scholarly journals Lactation induces increased IPSC bursting in oxytocinergic neurons

2019 ◽  
Vol 7 (8) ◽  
pp. e14047 ◽  
Author(s):  
Ion R. Popescu ◽  
Zafir Buraei ◽  
Juhee Haam ◽  
Feng‐Ju Weng ◽  
Jeffrey G. Tasker
Keyword(s):  
Oxytocinergic Neurons

Effects of central oxytocin receptor blockade on water and saline intake, mean arterial pressure, and c-Fos expression in rats

2003 ◽  
Vol 285 (6) ◽  
pp. R1331-R1339 ◽  
Author(s):  
Douglas A. Fitts ◽  
Simon N. Thornton ◽  
Alexandra A. Ruhf ◽  
Dannielle K. Zierath ◽  
Alan Kim Johnson ◽  
...  
Keyword(s):  
Pressor Response ◽  
Inhibitory Effect ◽  
Salt Appetite ◽  
Ang Ii ◽  
Preoptic Nucleus ◽  
Organum Vasculosum Laminae Terminalis ◽  
Fos Expression ◽  
Oxytocinergic Neurons ◽  
Oxytocin Antagonist ◽  
First Time

Central injection of ANG II has been proposed to have dual effects on salt appetite including a direct stimulatory effect and an indirect inhibitory effect through an activation of central oxytocinergic neurons. The inhibition was demonstrated by pretreating rats with central ornithine vasotocin (OVT; oxytocin antagonist) 30 min before a central ANG II injection. The OVT pretreatment produced a large increase in ANG II-induced saline intake. The present paper reports a failure to replicate that influential experiment. However, we also report for the first time that OVT by itself: 1) provokes drinking of both water and saline solution with a latency almost as short as that produced by ANG II; 2) produces a mild pressor response; and 3) increases c-Fos expression in the organum vasculosum laminae terminalis (OVLT) and the median preoptic nucleus (MnPO). Oxytocin activity may provide an inhibitory control of drinking responses as has been suggested, but the inhibition is tonic and includes both water and saline drinking. Inhibition of this tonic activity may stimulate drinking by increasing neural activity in the OVLT and MnPO.

scholarly journals Peripheral chemoreceptors mediate training-induced plasticity in paraventricular nucleus pre-autonomic oxytocinergic neurons

2012 ◽  
Vol 98 (2) ◽  
pp. 386-396 ◽  
Author(s):  
Josiane C. Cruz ◽  
Marina T. Cavalleri ◽  
Alexandre Ceroni ◽  
Lisete C. Michelini
Keyword(s):  
Paraventricular Nucleus ◽  
Peripheral Chemoreceptors ◽  
Oxytocinergic Neurons

Characterization of social behaviors and oxytocinergic neurons in the S-100β overexpressing mouse model of Down Syndrome

2003 ◽  
Vol 141 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Alice Borella ◽  
Reka Sumangali ◽  
Jacqueline Ko ◽  
Patricia M. Whitaker-Azmitia
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Social Behaviors ◽  
Oxytocinergic Neurons

The effect of adrenalectomy on Fos expression in vasopressinergic and oxytocinergic neurons in response to stress in the rat

Stress ◽  
2007 ◽  
Vol 10 (4) ◽  
pp. 332-341 ◽  
Author(s):  
M. T. C. Laguna-Abreu ◽  
L. Margatho ◽  
C. M. R. Germano ◽  
J. Antunes-Rodrigues ◽  
L. L. K. Elias ◽  
...  
Keyword(s):  
Response To Stress ◽  
Fos Expression ◽  
Oxytocinergic Neurons

scholarly journals Oxytocin regulation of social transmission of fear in zebrafish reveals its evolutionary conserved role in emotional contagion

2021 ◽  
Author(s):  
Ibukun Akinrinade ◽  
Kyriacos Kareklas ◽  
Michael Gliksberg ◽  
Giovanni Petri ◽  
Gil Levkowitz ◽  
...  
Keyword(s):  
Emotional Contagion ◽  
Brain Regions ◽  
Lateral Septum ◽  
Social Transmission ◽  
Proximate Mechanisms ◽  
Action Mechanisms ◽  
Social Fear ◽  
Complex Forms ◽  
Oxytocinergic Neurons

Emotional contagion is the most ancestral form of empathy that relies on simple perception-action mechanisms, on top of which more complex forms of empathic behaviors, such as consolation and helping, have evolved. Here we tested to what extent the proximate mechanisms of emotional contagion are evolutionary conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish, which represents an evolutionary divergent line to that of tetrapods, within vertebrates. Using mutants for the ligand of the fish oxytocin nonapeptide and both of its receptors in zebrafish we showed that oxytocin is necessary for observer zebrafish to copy the distressed behavior of conspecific demonstrators. Exogeneous administration of oxytocin to the ligand mutant rescued the ability of observers to express social fear transmission, indicating that oxytocin is not only necessary but also sufficient for emotional contagion. The brain regions in the ventral telencephalon that are associated with emotional contagion in zebrafish are homologous to those known to be involved in the same process in rodents (e.g. striatum, lateral septum), and receive direct projections from oxytocinergic neurons located in the preoptic area. Finally, we ruled out the hypothesis that social transmission of fear in zebrafish merely relies on behavior contagion by motor imitation, and we showed that it rather relies on emotion discrimination. Together our results support an evolutionary conserved role for oxytocin as a key regulator of basic empathic behaviors across vertebrates.

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