidobro-Toro ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Flow Regulation ◽  
Relaxing Factor ◽  
Blood Flow Regulation ◽  
Endothelium Derived Relaxing Factor

scholarly journals Indomethacin and the prostaglandin hypothesis of coronary blood flow regulation

1974 ◽  
Vol 241 (2) ◽  
pp. 299-308 ◽  
Author(s):  
Skoda Afonso ◽  
George T. Bandow ◽  
George G. Rowe
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Flow Regulation ◽  
Blood Flow Regulation
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