scholarly journals Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma

2020 ◽  
Vol 8 (11) ◽  
Author(s):  
Graham M. Donovan ◽  
Kimberley C. W. Wang ◽  
Danial Shamsuddin ◽  
Tracy S. Mann ◽  
Peter J. Henry ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Layer ◽  
Functional Improvement ◽  
Smooth Muscle Layer

scholarly journals Asthma: Pharmacological degradation of the airway smooth muscle layer

2020 ◽  
Vol 126 ◽  
pp. 105818
Author(s):  
Kimberley C.W. Wang ◽  
Graham M. Donovan ◽  
Alan L. James ◽  
Peter B. Noble
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Layer ◽  
Smooth Muscle Layer

Airway fibrosis in rats induced by vanadium pentoxide

2000 ◽  
Vol 278 (1) ◽  
pp. L209-L216 ◽  
Author(s):  
James C. Bonner ◽  
Annette B. Rice ◽  
Cindy R. Moomaw ◽  
Daniel L. Morgan
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Vanadium Pentoxide ◽  
Airway Remodeling ◽  
Mucous Cell ◽  
Intratracheal Instillation ◽  
Muscle Layer ◽  
Airway Smooth Muscle Cell ◽  
Smooth Muscle Layer ◽  
Airway Fibrosis

Vanadium pentoxide (V2O5) is a cause of occupational asthma and bronchitis. We previously reported that intratracheal instillation of rats with V2O5causes fibrosis of the lung parenchyma (J. C. Bonner, P. M. Lindroos, A. B. Rice, C. R. Moomaw, and D. L. Morgan. Am. J. Physiol. Lung Cell. Mol. Physiol. 274: L72–L80, 1998). In this report, we show that intratracheal instillation of V2O5induces airway remodeling similar to that observed in individuals with asthma. These changes include airway smooth muscle cell thickening, mucous cell metaplasia, and airway fibrosis. The transient appearance of peribronchiolar myofibroblasts, which were desmin and vimentin positive, coincided with a twofold increase in the thickness of the airway smooth muscle layer at day 6after instillation and preceded the development of airway fibrosis by day 15. The number of nuclear profiles within the smooth muscle layer also increased twofold after V2O5instillation, suggesting that hyperplasia accounted for thickening of the smooth muscle layer. The majority of cells incorporating bromodeoxyuridine at day 3 were located in the connective tissue surrounding the airway smooth muscle wall that was positive for vimentin and desmin. These data suggest that myofibroblasts are the principal proliferating cell type that contributes to the progression of airway fibrosis after V2O5injury.

Extracellular matrix within the airway smooth muscle layer correlates with age but not in cases of asthma

2016 ◽  
Author(s):  
John Elliot ◽  
Natasha Sandosham ◽  
Robyn Jones ◽  
Su-Ann Drew ◽  
Karen McKay ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Layer ◽  
Smooth Muscle Layer

Testosterone exposure in prenatal life disrupts epithelial nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh expression in prostate

Life Sciences ◽  
2021 ◽  
Vol 271 ◽  
pp. 119198
Author(s):  
Luana Araújo Manso ◽  
Barbara Costa Malmann Medeiros ◽  
Giovanna Amaral Rodrigues ◽  
Jordana Gomes Ramos ◽  
Mara Rúbia Marques ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Layer ◽  
Nuclear Morphology ◽  
Smooth Muscle Layer
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